Fabrication of photonic force devices for biomolecule dynamics

Abstract

We microfabricated the plasmonic nanopore with ~ 1 nm on top of the pyramid for single molecule dynamics. This plasmonic micro device provides huge photon transmission through the fabricated nanochannel on the top of the pyramidal structure. This can generate the huge photonic pressure gradient between the free space and nanopore inside.. The huge pressure gradient can be attributed to the resonance transmission between the fabricated V groove cavity and the nanosize waveguide formed during the metal deposition. This fabricated huge photonic device can be utilized as biomolecule translocation and single molecule dynamics.

DNA translocation through a periodically patterned nanoprobe

“…The plasmonic metallic nano-pore can be utilized as a single molecule bio-sensor due to the huge increase of the surface enhanced Raman signal intensity [16][17][18][19][20]. The plasmonic nanochannel on the pyramidal probe can be utilized for biomolecule sensor due to "plasmonic hot spot" formed at the Au nanometer aperture [18,19]. The microfabricated V-groove cavity type reactor can be utilized for individual bioreactor.…”

“…The photonic force required to manipulate the biological molecules such as DNA and micron size cells should be ~ 200 pico-newtons [12][13][14][15]. The plasmonic metallic nano-pore can be utilized as a single molecule bio-sensor due to the huge increase of the surface enhanced Raman signal intensity [16][17][18][19][20]. The plasmonic nanochannel on the pyramidal probe can be utilized for biomolecule sensor due to "plasmonic hot spot" formed at the Au nanometer aperture [18,19].…”