Fabrication of sliver nanoparticles/polyvinyl alcohol/gelatin ternary nanofiber mats for wound healing application

Amer, Somaya A.; Attia, Noha; Nouh, Samir R.; El-Kammar, Mahmoud H.; Korittum, Ahmed S.; Abu-Ahmed, Howaida M.

doi:10.1177/0885328220927317

Cited by 28 publications

(11 citation statements)

References 45 publications

(81 reference statements)

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“…Moreover, the antibacterial performance was also notably enhanced due to the encapsulation of Fe 3 O 4 nanoparticles. The existing studies also reported the design and development of electrospun ternary nanofiber mats with different multifunctional performances for wound dressing applications, such as ferric oxide/gelatin/glycerol nanofiber mats [ 116 ], copper oxide nanoparticle/gelatin/PCL nanofiber mats [ 117 ], cerium oxide nanoparticle/gelatin/PCL nanofiber mats [ 118 ], sliver nanoparticle/gelatin/PVA nanofiber mats [ 119 ], tellurium nanoparticle/gelatin/PCL nanofiber mats [ 120 ], and halloysite nanotube/gelatin/PCL nanofiber mats [ 121 ].…”

Section: Electrospun Gelatin-based Nanofibersmentioning

confidence: 99%

State-of-the-Art Review of Electrospun Gelatin-Based Nanofiber Dressings for Wound Healing Applications

Sun

2022

Nanomaterials

161

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Electrospun nanofiber materials have been considered as advanced dressing candidates in the perspective of wound healing and skin regeneration, originated from their high porosity and permeability to air and moisture, effective barrier performance of external pathogens, and fantastic extracellular matrix (ECM) fibril mimicking property. Gelatin is one of the most important natural biomaterials for the design and construction of electrospun nanofiber-based dressings, due to its excellent biocompatibility and biodegradability, and great exudate-absorbing capacity. Various crosslinking approaches including physical, chemical, and biological methods have been introduced to improve the mechanical stability of electrospun gelatin-based nanofiber mats. Some innovative electrospinning strategies, including blend electrospinning, emulsion electrospinning, and coaxial electrospinning, have been explored to improve the mechanical, physicochemical, and biological properties of gelatin-based nanofiber mats. Moreover, numerous bioactive components and therapeutic agents have been utilized to impart the electrospun gelatin-based nanofiber dressing materials with multiple functions, such as antimicrobial, anti-inflammation, antioxidation, hemostatic, and vascularization, as well as other healing-promoting capacities. Noticeably, electrospun gelatin-based nanofiber mats integrated with specific functions have been fabricated to treat some hard-healing wound types containing burn and diabetic wounds. This work provides a detailed review of electrospun gelatin-based nanofiber dressing materials without or with therapeutic agents for wound healing and skin regeneration applications.

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Section: Electrospun Gelatin-based Nanofibersmentioning

confidence: 99%

State-of-the-Art Review of Electrospun Gelatin-Based Nanofiber Dressings for Wound Healing Applications

Sun

2022

Nanomaterials

161

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“…The SEM images of the hybrid nanofiber mats showed a combination of smooth, beads-free, and uniform fibrous morphologies. The in vivo studies showed an accelerated wound healing process when the full-thickness skin wounds in rabbits were treated with both hybrid nanofiber mats incorporated with nanoparticles and pristine hybrid nanofiber mats [ 111 ]. Cai et al, prepared nanofibrous membranes that are based on gelatin and PCL.…”

