Fabrication of Pure Electrospun Materials from Hyaluronic Acid

Pabjańczyk-Wlazło, Ewelina; Krucińska, Izabella; Chrzanowski, M.; Szparaga, Grzegorz; Chaberska, Agata; Kolesińska, Beata; Komisarczyk, Agnieszka; Boguń, Maciej

doi:10.5604/01.3001.0010.1688

Cited by 11 publications

(11 citation statements)

References 19 publications

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“…Electrostatic spinning solution of FHHA‐S was prepared by dissolving HHA (15 mg) and HHA‐S (15 mg) in a solution consisting of 25% AW (1.8 mL) and NMP (0.6 mL). [ 24 ] The polymer stream was fed through a needle of 0.6 mm diameter at a flow rate of 1 mL h −1 . The collector was kept 15 cm apart from the needle tip.…”

Section: Methodsmentioning

confidence: 99%

Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing

Zhang

et al. 2020

Adv Healthcare Materials

162

103

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Current standard of care dressings are unsatisfactorily inefficacious for the treatment of chronic wounds. Chronic inflammation is the primary cause of the long‐term incurable nature of chronic wounds. Herein, an absorbable nanofibrous hydrogel is developed for synergistic modulation of the inflammation microenvironment to accelerate chronic diabetic wound healing. The electrospun thioether grafted hyaluronic acid nanofibers (FHHA‐S/Fe) are able to form a nanofibrous hydrogel in situ on the wound bed. This hydrogel degrades and is absorbed gradually within 3 days. The grafted thioethers on HHA can scavenge the reactive oxygen species quickly in the early inflammation phase to relieve the inflammation reactions. Additionally, the HHA itself is able to promote the transformation of the gathered M1 macrophages to the M2 phenotype, thus synergistically accelerating the wound healing phase transition from inflammation to proliferation and remodeling. On the chronic diabetic wound model, the average remaining wound area after FHHA‐S/Fe treatment is much smaller than both that of FHHA/Fe without grafted thioethers and the control group, especially in the early wound healing stage. Therefore, this facile dressing strategy with intrinsic dual modulation mechanisms of the wound inflammation microenvironment may act as an effective and safe treatment strategy for chronic wound management.

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Section: Methodsmentioning

confidence: 99%

Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing

Zhang

et al. 2020

Adv Healthcare Materials

162

103

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“…Thus it is very difficult to compare average values when the dispersions of diameters are different. The main problem is that the measurements of the diameter are distributed in an unclear distribution and characterising webs mathematically and evaluating the shape of the distribution obtained are not easy [59,60]. The different thickness of fibres influences the structure of the web and herewith the end-use properties of such kind of nanomaterial [61,62].…”

Section: Nanofibrous Web Structure Estimationmentioning

confidence: 99%

Electrospinning – 100 Years of Investigations and Still Open Questions of Web Structure Estimination

Kleivaitė

Milašius

2018

Autex Research Journal

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The article presents an overview of electrospinning process development from the first investigations in the field of behaviour of liquids in an electrostatic field to the electrospinning methods and investigations in the 21st century. The article presents the history of electrospinning process development, the main problems that are solved, and also indicates the gaps in the field of standardisation of nanofibrous web structure measurement and estimation. There are a lot of works in which authors analyse influences of various parameters on the electrospinning process or on the structure of electrospun web, whereas the majority of them do not analyse the quality of structure using mathematical criteria. Such a situation leads to different conclusions and makes it impossible to compare various works by different authors. Despite numerous studies in electrospinning, investigations in the electrospun nanofibrous web estimation are not sufficient. Until now, a unique standard method for measuring and estimating the fibre diameter and web porosity has not been developed. The necessity of such a method and standards is obvious, and the lack of such a standard could have a negative influence on the electrospun product introduction into the market.

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“…Aqueous solutions of hyaluronic acid have high levels of electrical conductivity and viscosity, coupled with low volatility. All the above-mentioned factors hinder the electrospinning process [ 7 , 8 , 9 , 10 ]. For example, wet nanofibers with the unevaporated water could function as conductors among the electrodes, leading to the probability of an “electric breakdown” [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin/Usnic Acid-Loaded Electrospun Nanofibers Based on Hyaluronic Acid

et al. 2020

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Hyaluronic acid, curcumin, and usnic acid are separately utilized as effective biological agents in medicine, and materials based on its blend are considered to have wider therapeutic effects than individual ones. In this study, for the first time, native hyaluronic acid-based fibers containing curcumin and usnic acid with an average diameter of 298 nm were successfully prepared by the electrospinning technique and characterized. Additionally, unstable and hydrophobic curcumin and usnic acid were loaded into the hydrophilic hyaluronic acid matrix without utilizing the activating (catalyzing) agents, resulting in the formation of an electrospinnable solution. Only the binary mixture deionized water—dimethyl sulfoxide (50:50)—was used as solvent. The presence of small amounts of dimethyl sulfoxide in the fibrous materials was expected to provide the materials with local anesthetic and antiseptic activity. The effect of electric voltage on the electrospinning process, diameter, and morphology of hyaluronic acid/curcumin/usnic acid fibers was investigated in detail. The impact of curcumin and usnic acid on the stability of fiber formation was observed. The investigation of fibers based on pure hyaluronic acid without additional polymers and with active pharmaceutical ingredients will lay the groundwork for the development of highly effective wound dressings and new drug delivery scaffolds.

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Fabrication of Pure Electrospun Materials from Hyaluronic Acid

Cited by 11 publications

References 19 publications

Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing

Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing

Electrospinning – 100 Years of Investigations and Still Open Questions of Web Structure Estimination

Curcumin/Usnic Acid-Loaded Electrospun Nanofibers Based on Hyaluronic Acid

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