Fabrication of stabilized colloidal crystal monolayers

Chang, Yow-Ren; Taylor, Shane; Duncan, Scott J.; Mazilu, Dan; Ritter, Andreas

doi:10.1016/j.colsurfa.2016.11.050

Cited by 7 publications

(13 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For three independent samples, on average, only 2.4 of the 100 squares were affected with a standard deviation of 0.8, corresponding to a 4B rating in the ASTM standard (see Figure S11 ). When the tape was used to pull off the top layer of particles from an unscratched sample (a variant of the ASTM D1876 peel test 19 ), there was a 0.25% loss of coverage ( p = 0.007, six samples); visual inspection of the images showed that only a few particles were removed (see Figure S12 ). These results indicate that the film has durability.…”

Section: Resultsmentioning

confidence: 99%

A Surface Coating that Rapidly Inactivates SARS-CoV-2

Behzadinasab

Chin

Hosseini

et al. 2020

ACS Appl. Mater. Interfaces

Self Cite

191

208

View full text Add to dashboard Cite

SARS-CoV-2, the virus that causes the disease COVID-19, remains viable on solids for periods of up to 1 week, so one potential route for human infection is via exposure to an infectious dose from a solid. We have fabricated and tested a coating that is designed to reduce the longevity of SARS-CoV-2 on solids. The coating consists of cuprous oxide (Cu 2 O) particles bound with polyurethane. After 1 h on coated glass or stainless steel, the viral titer was reduced by about 99.9% on average compared to the uncoated sample. An advantage of a polyurethane-based coating is that polyurethane is already used to coat a large number of everyday objects. Our coating adheres well to glass and stainless steel as well as everyday items that people may fear to touch during a pandemic, such as a doorknob, a pen, and a credit card keypad button. The coating performs well in the cross-hatch durability test and remains intact and active after 13 days of being immersed in water or after exposure to multiple cycles of exposure to the virus and disinfection.

show abstract

Section: Resultsmentioning

confidence: 99%

A Surface Coating that Rapidly Inactivates SARS-CoV-2

Behzadinasab

Chin

Hosseini

et al. 2020

ACS Appl. Mater. Interfaces

Self Cite

191

208

View full text Add to dashboard Cite

show abstract

“…The monolayer of particles was bound to each other and to the PDMS by silica produced by a sol-gel technique. Fabrication is described in brief here and in more detail elsewhere [ 31 ]. The PDMS was prepared from Sylgard 184 components (Dow Corning, MI) and cured in a petri dish.…”

Section: Methodsmentioning

confidence: 99%

“…Coatings of colloidal particles (see Fig 1 ) are used to vary the topography by varying the diameter of the particles. Crystalline monolayers of colloidal particles are known as colloidal crystal monolayers and a method of producing robust films from monolayers of silica (SiO 2 ) colloidal crystals has been published previously [ 31 ]. Colloidal crystal monolayers with particle dimensions 0.5–8 μm have been shown to reduce the adsorption and biofilm development of the bacterium Pseudomonas aeruginosa [ 12 , 24 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of surface topography on biofilm formation by Candida albicans

2018

Self Cite

View full text Add to dashboard Cite

Candida albicans is a fungal pathogen that causes serious biofilm-based infections. Here we have asked whether surface topography may affect C. albicans biofilm formation. We tested biofilm growth of the prototypical wild-type strain SC5314 on a series of polydimethylsiloxane (PDMS) solids. The surfaces were prepared with monolayer coatings of monodisperse spherical silica particles that were fused together into a film using silica menisci. The surface topography was varied by varying the diameter of the silica particles that were used to form the film. Biofilm formation was observed to be a strong function of particle size. In the particle size range 4.0–8.0 μm, there was much more biofilm than in the size range 0.5–2.0 μm. The behavior of a clinical isolate from a clade separate from SC5314, strain p76067, showed results similar to that of SC5314. Our results suggest that topographic coatings may be a promising approach to reduce C. albicans biofilm infections.

show abstract

“…Other chemicals were: polydimethylsiloxane (PDMS) Silica CCMs were fabricated using the rubbing method with slight modifications. 50,51 Briefly, PDMS plates were prepared by mixing base and curing agent in a 10:1 mass ratio, degassed, poured into 100 mm polystyrene Petri dishes, and cured at 75 °C for 2 h. The thickness of PDMS was approximately 2.5 mm. A dry powder of silica spheres was sprinkled over the PDMS surface followed by rubbing manually with another piece of PDMS in a unidirectional manner.…”

Section: Methodsmentioning

confidence: 99%

Effects of Colloidal Crystals, Antibiotics, and Surface-Bound Antimicrobials on Pseudomonas aeruginosa Surface Density

Mon

Chang

Ritter

et al. 2017

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

We examined the effect of a crystalline layer of silica particles in the size range 0.5−4 μm on the adsorption and surface growth of Pseudomonas aeruginosa. Growth on these colloidal crystal monolayers (CCMs) was compared to growth on a flat plate of silica. All surfaces were coated with a thin film of silica to provide chemical uniformity of the different topographies. The results showed that the CCM reduces the density of colony forming units (CFU) on the solid by 99−99.9% when the suspension load was 10 3 CFU. We also examined the interaction between the CCM and either antibiotics or a chemically bound antimicrobial. The addition of 20 μg/mL tobramycin after an initial 24 h growth period caused a further decrease in CFU counts of about 99−99.9% for all topographies. The percentage reduction as a result of the antibiotics was similar for all topographies, which suggested that there was no particular synergy between the topography and antibiotics. On the other hand, the additive nature of the two effects suggested promise for clinical studies: the large percentage reduction in CFU density on addition of the antibiotic to a flat surface was maintained on the topography, even starting from a much lower CFU density. A similar result was obtained for the combination of CCM and a covalently bound layer of antimicrobial poly(allylamine hydrochloride) (PAH). The PAH reduced the CFU, and the CCM caused a further reduction; the two factors behaved approximately independently. Overall the CCM was found to be very effective at reducing the density of adsorbed P. aeruginosa both with and without the additional reductions caused by antibiotics or surface-bound antimicrobials.

show abstract

Fabrication of stabilized colloidal crystal monolayers

Cited by 7 publications

References 29 publications

A Surface Coating that Rapidly Inactivates SARS-CoV-2

A Surface Coating that Rapidly Inactivates SARS-CoV-2

Impact of surface topography on biofilm formation by Candida albicans

Effects of Colloidal Crystals, Antibiotics, and Surface-Bound Antimicrobials on Pseudomonas aeruginosa Surface Density

Contact Info

Product

Resources

About