Section: Gelatin-based Hybrid Wound Dressingsmentioning

confidence: 99%

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

et al. 2021

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Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dressings suffer from various limitations, including poor antimicrobial activity, etc. Wound dressings that are formulated from biopolymers (e.g., cellulose, chitin, gelatin, chitosan, etc.) demonstrate interesting properties, such as good biocompatibility, non-toxicity, biodegradability, and attractive antimicrobial activity. Although biopolymer-based wound dressings display the aforementioned excellent features, they possess poor mechanical properties. Gelatin, a biopolymer has excellent biocompatibility, hemostatic property, reduced cytotoxicity, low antigenicity, and promotes cellular attachment and growth. However, it suffers from poor mechanical properties and antimicrobial activity. It is crosslinked with other polymers to enhance its mechanical properties. Furthermore, the incorporation of antimicrobial agents into gelatin-based wound dressings enhance their antimicrobial activity in vitro and in vivo. This review is focused on the development of hybrid wound dressings from a combination of gelatin and other polymers with good biological, mechanical, and physicochemical features which are appropriate for ideal wound dressings. Gelatin-based wound dressings are promising scaffolds for the treatment of infected, exuding, and bleeding wounds. This review article reports gelatin-based wound dressings which were developed between 2016 and 2021.

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“…The targeting of chronic wound biofilms of S. aureus and E. coli was successful by using nano silver-loaded polyvinyl alcohol-based fibres [ 162 ] with high mechanical stability. Both nanofiber/nanofiber-AgNPs mats are found to combat microbial invasion into the wound bed [ 163 ].…”

Section: Nanoplatforms Against Wound Biofilmsmentioning

confidence: 99%

Engineered Nanotechnology: An Effective Therapeutic Platform for the Chronic Cutaneous Wound

et al. 2022

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The healing of chronic wound infections, especially cutaneous wounds, involves a complex cascade of events demanding mutual interaction between immunity and other natural host processes. Wound infections are caused by the consortia of microbial species that keep on proliferating and produce various types of virulence factors that cause the development of chronic infections. The mono- or polymicrobial nature of surface wound infections is best characterized by its ability to form biofilm that renders antimicrobial resistance to commonly administered drugs due to poor biofilm matrix permeability. With an increasing incidence of chronic wound biofilm infections, there is an urgent need for non-conventional antimicrobial approaches, such as developing nanomaterials that have intrinsic antimicrobial-antibiofilm properties modulating the biochemical or biophysical parameters in the wound microenvironment in order to cause disruption and removal of biofilms, such as designing nanomaterials as efficient drug-delivery vehicles carrying antibiotics, bioactive compounds, growth factor antioxidants or stem cells reaching the infection sites and having a distinct mechanism of action in comparison to antibiotics—functionalized nanoparticles (NPs) for better incursion through the biofilm matrix. NPs are thought to act by modulating the microbial colonization and biofilm formation in wounds due to their differential particle size, shape, surface charge and composition through alterations in bacterial cell membrane composition, as well as their conductivity, loss of respiratory activity, generation of reactive oxygen species (ROS), nitrosation of cysteines of proteins, lipid peroxidation, DNA unwinding and modulation of metabolic pathways. For the treatment of chronic wounds, extensive research is ongoing to explore a variety of nanoplatforms, including metallic and nonmetallic NPs, nanofibers and self-accumulating nanocarriers. As the use of the magnetic nanoparticle (MNP)-entrenched pre-designed hydrogel sheet (MPS) is found to enhance wound healing, the bio-nanocomposites consisting of bacterial cellulose and magnetic nanoparticles (magnetite) are now successfully used for the healing of chronic wounds. With the objective of precise targeting, some kinds of “intelligent” nanoparticles are constructed to react according to the required environment, which are later incorporated in the dressings, so that the wound can be treated with nano-impregnated dressing material in situ. For the effective healing of skin wounds, high-expressing, transiently modified stem cells, controlled by nano 3D architectures, have been developed to encourage angiogenesis and tissue regeneration. In order to overcome the challenge of time and dose constraints during drug administration, the approach of combinatorial nano therapy is adopted, whereby AI will help to exploit the full potential of nanomedicine to treat chronic wounds.

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Fabrication of sliver nanoparticles/polyvinyl alcohol/gelatin ternary nanofiber mats for wound healing application

Cited by 28 publications

References 45 publications

State-of-the-Art Review of Electrospun Gelatin-Based Nanofiber Dressings for Wound Healing Applications

State-of-the-Art Review of Electrospun Gelatin-Based Nanofiber Dressings for Wound Healing Applications

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

Engineered Nanotechnology: An Effective Therapeutic Platform for the Chronic Cutaneous Wound

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