Fabrication of radiation cross-linked diclofenac sodium loaded carboxymethyl sago pulp/chitosan hydrogel for enteric and sustained drug delivery

Tan, Linling; Tan, Hui; Deekonda, Karthik; Wong, Yeon Yin; Muniyandy, Saravanan; Hashim, Kamaruddin; Pushpamalar, Janarthanan

doi:10.1016/j.carpta.2021.100084

Cited by 21 publications

(14 citation statements)

References 59 publications

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“…In the FT‐IR spectrum of drug‐loaded AX/CS blends (Figure 8 B, C, and D), various characteristic peaks of AX, CS, and DS appeared without any significant shifting of the peaks, suggesting no interaction between DS and the polymers (AX and CS) used. Same in the case of drug‐loaded OAX/CS blends shown in Figure 8 (E, F, and G), all significant peaks were almost the same as described above except a major peak of periodate oxidation at 1716 cm −1 , a characteristic peak for carbonyl groups [55–57] …”

Section: Resultssupporting

confidence: 59%

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Functionalization of Arabinoxylan in Chitosan Based Blends by Periodate Oxidation for Drug Release Study

Jabeen,

Iram,

Atif

et al. 2024

ChemistrySelect

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This article presents the isolation of arabinoxylan (AX) from Plantago ovata seed husk and its oxidation using periodate to create oxidized‐AX (OAX) with distinct functionalities. Utilizing the solution casting method, biocompatible blends of arabinoxylan/chitosan (AX/CS) are prepared at various weight ratios, and their properties are assessed. Fourier transform infrared spectroscopy (FT‐IR), x‐ray diffraction (XRD), and thermogravimetric analysis (TGA) are employed to gauge compatibility and thermal traits of AX and OAX with CS. Solubility tests reveal partial and limited solubility of AX and OAX in distilled water, respectively. OAX displays favorable compressibility and flow rate through Carr's index, Hausner's ratio, and angle of repose analyses. FT‐IR data confirm intermolecular hydrogen bonding between CS′s −NH2− group and OAX′s carbonyl group, with XRD showing low crystallinity. Diclofenac sodium (DC) is loaded as a model drug into AX/CS and OAX/CS blends for release studies in pH 6.8 phosphate buffer. Results exhibit OAX/CS blends with sustained drug release, surpassing AX/CS blends. Among ratios tested, the OAX/CS (1 : 2) blend emerges as a superior excipient, demonstrating enhanced in‐vitro release potential, highlighting oxidized blends′ promise in sustained drug delivery systems.

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Section: Resultssupporting

confidence: 59%

“…Same in the case of drug-loaded OAX/CS blends shown in Figure 8 (E, F, and G), all significant peaks were almost the same as described above except a major peak of periodate oxidation at 1716 cm À 1 , a characteristic peak for carbonyl groups. [55][56][57]…”

Section: Diclofenac Sodium As a Model Drugmentioning

confidence: 99%

Functionalization of Arabinoxylan in Chitosan Based Blends by Periodate Oxidation for Drug Release Study

Jabeen,

Iram,

Atif

et al. 2024

ChemistrySelect

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“…Finally, zinc oxide is chelated with the amine groups of polyacrylamide. This mechanism is proposed by other investigators for irradiation crosslinking of different carbohydrate polymers [27,28]. The photochemical initiation and crosslinking is highly favoured over thermochemical process, particualry at adjusted dose and controlled conditions.…”

Section: Synthesis Of Green Compositesmentioning

confidence: 75%

Radiation Synthesis of Green Nanoarchitectonics of Guar Gum-Pectin/Polyacrylamide/Zinc Oxide Superabsorbent Hydrogel for Sustainable Agriculture

Sayed

Mohamed

Abdel-Raouf

et al. 2022

J Inorg Organomet Polym

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In the current study, the performance of superabsorbent hydrogel composites comprised of Guar gum-Pectin/Polyacrylamide/ZnO crosslinked with gamma irradiation (10 kGy) has been investigated for sustainable agriculture. The claimed composites (GG/PC/PAAm/ZnOx) were characterized by FTIR, TGA, and AFM. The swelling capacity data reveal that the equilibrium water swelling (EW) of the composites was increased by increasing the ZnO content from 600 to 1050 g/g for zero to the highest concentration of ZnO, respectively. Furthermore, the physical properties of the soil mixed with the hydrogels were improved; water holding capacity (WHC) increased to 66% and water retention (WR) kept at 15% after 20 days. The composites showed a good degradability in the biodegradation test. They also portrayed super-absorption capacity at three swelling/deswelling cycles. This advancement is important for reducing water consumption through the irrigation of arid lands. The prepared composites were proved as excellent candidates in sustainable agriculture applications.

show abstract

“…Finally, zinc oxide is chelated with the amine groups of polyacrylamide. This mechanism is proposed by other investigators for irradiation crosslinking of different carbohydrate polymers 34,35 . The photochemical initiation and crosslinking is highly favoured over thermochemical process, particualry at adjusted dose and controlled conditions.…”

Section: Synthesis Of Green Compositesmentioning

confidence: 63%

Radiation green synthesis of Guar gum -Pectin/ Polyacrylamide/ zinc oxide superabsorbent hydrogel composites for sustainable agriculture

Sayed

Mohamed

Abdel-Raouf

et al. 2022

Preprint

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In the current study, the performance of superabsorbent hydrogel composites comprised of Guar gum-Pectin/ Polyacrylamide/ ZnO crosslinked with gamma irradiation (10 kGy) has been investigated for sustainable agriculture. The claimed composites (GG/PC/PAAm/ZnOx) were characterized by FTIR, TGA, and AFM. The swelling capacity data reveal that the equilibrium water swelling (EW) of the composites was increased by increasing the ZnO content from 600 g/g to 1050 g/g for zero to the highest concentration of ZnO, respectively. Furthermore, the physical properties of the soil mixed with the hydrogels were improved; water holding capacity (WHC) increased to 66% and water retention (WR) kept at 15% after 20 days. The composites showed a good degradability in the biodegradation test. They also portrayed super-absorption capacity at three swelling/deswelling cycles. This advancement is important for reducing water consumption through the irrigation of arid lands. The prepared composites were proved as excellent candidates in sustainable agriculture applications.

show abstract

Fabrication of radiation cross-linked diclofenac sodium loaded carboxymethyl sago pulp/chitosan hydrogel for enteric and sustained drug delivery

Cited by 21 publications

References 59 publications

Functionalization of Arabinoxylan in Chitosan Based Blends by Periodate Oxidation for Drug Release Study

Functionalization of Arabinoxylan in Chitosan Based Blends by Periodate Oxidation for Drug Release Study

Radiation Synthesis of Green Nanoarchitectonics of Guar Gum-Pectin/Polyacrylamide/Zinc Oxide Superabsorbent Hydrogel for Sustainable Agriculture

Radiation green synthesis of Guar gum -Pectin/ Polyacrylamide/ zinc oxide superabsorbent hydrogel composites for sustainable agriculture

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