Fabrication of polymer brush surfaces with highly-ordered perfluoroalkyl side groups at the brush end and their antibiofouling properties

Wang, Lin; Chen, Xiang; Cao, Xinyu; Xu, Jianquan; Zuo, Biao; Zhang, Li; Wang, Xinping; Yang, Juping; Yao, Yanqing

doi:10.1039/c5tb00210a

Cited by 16 publications

(18 citation statements)

References 85 publications

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“…Except for the spin or dip-coating methods to prepare phase-separated surfaces, “grafting from” is becoming one of the versatile surface modification methods, , by which polymer brushes were covalently linked to substrate. Poly(ethylene glycol) (PEG) poly( N -isopropylacrylamide) (PNIPAM), and poly(methyl methacrylate (PMMA) and fluorine-containing polymers are widely adopted to regulate the interaction of proteins or cells with surfaces. , In previous work, we prepared random amphiphilic copolymer brushes of PAM- ran -PFMA and PHEAA-C 3 F 7 grafting from Si surface, respectively. The antiprotein adsorption and bacteria adhesion performance of amphiphilic surface prepared were further investigated.…”

Section: Introductionmentioning

confidence: 99%

“…Poly(ethylene glycol) (PEG) 46 poly(N-isopropylacrylamide) (PNIPAM), 47 and poly(methyl methacrylate (PMMA) 48 and fluorine-containing polymers are widely adopted to regulate the interaction of proteins or cells with surfaces. 49,50 In previous work, we prepared random amphiphilic copolymer brushes of PAM-ran-PFMA 8 and PHEAA-C 3 F 7 24 grafting from Si surface, respectively. The antiprotein adsorption and bacteria adhesion performance of amphiphilic surface prepared were further investigated.…”

Section: ■ Introductionmentioning

confidence: 99%

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Diblock Polymer Brush (PHEAA-b-PFMA): Microphase Separation Behavior and Anti-Protein Adsorption Performance

Zhang

Huang

et al. 2018

Langmuir

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In this paper, a series of amphiphilic diblock polymers of poly(hydroxyethylacrylamide)- b-poly(1H,1H-pentafluoropropyl methacrylate) (PHEAA- b-PFMA) were grafted from silicon wafer via surface-initiated atom transfer radical polymerization (SI-ATRP). Surface wettability and chemical compositions of the modified surfaces were characterized by contact angle goniometer and X-ray photoelectron spectroscopy (XPS) respectively. Molecular weight and polydispersity of each block were measured using gel permeation chromatography (GPC). The topography and the microphase separation behavior of PHEAA- b-PFMA surfaces were investigated by atomic force microscope (AFM). The results show that only when the grafting density (σ) and thickness of PHEAA brush were in the range of 0.9-1.3 (chain/nm) and 6.6-15.1 nm, respectively, and the ratio of PFMA/PHEAA varied from 89/42 to 89/94, could the diblock copolymer phase separate into nanostructures. Further, the antiprotein adsorption performance of the modified surfaces against BSA, fibrinogen, and lysozyme was studied. The results indicated the modified surfaces could reduce the protein adsorption compared to the pristine silicon wafer. For Fibrinogen, the antiadsorption effect of PHEAA- b-PFMA-modified surfaces with microphase segregation was better than that of corresponding PHEAA modified surfaces. The results provide further evidence that surface composition and microphase segregation of fluorinated moieties of block copolymer brushes significantly impact protein adsorption behaviors.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Diblock Polymer Brush (PHEAA-b-PFMA): Microphase Separation Behavior and Anti-Protein Adsorption Performance

Zhang

Huang

et al. 2018

Langmuir

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“…This indicates that the increased surface hydrophobicity produced by the PDMS was responsible for the improved antifouling action of these copolymers ( Santiago et al, 2016 ). Xinping Wang et al described the preparation of acrylate block polymer brushes with two 2-perfluorooctylethyl methacrylate units at the brush end on an Au substrate with a “grafting to” method ( Wang et al, 2015 ). It was found that the amount of fibrinogen adsorbed to the surface was reduced in proportion to the hydrophobicity of the perfluoroalkyl chains ( Wang et al, 2015 ).…”

Section: Anti-biofouling Polymers With Special Surface Wettabilitymentioning

confidence: 99%

“…Xinping Wang et al described the preparation of acrylate block polymer brushes with two 2-perfluorooctylethyl methacrylate units at the brush end on an Au substrate with a “grafting to” method ( Wang et al, 2015 ). It was found that the amount of fibrinogen adsorbed to the surface was reduced in proportion to the hydrophobicity of the perfluoroalkyl chains ( Wang et al, 2015 ).…”

Section: Anti-biofouling Polymers With Special Surface Wettabilitymentioning

confidence: 99%

Anti-Biofouling Polymers with Special Surface Wettability for Biomedical Applications

Yang

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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The use of anti-biofouling polymers has widespread potential for counteracting marine, medical, and industrial biofouling. The anti-biofouling action is usually related to the degree of surface wettability. This review is focusing on anti-biofouling polymers with special surface wettability, and it will provide a new perspective to promote the development of anti-biofouling polymers for biomedical applications. Firstly, current anti-biofouling strategies are discussed followed by a comprehensive review of anti-biofouling polymers with specific types of surface wettability, including superhydrophilicity, hydrophilicity, and hydrophobicity. We then summarize the applications of anti-biofouling polymers with specific surface wettability in typical biomedical fields both in vivo and in vitro, such as cardiology, ophthalmology, and nephrology. Finally, the challenges and directions of the development of anti-biofouling polymers with special surface wettability are discussed. It is helpful for future researchers to choose suitable anti-biofouling polymers with special surface wettability for specific biomedical applications.

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“…61 These results were consistent with the previous research that the highly closepacked array of perfluoroalkyl side groups improved protein resistance properties. 62 Thus, surface fluorination with F15 was an effective method to construct an antifouling surface.…”

Section: Acs Applied Bio Materialsmentioning

confidence: 99%

Surface Fluorination Modification and Anti-Biofouling Study of a pHEMA Hydrogel

Yang

Cui

Zhou

et al. 2020

ACS Appl. Bio Mater.

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A poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel film was prepared by bulk polymerization. Then, it was surface modified by perfluorooctanoyl chloride to improve the anti-biofouling properties. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDXS), and atomic force microscopy (AFM) analyses demonstrated that the uniform dense fluorinated layer had been successfully grafted onto pHEMA. The water contact angle (WCA) of the modified pHEMA film increased to 135°, while the surface energy decreased to 13.32 mN/m. The protein and bacterial adhesion properties of the modified pHEMA were decreased significantly. The in vitro cytotoxicity showed that the modified pHEMA was noncytotoxic. Thus, the fluorinated modification on the material surface was a convenient and effective method to establish a hydrophobic and anti-biofouling surface.

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Fabrication of polymer brush surfaces with highly-ordered perfluoroalkyl side groups at the brush end and their antibiofouling properties

Abstract: The protein-resistant performance was enhanced greatly by constructing a polymer brush surface with perfectly close-packed perfluoroalkyl groups.

Cited by 16 publications

References 85 publications

Diblock Polymer Brush (PHEAA-b-PFMA): Microphase Separation Behavior and Anti-Protein Adsorption Performance

Diblock Polymer Brush (PHEAA-b-PFMA): Microphase Separation Behavior and Anti-Protein Adsorption Performance

Anti-Biofouling Polymers with Special Surface Wettability for Biomedical Applications

Surface Fluorination Modification and Anti-Biofouling Study of a pHEMA Hydrogel

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