Fabrication of PMMA nanofluidic electrochemical chips with integrated microelectrodes

Liu, Junshan; Wang, Liang; Ouyang, Wei; Wang, Wei; Qin, Jun; Xu, Zheng; Xu, Shuai; Wang, Longchang; Liu, Chong; Wang, Liding

doi:10.1016/j.bios.2015.05.031

Cited by 15 publications

(8 citation statements)

References 36 publications

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“…The detailed fabrication processes are described in our previous work. 13 The substrate plate also was formed by injection molding. Finally, both plates were aligned by two through-holes and glued together using an adhesive layer to complete the microfluidic device, as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Investigation of injection molding of orthogonal fluidic connector for microfluidic devices

Cao

Zhao

et al. 2017

AIP Advances

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Orthogonal fluidic connections are essential for developing multilayered microfluidic devices. At present, most orthogonal connectors are realized by a horizontal channel and a vertical channel in different plates. Therefore, some extra alignment and adhesion processes for precise plate assembly are required. In this paper, the method of injection molding is proposed to make a one-body-type orthogonal connector in a single plastic plate. The connector was composed of a cantilevered tube and the other in the substrate. An injection mold was developed in which a side core-pulling mechanism and an ejection mechanism of push-pipes were combined to form the mold for an orthogonal connector. Both the type and the location of gate were optimized for the mold. The results showed that the fan gate in the middle position of the plate was the most suitable in term of both defect control and practicability. The effect of melt temperature was numerically investigated and then verified experimentally. With the optimized parameters, the relative length and the relative wall thickness of a cantilevered tube in the plastic part can reach 98.89% and 99.80%, respectively. Furthermore, using the plastic part as a cover plate, a three-layer plastic microfluidic device was conveniently fabricated for electrochemical detection.

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Section: Resultsmentioning

confidence: 99%

Investigation of injection molding of orthogonal fluidic connector for microfluidic devices

Cao

Zhao

et al. 2017

AIP Advances

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“…Thermoplastic nanofluidic devices have also been used for the electrochemical detection of small molecules, 138 investigation of enzyme reaction kinetics 139 and identification of single nucleotide polymorphisms (SNP). 140 …”

Section: Applications Of Thermoplastic Nanochannelsmentioning

confidence: 99%

“…Liu et al 138 developed a protocol for the integration of microelectrodes onto a PMMA nanofluidic device for the electrochemical detection of biotin at concentrations as low as 1 aM. This device was combined with nanoparticle crystals and the use of a PMMA substrate that showed better signal-to-noise and a higher sensitivity with easy fabrication compared to a glass-based device.…”

Section: Applications Of Thermoplastic Nanochannelsmentioning

confidence: 99%

Thermoplastic nanofluidic devices for biomedical applications

et al. 2017

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Microfluidics is now moving into a developmental stage where basic discoveries are being transitioned into the commerical sector so that these discoveries can affect, for example, healthcare. Thus, high production rate microfabrication technologies, such as thermal embossing and/or injection molding, are being used to produce low-cost consumables appropriate for commercial applications. Based on recent reports, it is clear that nanofluidics offers some attractive process capabilities that may provide unique venues for biomolecular analyses that cannot be realized at the microscale. Thus, it would be attractive to consider early in the developmental cycle of nanofluidics production pipelines that can generate devices possessing sub-150 nm dimensions in a high production mode and at low-cost to accommodate the commercialization of this exciting technology. Recently, functional sub-150 nm thermoplastic nanofluidic devices have been reported that can provide high process yield rates, which can enable commericial translation of nanofluidics. This review presents an overview of recent advancements in the fabrication, assembly, surface modification and the characterization of thermoplastic nanofluidic devices. Also, several examples in which nanoscale phenomena have been exploited for the analysis of biomolecules are highlighted. Lastly, some general conclusions and future outlooks are presented.

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“…The polymer polymethyl methacrylate (PMMA) was selected for this work, because it is an attractive and widely used polymer in the fabrication of optical and electronic devices, and lithographic techniques . Moreover, thin films of PMMA can be easily formed by spin coating, can be integrated into various components easily . In all the lithography techniques PMMA layer is intentionally patterned to fabricate various structural components.…”

Section: Introductionmentioning

confidence: 97%

Electric Field Induced Pattern Formation on PMMA and ITO Layers

Kathalingam

2018

Physica Status Solidi (a)

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This letter reports on electric field induced pattern formation on a spin‐coated PMMA layer. The PMMA layer is coated onto p‐type silicon substrate using a spin coater at 3000 rpm. A perpendicular electric field is produced by applying a potential difference between the PMMA film and a parallel plate ITO conductor with water trapped between them. Different patterns are formed on PMMA and ITO layers depending upon the strength of electric field and time duration. The formed patterns are studied by scanning electron microscopy and atomic force microscopy. Mechanism of pattern formation and examination of formed pattern are discussed in this report.

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Fabrication of PMMA nanofluidic electrochemical chips with integrated microelectrodes

Cited by 15 publications

References 36 publications

Investigation of injection molding of orthogonal fluidic connector for microfluidic devices

Investigation of injection molding of orthogonal fluidic connector for microfluidic devices

Thermoplastic nanofluidic devices for biomedical applications

Electric Field Induced Pattern Formation on PMMA and ITO Layers

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