Fabrication of polyurethane and polyurethane based composite fibres by the electrospinning technique for soft tissue engineering of cardiovascular system

Kucińska-Lipka, Justyna; Gubańska, Iga; Janik, Helena; Sienkiewicz, Maciej

doi:10.1016/j.msec.2014.10.027

Cited by 185 publications

(128 citation statements)

References 69 publications

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“…Di erent natural and synthetic materials have been used for the manufacture of three-dimensional sca olds [7][8][9][10]. Since the sizes of the majority of components of the extracellular matrix, such as porosities and the diameters of the bers comprising them, are at nano-scales, use of nano-bers in tissue engineering has drawn a lot of attention in recent years [11][12][13]. Di erent techniques are available for the synthesis of nano-scale bers of which the electrospinning technique is more important than others due to its controllability and low cost.…”

Section: Introductionmentioning

confidence: 99%

Effect of Multi-wall Carbon Nanotubes(MWNTs) on Structural and Mechanical Properties of Poly(3-hydroxybutirate) Electrospun Scaffolds for Tissue Engineering Applications

2016

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Abstract. The aim of this study is to evaluate the e ects of Multi-Walled Carbon NanoTubes (MWNTs) on the structural and mechanical properties of poly-3-hydroxybutyrate (P3HB) electrospun sca olds. To achieve optimal properties of the electrospinning machine, P3HB polymer solutions were prepared at di erent concentrations and spinned in di erent electrospinning parameters. After optimization, MWNTs in di erent weight percentages (0.5%, 0.75%, 1%, and 1.25%) were added to the polymer solutions and electrospinned. The e ects of MWNTs on the structure of bers were investigated using Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR) techniques. The addition of MWNTs increased the average ber diameter from 210 (neat P3HB) to 700 nm at 1.25% MWNTs. In addition, SEM photomicrographs and the MATLAB software program showed an increase in porosity from 81% to 84% in the presence of MWNTs. Tensile strength of P3HB/MWNTs composites revealed 158% improvement over pure P3HB sca old. According to mechanical and structural properties, the best amount of MWNTs was 0.5 wt%. Therefore, MWNTs with low percentages can signi cantly improve the mechanical properties of pure P3HB sca old, so that they can become favorable mechanically for tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Effect of Multi-wall Carbon Nanotubes(MWNTs) on Structural and Mechanical Properties of Poly(3-hydroxybutirate) Electrospun Scaffolds for Tissue Engineering Applications

2016

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“…Los PUs empleados como materiales biomédicos deben cumplir con las propiedades mecánicas para la aplicación destino, deben ser no tóxicos, ser biodegradables de acuerdo con la función a cumplir y deben ser biocompatibles. 9,10 Se han utilizado estrategias para mejorar falencias de estos materiales como las propiedades de fatiga, control de la degradación, incremento de proliferación celular, entre otros. Algunas de estas estrategias consisten en modificar la superficie de los PUs por medio de procesos físicos o químicos.…”

Section: Introductionunclassified

Actividad antibacteriana, degradación hidrolítica y microbiana y citotoxicidad in vitro de poliuretanos sintetizados con polioles derivados del aceite de higuerilla

