Fabrication of polyphenol-incorporated anti-inflammatory hydrogel via high-affinity enzymatic crosslinking for wet tissue adhesion

Kim, Su Hwan; Kim, Kyungmin; Kim, Beom Seok; An, Young‐Hyeon; Lee, Uk‐Jae; Lee, Sanghyuk; Kim, Seunghyun L.; Kim, Byung‐Gee; Hwang, Nathaniel S.

doi:10.1016/j.biomaterials.2020.119905

Cited by 121 publications

(66 citation statements)

References 43 publications

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“…The plumbagin caged silver nanoparticles composite was superior to the native collagen for the in vivo healing and more antibacterial than the plumbagin extract alone. A mixture of hyaluronic acid (HA) conjugated with EGCG and tyramine were explored as anti-inflammatory adhesive biomaterials for potential clinical application [ 145 ]. Rheological analysis, gel degradation, biocompatibility, and inflammation in vitro and in vivo were all investigated.…”

Section: Towards Therapeutic Application: Antioxidant Biomaterialsmentioning

confidence: 99%

“…Aloe vera [144] EGCG [145] Soybean (extract) [146] Tannic acid [129] Vitamin C [133] Gelatin-Hap [146] HA [129,145] P(3HB-co-3HV) [133] SF [144] Biomechanical stability…”

Section: Scavenging Activitymentioning

confidence: 99%

“…[193] Peppermint E.O. [193] Plumbagin [159] Rosmarinic acid [194] Soybean (oil) [167] Tannic acid [195] Tyramine [145] Vitamin E [196] Cellulose acetate [193] CH [184,194,196] CH-derivates [116] Collagen [159] Gelatin [186] HA [145] HPG [164,190] PA-6 [167] PCL [185] PCL-gum [163] PCL-gum [191,192] PEG-PCL [134] PLGA [154,182,183,187,188] Poly-tannic acid [195] PVA derivatives [189] Cell proliferation…”

Section: Hydrophilicity and Wettability/swellingmentioning

confidence: 99%

“…[217][218][219] Thymol [132,220,221] Vitamin E [222] Zataria Multiflora E.O. [169] ALG [211] Cellulose acetate [193,221] Cellulose acetate-gelatin [162] Cellulose-PEG [120] CH [112,210,220] CH-derivatives [215,218] CH-gelatin [219] Collagen [159] Gelatin derivates-collagen [158] Gelatin-gum [216] Hap [201] Ionomer cement [214] PCL [165] PCL-CH [149] PCL-gum [191,192] PDMS [125] PEG-ALG [109] PLA [127] PLA-CH [212,213] PLA-derivatives [152,222] PLA-PEG [130] PVA [174] PVA derivates [169] PVP [209] Silica-PEG [114] β-cyclodextrin [217] Immunomodulation and anti-inflammatory effect Aloe vera (extract) [223,224] Citric acid [135] Curcumin [154] EGCG …”

Section: Cell Differentiationmentioning

confidence: 99%

“…[224] HA [145] Hap [202] PLGA [154] PVA [135] SF [225,226] ALG, alginate; CH, chitosan; E.O., essential oil; HA, hyaluronic acid; Hap, hydroxyapatite; P(3HB-co-3HV), poly(3-hydroxybutyrate-co-3-hydroxyvalerate); PBAE, poly(β-amino ester); PCL polycaprolactone; PDMS, polydimethylsiloxane: PDX, polydioxanone; PE, polyethylene, PEG, polyethylene glycol; PHBV, poly(3-hydroxybutyrate-co-3-hydroxyvalerate); PLA, polylactic acid; PLGA, poly(lactic-co-glycolic acid); PU, polyuretane; PVA, polyvinyl alcohol; PVP, polyvinylpyrrolidone; SF, silk fibroin.…”

Section: Cell Differentiationmentioning

confidence: 99%

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Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Marrazzo

O’Leary

2020

Bioengineering

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Although a large panel of natural antioxidants demonstrate a protective effect in preventing cellular oxidative stress, their low bioavailability limits therapeutic activity at the targeted injury site. The importance to deliver drug or cells into oxidative microenvironments can be realized with the development of biocompatible redox-modulating materials. The incorporation of antioxidant compounds within implanted biomaterials should be able to retain the antioxidant activity, while also allowing graft survival and tissue recovery. This review summarizes the recent literature reporting the combined role of natural antioxidants with biomaterials. Our review highlights how such functionalization is a promising strategy in tissue engineering to improve the engraftment and promote tissue healing or regeneration.

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Section: Towards Therapeutic Application: Antioxidant Biomaterialsmentioning

confidence: 99%

“…Aloe vera [144] EGCG [145] Soybean (extract) [146] Tannic acid [129] Vitamin C [133] Gelatin-Hap [146] HA [129,145] P(3HB-co-3HV) [133] SF [144] Biomechanical stability…”

Section: Scavenging Activitymentioning

confidence: 99%

Section: Hydrophilicity and Wettability/swellingmentioning

confidence: 99%

Section: Cell Differentiationmentioning

confidence: 99%

Section: Cell Differentiationmentioning

confidence: 99%

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Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Marrazzo

O’Leary

2020

Bioengineering

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Biological Significance of Polyphenols as Functional Molecules in Biomaterial Preparations

Vinayagamurthy,

Kumar,

Yalavarthi

et al. 2024

Science and Engineering of Polyphenols

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Injectable Self‐Healing Natural Biopolymer‐Based Hydrogel Adhesive with Thermoresponsive Reversible Adhesion for Minimally Invasive Surgery

Lei

Dai

Fan

et al. 2021

Adv Funct Materials

203

192

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Biocompatible hydrogel adhesives with multifunctional properties, including injectability, fast self-healing, and suitable on-demand detachment, are highly desired for minimally invasive procedures, but such materials are still lacking. Herein, an injectable self-healing biocompatible hydrogel adhesive with thermoresponsive reversible adhesion based on two extracellular matrix-derived biopolymers, gelatin and chondroitin sulfate, is developed to be used as a surgical adhesive for sealing or reconnecting ruptured tissues. The resulting hydrogels present good self-healing and can be conveniently injected through needles. The strong tissue adhesion at physiological temperatures originates from the Schiff base and hydrogen bonding interactions between the hydrogel and tissue that can be weakened at low temperatures, thereby easily detaching the hydrogel from the tissue in the gelation state. In vivo and ex vivo rat model show that the adhesives can effectively seal bleeding wounds and fluid leakages in the absence of sutures or staples. Specifically, a proof of concept experiment in a damaged rat liver model demonstrates the ability of the adhesives to act as a suitable laparoscopic sealant for laparoscopic surgery. Overall, the adhesive has several advantages, including low cost and ease of production and application that make it an exceptional multifunctional tissue adhesive/sealant, effective in minimally invasive surgical applications.

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Fabrication of polyphenol-incorporated anti-inflammatory hydrogel via high-affinity enzymatic crosslinking for wet tissue adhesion

Cited by 121 publications

References 43 publications

Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Biological Significance of Polyphenols as Functional Molecules in Biomaterial Preparations

Injectable Self‐Healing Natural Biopolymer‐Based Hydrogel Adhesive with Thermoresponsive Reversible Adhesion for Minimally Invasive Surgery

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