Fabrication of poly(d,l-lactide-co-glycolide) nanoparticles using a simple fluidic device with a tapered glass capillary and the effect of thermodynamic parameters

Kim, Joo Hwan; Ryu, Tae Kyung; Jeong, Ki Young; Paik, Dong-Hyun; Moon, Seung-Kwan; Choi, Sung‐Wook

doi:10.1007/s40005-014-0162-z

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…In the present experiment, PVA was used as a matrix owing to its good processability to form free-standing film, originating from its outstanding dispersibility in aqueous solution, flexibility, adhesion and oxygen barrier property. [31][32][33][34][35][36][37][38][39][40][41][42][43] As a result, PVA dispersed in solution was well infiltrated into the 3D hollow graphene structure via a dip-coating process, and free-standing graphene/PVA films of ca. 4.3 µm thickness were fabricated after drying at 70 °C.…”

Section: Resultsmentioning

confidence: 99%

Flexible free-standing composite films having 3D continuous structures of hollow graphene ellipsoids

et al. 2015

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Graphene composites have great potential in electrical and electronic applications due to their outstanding physicochemical, electrical, and mechanical properties. Unfortunately, current graphene preparation technologies allow the exploitation of only an exceptionally low percentage of graphene's capability. Herein, free-standing graphene films based on three-dimensional (3D) continuous structures of hollow graphene ellipsoids were successfully fabricated, whose composite structure has never been investigated. Positively charged polystyrene (PS) spheres were first wrapped with negatively charged graphene upon simple mixing, and became ellipsoids by stretching. Due to their improved continuity, composites based on the ellipsoids and spherical microparticles have lower sheet resistances than those based on spherical nanoparticles. Upon folding and application of pressure, composites based on the hollow graphene ellipsoids exhibited superior electrical conductivity and structural stability owing to their high mechanical strength and effective electron transport pathway. The ability to control the face-contact structures of graphene in a polymer matrix by means of particle morphology represents an effective strategy for future composite engineering.

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Section: Resultsmentioning

confidence: 99%

Flexible free-standing composite films having 3D continuous structures of hollow graphene ellipsoids

et al. 2015

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Finding key nanoprecipitation variables for achieving uniform polymeric nanoparticles using neurofuzzy logic technology

Jara

Catalán-Figueroa

Landín

et al. 2017

Drug Deliv. and Transl. Res.

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Nanoprecipitation is a simple and fast method to produce polymeric nanoparticles (Np); however, most applications require filtration or another separation technique to isolate the nanosuspension from aggregates or polydisperse particle production. In order to avoid variability introduced by these additional steps, we report here a systematic study of the process to yield monomodal and uniform Np production with the nanoprecipitation method. To further identify key variables and their interactions, we used artificial neural networks (ANN) to investigate the multiple variables which influence the process. In this work, a polymethacrylate derivative was used for Np (NpERS) and a database with several formulations and conditions was developed for the ANN model. The resulting ANN model had a high predictability (> 70%) for NpERS characteristics measured (mean size, PDI, zeta potential, and number of particle populations). Moreover, the model identified production variables leading to polymer supersaturation, such as mixing time and turbulence, as key in achieving monomodal and uniform NpERS in one production step. Polymer concentration and type of solvent, modifiers of polymer diffusion and supersaturation, were also shown to control NpERS characteristics. The ANN study allowed the identification of key variables and their interactions and resulted in a predictive model to study the NpERS production by nanoprecipitation. In turn, we have achieved an optimized method to yield uniform NpERS which could pave way for polymeric nanoparticle production methods with potential in biological and drug delivery applications.

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Structural implications of polyphenolic antioxidants

Halake

Birajdar

Lee

2016

Journal of Industrial and Engineering Chemistry

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Fabrication of poly(d,l-lactide-co-glycolide) nanoparticles using a simple fluidic device with a tapered glass capillary and the effect of thermodynamic parameters

Cited by 3 publications

References 20 publications

Flexible free-standing composite films having 3D continuous structures of hollow graphene ellipsoids

Flexible free-standing composite films having 3D continuous structures of hollow graphene ellipsoids

Finding key nanoprecipitation variables for achieving uniform polymeric nanoparticles using neurofuzzy logic technology

Structural implications of polyphenolic antioxidants

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