Uscátegui¹,

Díaz²,

Valero³

2016

Quim. Nova

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ANTIBACTERIAL ACTIVITY, HYDROLYTIC AND MICROBIAL DEGRADATION AND in vitro CYTOTOXICITY OF POLYURETHANE SYNTHESIZED WITH POLYOLS FROM CASTOR OIL DERIVATIVES. Biological activities from polyurethanes (PUs) synthesized from polyols (derived from castor oil) and isophorone diisocyanate were evaluated. In vitro degradability was evaluated by phosphate buffered saline (PBS) and antibacterial degradation with Escherichia coli and Pseudomonas aeruginosa. The biocompatibility was analyzed by: i) the antimicrobial activity against E. coli, S. aureus and P. aeruginosa, and ii) in vitro cytotoxicity assays using mouse embryonic fibroblast cell line L-929 in direct contact with the PUs and with NIH/3T3 cells in indirect contact with the PUs degradation products. PUs with polyol P1 (2,64% molar relation of pentaerythritol and castor oil) was the material with better biodegradation properties: 1.125±0.110% in 72 h by PBS at 100 °C. In general, all materials were degraded up to 1.000±0.223% and 2.251±0.010% in 72 h by E. coli and P. aeruginosa, respectively. On the other hand, it was determined a close relationship between functionality of polyol and bacterial inhibition. The antibacterial effect of the PUs decreased by 67% for E. coli, 55% for S. aureus and 56% for P. aeruginosa after 24 h. Chemical modification of castor oil did not generate a cytotoxic effect on the tested cell lines. The evaluated materials are suggested as candidates to obtain biomaterials due to their mechanical properties and biocompatibility presented in untransformed cells.Keywords: castor oil; polycaprolactone; cytotoxicity; degradability; biomedical applications. INTRODUCCIÓNLos poliuretanos (PUs) representan una popular e importante parte de productos industriales que se caracterizan por tener buenas propiedades de flexibilidad, elevada resistencia al impacto y durabilidad, características que lo convierten en polímeros con múltiples aplicaciones. 1 Su carácter de copolímero en bloque los dota de una amplia versatilidad en términos de adaptación de sus propiedades físicas y compatibilidad. 2-7 Es así como los PUs son interesantes para usos internos (in vivo), especialmente en aplicaciones a corto plazo, como catéteres o implantes. De igual forma, son interesantes para aplicaciones de uso externo (in vitro), como por ejemplo los sistemas de liberación controlada de medicamentos. 8 De esta forma los PUs son polímeros sintéticos biocompatibles que se emplean en dispositivos médicos y en aplicaciones de ingeniería de tejidos. Los PUs empleados como materiales biomédicos deben cumplir con las propiedades mecánicas para la aplicación destino, deben ser no tóxicos, ser biodegradables de acuerdo con la función a cumplir y deben ser biocompatibles. 9,10 Se han utilizado estrategias para mejorar falencias de estos materiales como las propiedades de fatiga, control de la degradación, incremento de proliferación celular, entre otros. Algunas de estas estrategias consisten en modificar la superficie de los PUs por medio de procesos físicos o químicos. 11 La eval...

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“…Properly engineered scaffolds should ideally reflect properties of tissues that are intended to be replaced. Biomaterials, used for tissues regeneration, should exhibit complex, mechanically anisotropic behavior optimized for their physiological function [5]. TE requires not only suitable biomaterials for scaffold design but also a suitable technique of scaffold fabrication.…”

Section: Introductionmentioning

confidence: 99%

“…Scaffolds designed for regeneration have been fabricated in a wide range of forms, such as sponges, meshes or films [5]. All of mentioned shapes have to possess interconnected open-cell micropores to enhance the compliance and increase transmural tissue ingrowths from the surrounding tissues [6].…”

Section: Introductionmentioning

confidence: 99%

“…The micropore-directed fabrication techniques include: electrospinning [7], thermally induced phase separation (TIPS) [8] and solvent casting-particulate leaching (SC/PL) [9,10]. Electrospinning is a unique and versatile process to produce polymeric fibres suitable for vascular graft prostheses [5]. Fibres with a variety of cross sectional shapes and sizes may be produced from different polymers.…”

Section: Introductionmentioning

confidence: 99%

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Ascorbic Acid in Polyurethane Systems for Tissue Engineering

Kucińska-Lipka¹,

St.²,

Janik³

et al. 2016

ChChT

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Abstract. The introduction of the paper was devoted to the main items of Tissue Engineering (TE) and the way of porous structure obtaining as scaffolds. Furthermore, the significant role of the scaffold design in TE was described. It was shown, that properly designed polyurethanes (PURs) find application in TE due to the proper physicochemical, mechanical and biological properties. Then the use of L-ascorbic acid (L-AA) in PUR systems for TE was described. L-AA has been applied in this area due to its suitable biological characteristics and antioxidative properties. Moreover, L-AA influences tissue regeneration due to improving collagen synthesis, which is a primary component of the extracellular matrix (ECM). Modification of PUR with L-AA leads to the materials with higher biocompatibility and such system is promising for TE applications.

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Fabrication of polyurethane and polyurethane based composite fibres by the electrospinning technique for soft tissue engineering of cardiovascular system

Cited by 185 publications

References 69 publications

Effect of Multi-wall Carbon Nanotubes(MWNTs) on Structural and Mechanical Properties of Poly(3-hydroxybutirate) Electrospun Scaffolds for Tissue Engineering Applications

Effect of Multi-wall Carbon Nanotubes(MWNTs) on Structural and Mechanical Properties of Poly(3-hydroxybutirate) Electrospun Scaffolds for Tissue Engineering Applications

Actividad antibacteriana, degradación hidrolítica y microbiana y citotoxicidad in vitro de poliuretanos sintetizados con polioles derivados del aceite de higuerilla

Ascorbic Acid in Polyurethane Systems for Tissue Engineering

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