Fabrication of Porous Crystalline PLGA-PEG Induced by Swelling during the Recrystallization Annealing Process

Dai, Jidong; Tan, Xin; Min, Liang; Wei, Dandan; Tao, Yinhua; Ren, Pengfei; Zhang, Tianzhu

doi:10.1021/acsbiomaterials.1c01187

Cited by 6 publications

(1 citation statement)

References 39 publications

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“…So far, the properties of PEG/PLLA block copolymers with different architectures have been designed and investigated by other research groups, e.g., PEG-b-PLLA diblock copolymers, 27 PLLA-b-PEG-b-PLLA triblock copolymers, 28,29 PLLA-b-PEG-b-PDLA triblock copolymers, 30 and star-shaped PLLA-b-PEG block copolymers. 31,32 These copolymers with different architectures and different compositions have been little studied with respect to the morphological structure and thermal properties with the corresponding crystallization behavior. The potential of PEG-b-PLLA multiblock copolymers is still significant.…”

Section: Introductionmentioning

confidence: 99%

Role of the branched PEG-b-PLLA chain in morphological structures and thermodynamics for PEG-b-PLLA-g-glucose copolymers with different architectures

Guo

et al. 2023

New J. Chem.

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Section: Introductionmentioning

confidence: 99%

Role of the branched PEG-b-PLLA chain in morphological structures and thermodynamics for PEG-b-PLLA-g-glucose copolymers with different architectures

Guo

et al. 2023

New J. Chem.

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Fabricating Biodegradable Tissue Scaffolds Through a New Aggregation Triggered Physical Cross‐Linking Strategy of Hydrophilic and Hydrophobic Polymers

Kaga,

Kaga

2024

Macro Materials & Eng

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In the study, a new strategy is presented to make PLGA (poly lactic‐co‐glycolic acid) and POEGMEMA (poly(oligo(ethylene glycol) methyl ether methacrylate)) based biodegradable and biocompatible tissue scaffold via a new physical cross‐linking method. The advantage of brushed structure of POEGMEMA polymer and the hydrophobic character of PLGA polymer is taken to make physically entangled network in aqueous media. The hydrophobic nature of PLGA allows to get scaffolds even at low ratio of PLGA (25%, w/w) when using POEGMEMA (yield: 86%). This strategy gives robust polymeric networks in aqueous media without using chemical reactions through high hydrophilic polymer content. Scaffolds with high POEGMEMA ratio (75%, w/w) show two times higher water uptake ratio (≈300%) and two times lower compression strength (19 kPa) compared to the ones with lower POEGMEMA content (50%, w/w). They also show desired degradation profiles in various aqueous solutions. While the scaffolds prepared with 25% and 50% PLGA are almost stable in first 20 days, they completely degrade in 40–50 days. Both scaffold formulations (25% PLGA‐75% POEGMEMA and 50% PLGA‐50% POEGMEMA) have similar proliferative properties for fibroblast cells. The scaffolds also do not show toxicity compared to control group according to live‐dead assay.

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Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review

Hulimane Shivaswamy,

Binulal,

Benoy

et al. 2024

ACS Mater. Au

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The delivery of molecules, such as DNA, RNA, peptides, and certain hydrophilic drugs, across the epidermal barrier poses a significant obstacle. Microneedle technology has emerged as a prominent area of focus in biomedical research because of its ability to deliver a wide range of biomolecules, vaccines, medicines, and other substances through the skin. Microneedles (MNs) form microchannels by disrupting the skin's structure, which compromises its barrier function, and facilitating the easy penetration of drugs into the skin. These devices enhance the administration of many therapeutic substances to the skin, enhancing their stability. Transcutaneous delivery of medications using a microneedle patch offers advantages over conventional drug administration methods. Microneedles containing active substances can be stimulated by different internal and external factors to result in the regulated release of the substances. To achieve efficient drug administration to the desired location, it is necessary to consider the design of needles with appropriate optimized characteristics. The choice of materials for developing and manufacturing these devices is vital in determining the pharmacodynamics and pharmacokinetics of drug delivery. This article provides the most recent update and overview of the numerous microneedle systems that utilize different activators to stimulate the release of active components from the microneedles. Further, it discusses the materials utilized for producing microneedles and the design strategies important in managing the release of drugs. An explanation of the commonly employed fabrication techniques in biomedical applications and electronics, particularly for integrated microneedle drug delivery systems, is discussed. To successfully implement microneedle technology in clinical settings, it is essential to comprehensively assess several factors, such as biocompatibility, drug stability, safety, and production cost. Finally, an in-depth review of these criteria and the difficulties and potential future direction of microneedles in delivering drugs and monitoring diseases is explored.

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Fabrication of Porous Crystalline PLGA-PEG Induced by Swelling during the Recrystallization Annealing Process

Cited by 6 publications

References 39 publications

Role of the branched PEG-b-PLLA chain in morphological structures and thermodynamics for PEG-b-PLLA-g-glucose copolymers with different architectures

Role of the branched PEG-b-PLLA chain in morphological structures and thermodynamics for PEG-b-PLLA-g-glucose copolymers with different architectures

Fabricating Biodegradable Tissue Scaffolds Through a New Aggregation Triggered Physical Cross‐Linking Strategy of Hydrophilic and Hydrophobic Polymers

Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review

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