In this study, we demonstrate that
an optimal design of the pore
geometry and shape of sensing platforms based on nanoporous anodic
alumina (NAA) photonic structures is critical to develop optical sensors
with improved capabilities. To this end, two types of NAA photonic
structures featuring different pore geometries (i.e., pore lengths
and diameters) and shapes (i.e., straight and modulated pores) were
produced, and their optical characteristics were assessed systematically
by reflectometric interference spectroscopy. The geometric features
(i.e., pore lengths, diameters, and shapes) were systematically modified
in order to establish the optimization paths for the sensitivity,
low limit of detection, and linearity of these optical sensing platforms.
The obtained results reveal that an optimal design of these nanoporous
photonic structures can enhance their sensitivity, achieve a lower
limit of detection, and improve their linearity for both nonspecific
and specific detection of analytes. Therefore, as this study demonstrates,
the rational design of optical nanoporous sensing platforms is critical
in the development of reliable, sensitive, robust, inexpensive, and
portable optical systems for a broad range of sensing applications.