Fabrication of polystyrene-encapsulated magnetic iron oxide nanoparticles via batch and microfluidic-assisted production

Taddei, Chiara; Sansone, Lucia; Ausanio, G.; Iannotti, V.; Pepe, Giovanni Piero; Giordano, M.; Serra, Christophe A.

doi:10.1007/s00396-019-04496-4

Cited by 14 publications

(7 citation statements)

References 38 publications

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“…Integrating microfluidics with isolation techniques can reduce the amount of reagents, increase isolation speed and allow automation 121 . Moreover, microfluidics can be introduced to rapidly mass-synthesize uniform magnetic particles 122 and to efficiently isolate viruses using magnetic-particle-based microfluidics 123 . In addition, DNA 124 or RNA nanostructures 125 that contain complementary oligonucleotides to virus DNA or RNA could be combined with microfluidics for virus isolation.…”

Section: Possibilities For Materials Sciencementioning

confidence: 99%

A materials-science perspective on tackling COVID-19

et al. 2020

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Section: Possibilities For Materials Sciencementioning

confidence: 99%

A materials-science perspective on tackling COVID-19

et al. 2020

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“…Different forms of polymerization like miniemulsion, microemulsion, and emulsion were used in dispersion media. Emulsion polymerization has been explored and reported for iron oxide encapsulation in polystyrene particles to acquire magnetic latex particles for biomedical applications . However, these particles have nonhomogeneous encapsulation and poor encapsulation productivity, which makes it difficult or, even in some cases, impossible to produce complex structures.…”

Section: Surface Functionalization and Modification Of Mnpsmentioning

confidence: 99%

“…There is no diffusion of monomer(s) in this process, which imparts exceptional characteristics to inorganic nanoparticles, as is widely stated in the literature . By using the technique of miniemulsion polymerization, it has been widely stated that the magnetic latexes can be obtained by encapsulating IONPs through polystyrene particles that show various applications in industry and mainly in the biomedical sector . Microemulsion polymerization is the most widely spread technique to prepare well-defined stable nanoparticles of precise shape and size .…”

Section: Surface Functionalization and Modification Of Mnpsmentioning

confidence: 99%

Magnetic Nanoparticles: From Synthesis to Theranostic Applications

Khizar

Ahmad

Zine

et al. 2021

ACS Appl. Nano Mater.

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Over the past few years, engineered inorganic nanoparticles have been studied researched, and applied extensively in the biomedical field since resultant platforms increase the usage of the nanoparticles for particular theranostic applications. The innovation of such nanosystems has the potential to develop a theranostic mode that integrates both diagnosis and treatment of diseases in a particular system via combinatorial approaches of imaging, targeting, and therapy that accomplish the potential of personalized and tailored medicine. The manipulation of magnetic nanoparticles (MNPs) as theranostic agents have attained growing consideration in material science owing to their exclusive capability in magnetic targeting, magnetic resonance imaging, chemotherapy, hyperthermia, bioseparation, gene therapy, enzyme immobilization, and controlled release of the drug. To intensify the diagnostic and therapeutic efficacy, MNPs have been ornamented or functionalized with a range of materials to enhance the biocompatibility, stability, and capability to carry therapeutic payloads and to encapsulate imaging agents. Preferentially synthetic and natural polymers have been exploited to coat for ensuring their colloidal stability and good dispersibility in biological fluids. Stimuli-responsive polymers have also been used to functionalize MNPs to establish a therapeutic approach that can significantly enhance therapeutic effectiveness including the real-time monitoring in specific cells and tissues. The present review highlights the progress of MNPs emphasizing functionalization using diverse inorganic and organic and biomaterials. Furthermore, it also provides the soundproof concept on the potential of MNPs and their colloidal counterparts that offer attractive possibilities for theranostic applications. Finally, the main challenges and limitations in the use of MNPs for advanced biomedical applications have also been critically provided.

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“…By fabrication of microchips, crystal colloids are being produced in controlled fashion, rapidly and economically. Few colloidal nanoparticles synthesized by using microfluidic approach are given in Table 3 [61,[71][72][73][74].…”

Section: Colloidal Nanoparticles Synthesismentioning

confidence: 99%

“…Nanocomposites acquired by miniemulsion batch process possess high content of nanoparticles of magnetite with broad distribution in size. However, nanocomposites acquired by microfluidic strategy are homogenous, but content of magnetite is lower [71]. Hence, the microfluidic system provides an exceptional product worth with considerable control over parameters allowing automation of process along with conserving performance.…”

Section: Colloidal Nanoparticles Synthesismentioning

confidence: 99%

Microfluidic‐based nanoparticle synthesis and their potential applications

et al. 2021

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Microfluidic-based nanoparticle synthesis and their potential applicationsA lot of substantial innovation in advancement of microfluidic field in recent years to produce nanoparticle reveals a number of distinctive characteristics, for instance, compactness, controllability, fineness in process, and stability along with minimal reaction amount. Recently, a prompt development, as well as realization in the production of nanoparticles in microfluidic environment having dimension of micro to nanometers and constituents extending from metals, semiconductors to polymers, has been made. Microfluidics technology integrates fluid mechanics for the production of nanoparticles having exclusive with homogenous sizes, shapes, and morphology, which are utilized in several bioapplications such as biosciences, drug delivery, and healthcare including food engineering. Nanoparticles are usually well-known for having fine and rough morphology because of their small dimensions including exceptional physical, biological, chemical, and optical properties. Though the orthodox procedures need huge instruments, costly autoclaves, use extra power, extraordinary heat loss, as well as take surplus time for synthesis. Additionally, this is fascinating to systematize, assimilate, in addition, to reduce traditional tools onto one platform to produce micro and nanoparticles. The synthesis of nanoparticles by microfluidics permits fast handling besides better efficacy of method utilizing the smallest components for process. Herein, we will focus on synthesis of nanoparticles by means of microfluidic devices intended for different bioapplications.

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Fabrication of polystyrene-encapsulated magnetic iron oxide nanoparticles via batch and microfluidic-assisted production

Cited by 14 publications

References 38 publications

A materials-science perspective on tackling COVID-19

A materials-science perspective on tackling COVID-19

Magnetic Nanoparticles: From Synthesis to Theranostic Applications

Microfluidic‐based nanoparticle synthesis and their potential applications

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