Fabrication of polyvinyl pyrrolidone-K90/Eudragit RL100-based dissolving microneedle patches loaded with alpha-arbutin and resveratrol for skin depigmentation

Aung, Nway Nway; Pengnam, Supusson; Rojanarata, Theerasak; Patrojanasophon, Prasopchai; Opanasopit, Praneet; Ngawhirunpat, Tanasait; Pamornpathomkul, Boonnada

doi:10.1039/d3bm00132f

Cited by 8 publications

(2 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the low absorption and poor solubility of resveratrol, studies have also been conducted to increase the bioavailability of this compound through the use of dissolving microneedle patches. Both in vitro and in vivo studies revealed that the use of these patches effectively improved intradermal resveratrol delivery compared to a cream formulation; therefore, it can be concluded that this approach is a promising way for the effective local delivery of whitening ingredients in the melasma treatment [139].…”

Section: Musa Sapientum Rejected Unripe Fruit Extractsmentioning

confidence: 99%

Cosmetic and Pharmaceutic Products with Selected Natural and Synthetic Substances for Melasma Treatment and Methods of Their Analysis

Wawrzyńczak

2023

Cosmetics

View full text Add to dashboard Cite

Melasma is a fairly common condition that is the result of hyperpigmentation caused by increased melanin secretion. In the course of melasma, certain areas of the skin become darker than the rest of the epidermis. Although the pathogenesis remains incompletely clarified, several contributing factors have been identified, namely exposure to ultraviolet and visible light, family predisposition, pregnancy, and the use of exogenous hormones. Since current beauty standards associate healthy skin with its flawless and uniform color, people strive to eliminate any unaesthetic discoloration. Cosmetic and pharmaceutical products containing active substances with a whitening effect then become helpful. The most commonly used for this purpose are hydroquinone, arbutin, retinoids, organic acids (e.g., kojic, azelaic, and ellagic), and vitamins (B3, C, and E). However, the undesirable side effects they cause and the drive to replace synthetic chemicals with their natural counterparts have resulted in numerous reports on extracts of natural origin that exhibit skin-whitening effects. The purpose of this paper is to review the most recent scientific literature, which presents active substances of natural and synthetic origin with potential for the treatment of melasma. In addition, analytical techniques that can be used for qualitative and quantitative analysis of these substances present in cosmetic and pharmaceutical products will also be presented.

show abstract

Section: Musa Sapientum Rejected Unripe Fruit Extractsmentioning

confidence: 99%

Cosmetic and Pharmaceutic Products with Selected Natural and Synthetic Substances for Melasma Treatment and Methods of Their Analysis

Wawrzyńczak

2023

Cosmetics

View full text Add to dashboard Cite

show abstract

“…Additionally, the dose reduction index (DRI) was calculated as the ratio of the dose of each drug used in combination with the dose of that drug when administered alone to achieve the same Fa level. A DRI value > 1 suggests that the dose of the drug can be reduced in combination therapy without compromising the desired therapeutic effect [50].…”

Section: Analysis Of Dual Therapy By Compusyn Softwarementioning

confidence: 99%

Dual-Targeted Therapy in HER2-Overexpressing Breast Cancer with Trastuzumab and Novel Cholesterol-Based Nioplexes Silencing Mcl-1

Pengnam,

Opanasopit,

Rojanarata

et al. 2023

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

The challenge in HER2-overexpressing breast cancer therapy lies in creating an effective target therapy to overcome treatment resistance. Monoclonal antibodies and target gene silencing by siRNA are two potential strategies that have been widely developed for treating HER2-positive breast cancer. The siRNA delivery system is a crucial factor that influences siRNA therapy’s success. In this study, lipid-based nanoparticles (cationic niosomes) composed of different cholesterol-based cationic lipids were formulated and characterized for delivering siRNA into HER2-overexpressing breast cancer cells. Niosomes containing a trimethylammonium headgroup showed the highest siRNA delivery efficiency with low toxicity. The myeloid cell leukemia-1 (Mcl-1) siRNA nioplex treatment significantly decreased mRNA expression and breast cancer cell growth. Dual-targeted therapy, consisting of treatment with an Mcl-1 siRNA nioplex and trastuzumab (TZ) solution, noticeably promoted cell-growth inhibition and apoptosis. The synergistic effect of dual therapy was also demonstrated by computer modeling software (CompuSyn version 1.0). These findings suggest that the developed cationic niosomes were effective nanocarriers for siRNA delivery in breast cancer cells. Furthermore, the Mcl-1 nioplex/TZ dual treatment establishes a synergistic outcome that may have the potential to treat HER2-overexpressing breast cancer.

show abstract

Progress of Arbutin from Dietary Supplement to Advanced Medicine

Mishra,

Ahsan,

Mahmood

et al. 2024

eFood

View full text Add to dashboard Cite

Arbutin, a naturally occurring hydroquinone, has gained attention for its diverse pharmacological properties. Traditional uses include blood sugar regulation and wound healing, while modern applications focus on its antioxidant and anti‐inflammatory effects. Its synthesis involves complex biochemical pathways, contributing to its unique characteristics. Pharmacokinetic studies have shed light on its absorption, distribution, metabolism, and excretion, crucial for understanding its efficacy. Toxicity concerns underscore the need for further research into its safety. Additionally, novel dosage forms of arbutin are explored, presenting innovative strategies to enhance its delivery and efficacy in therapeutic applications. Arbutin's pharmacological activities span antioxidant, anti‐inflammatory, and glucose metabolism regulation thus modulating various molecular pathways and targets, such as glucose transporter‐4, insulin‐like growth factor‐1 receptor, and adenosine monophosphate‐activated protein kinase, offering promising therapeutic avenues in medicine. This review covers arbutin comprehensively, encompassing its sources, chemical properties, synthesis methods, pharmacokinetics, pharmacological activities, food supplements, toxicity profiles, and novel dosage forms. By addressing these aspects, the review lays the groundwork for future research and development in natural therapeutics.

show abstract

Fabrication of polyvinyl pyrrolidone-K90/Eudragit RL100-based dissolving microneedle patches loaded with alpha-arbutin and resveratrol for skin depigmentation

Abstract: Alpha-arbutin (AA) and resveratrol (Res) are widely used in skin-lightening products. However, current topical formulations have minimal skin-lightening effects due to low absorption and poor solubility of these active compounds....

Cited by 8 publications

References 76 publications

Cosmetic and Pharmaceutic Products with Selected Natural and Synthetic Substances for Melasma Treatment and Methods of Their Analysis

Cosmetic and Pharmaceutic Products with Selected Natural and Synthetic Substances for Melasma Treatment and Methods of Their Analysis

Dual-Targeted Therapy in HER2-Overexpressing Breast Cancer with Trastuzumab and Novel Cholesterol-Based Nioplexes Silencing Mcl-1

Progress of Arbutin from Dietary Supplement to Advanced Medicine

Contact Info

Product

Resources

About