Fabrication of PLA/PEG/MWCNT electrospun nanofibrous scaffolds for anticancer drug delivery

Abstract

In the present study, polylactic acid (PLA)/polyethylene glycol (PEG)/multiwalled carbon nanotube (MWCNT) electrospun nanofibrous scaffolds were prepared via electrospinning process and their applications for the anticancer drug delivery system were investigated. A response surface methodology based on Box–Behnken design (BBD) was used to evaluate the effect of key parameters of electrospinning process including solution concentration, feeding rate, tip–collector distance (TCD) and applied voltage on the morphology of PLA/PEG/MWCNT nanofibrous scaffolds. In optimum conditions (concentration of 8.15%, feeding rate of 0.2 mL/h, voltage of 18.50 kV and TCD of 13.0 cm), the minimum experimental fiber diameter was found to be 225 nm which was in good agreement with the predicted value by the BBD analysis (228 nm). In vitro drug release study of doxorubicin (DOX)‐loaded nanofibrous scaffolds, higher drug content induced an extended release of drug. Also, drug release rate was not dependent on drug/polymer ratio in different electrospun nanofibrous formulations. The equation of Mt = c0 + kt0.5was used to describe the kinetic data of DOX release from electrospun nanofibers. The cell viability of DOX‐loaded nanofibrous scaffolds was evaluated using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide, a tetrazole assay on lung cancer A549 cell lines. We propose that DOX‐incorporated PLA/PEG/MWCNT nanofibrous scaffold could be used as a superior candidate for antitumor drug delivery. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41286.

3D Composite Assemblies of Microparticles and Nanofibers for Tailored Wettability and Controlled Drug Delivery

“…The important effect of the thickness of the PLA membrane on the release kinetics was shown. Furthermore, it was also shown that adding a water soluble polymer such as poly(ethylene glycol) (PEG) in the PLA matrix of the nanofibers enhanced the release of drug . In the same way, Xu et al showed that an increase of the hydrophilicity of nanofibrous membrane using a surfactant led to an increased drug release rate.…”

Physical, morphological, and biological studies on PLA/nHA composite nanofibrous webs containing Equisetum arvense herbal extract for bone tissue engineering

“…Biodegradable polyesters such as poly(lactic‐ co ‐glycolic acid), poly(ɛ‐caprolactone) (PCL), poly(lactic acid) (PLA), and poly(glycolic acid), are considered as most common synthetic polyesters used in bone tissue engineering and drug delivery . Among them, PLA has been widely utilized in bone regeneration applications because of its semicrystalline nature, good strength, low toxicity, and predictable biodegradation rate.…”

对氨基苯甲酸掺杂的微槽结构碳纤维用于改善pla-Peg的强度及生物相容性

“…High porosity always results in poor compressive performances inevitably, while PABA-CFs reinforcement here can dominate the loss by their robust integration with polymer matrix. Generally, compressive strength for non-stress bone sites is required to be higher than 4 MPa [43]. The biocomposites containing 0.5 and 2 wt.% PABA-CFs can stand 4.36 and 5.48 MPa compressive strength, respectively (P < 0.05), which satisfies the basic mechanical requirements for non-stress bone tissue.…”