Fabrication of Polymeric Biochips With µ-Fluidic Channel by Injection Molding Technology

Abstract

The polymeric biochip has been focused as a cheap, rapid and simplified method to replace the existing biochemical laboratory works. This biochip is formed miniaturized lab functionalities on a chip with the development of MEMS technology. This has many micro-fluidic channels for the flow of sample and reagents, mixing and detection task. Existing technologies for the biochip fabrication are utilizing various micro pattern forming methods, such as etching, LIGA, and micro-imprinting etc. In this study, an injection molding process with micro mold was applied to the mass production of polymeric biochip which contains micro-fluidic channel. Micro cutting process was applied to fabricate the core feature for molding micro-fluidic channel. Therefore, a series of micro cutting experiments using micro endmill were performed to determine optimum cutting conditions. Besides, the low temperature micro-cutting experiments using micro endmills were performed to improve the quality of micro mold core by reducing the burr and surface roughness. After the verification of low temperature micro-cutting process efficiency, this process was used to fabricate required mold core for micro feature. Finally, test injection molding process using manufactured micro mold and COC polymer were performed, and then the results were investigated.

Çip Üstü Laboratuvar Üretim Teknolojileri

“…Son ürün, montaj veya işleme için kalıptan çıkarılır. Bu yöntem, karmaşık mikroakışkan cihazları hızlı ve hatasıza yakın bir şekilde üretebildiği için büyük ölçekli üretime uygun bir yöntemdir [6].…”

Warpage Characterization of Microchannels Fabricated by Injection Molding

“…Injection molding can also transfer micrometer or even submicrometer features of molds to a product [4]. Injection molding has been utilized for the fabrication of various microscale devices and their components [4][5][6][7][8][9][10] as well as nanofluidic channels [11]. For a good product quality, the mold needs to be manufactured so as to yield the desired features with desired accuracy.…”