Fabrication of targeted gold nanoparticle as potential contrast agent in molecular CT imaging

Malekzadeh, Reza; Ghorbani, Marjan; Faghani, Parsa; Abdollahi, Behnaz Babaye; Mortezazadeh, Tohid; Farhood, Bagher

doi:10.1016/j.jrras.2022.100490

Cited by 16 publications

(6 citation statements)

References 26 publications

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“…In particular, the current work showed that LP can functionalize GNP and that this can lead to preferential delivery and improved radiosensitization in cancerous cells that overexpress SSTR2 [95]. The AuNPs produced having a dimension of less than 100 nm were found to be benign at certain concentration levels and to demonstrate a higher X-ray attenuate amplitude at a comparable level as iodine-based contrast elements [96].…”

Section: Aunps In Folate Receptor Targetingmentioning

confidence: 71%

Chemical potential and biomedical activity of gold nanoparticles in cancer and drug delivery systems: an updat

Soni,

Solanki

2024

Vietnam J. Sci. Technol.

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Gold nanoparticles (AuNPs) are broadly utilized in medical fields because of its unique potential, biomedical activity and physicochemical properties. The biocompatible nature, optical properties, and minor cytotoxicity are the key features of AuNPs which make them valuable for biomedical applications. Today, AuNPs are widely used for cancer therapy, bioimaging, biosensing, radiotherapy, photodynamic therapy and drug delivery system. The present article illustrates the current progress in AuNPs synthesis, properties of AuNPs, various biomedical activity of AuNPs in therapeutic fields and drug delivery systems. Apart from numerous benefits the chemically synthesized AuNPs also creates certain level of toxicity in the living system which represents confronts of AuNPs against biomedical applications. Reducing its cytotoxic nature and development of green AuNPs can led to development of new history in field of medical science and clinical trials. Thus, the present review article deals with the compiled study of various fundamental research over AuNPs such as its chemical and bio-synthesis, biomedical and therapeutic applications viz. plasmonic photothermal therapy, photodynamic therapy, folate receptor targeting, targeted drug delivery etc. The article also finds some of its confronts against biomedical application because of its cytotoxic nature and its possible future prospects.

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Section: Aunps In Folate Receptor Targetingmentioning

confidence: 71%

Chemical potential and biomedical activity of gold nanoparticles in cancer and drug delivery systems: an updat

Soni,

Solanki

2024

Vietnam J. Sci. Technol.

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“…A novel development involving Trastuzumab (TZ) multifunctional Fe 3 O 4 coated Au NPs through PEG linking has emerged for targeted molecular computed tomography (CT) imaging 153 . The TZ-PEG-Fe3O4@Au NPs were meticulously characterized and evaluated for their cytocompatibility, X-ray attenuation, and in vitro cell targeting ability.…”

Section: Gold or Gold-polymer Nanoparticles For Bioimagingmentioning

confidence: 99%

Gold Polymer Nanomaterials: A Promising Approach for Enhanced Biomolecular Imaging

Kumar,

Mahajan

2024

Nanotheranostics

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Gold nanoparticles (AuNPs) possess unique optical properties, making them highly attractive nanomaterials for biomedical research. By exploiting the diverse optical characteristics of various gold nanostructures, significant enhancements can be achieved in biosensing and biomedical imaging fields. The potential of AuNPs can be enhanced by creating hybrid nanocomposites with polymers, which offer supplementary functionalities, responsiveness, and enhanced biocompatibility. Moreover, polymers can modify the surface charges of AuNPs, thereby improving or controlling the efficiency of cellular uptake and the distribution of these nanoparticles within the body. Polymer modification using AuNPs offers a wide array of benefits, including improved sensitivity, specificity, speed, contrast, resolution, and penetration depth. By incorporating AuNPs into the polymer matrix, these enhancements synergistically enhance the overall performance of various applications. This versatile approach opens promising possibilities in fields such as biomedicine, nanotechnology, and sensor development, providing a powerful platform for advanced research and technological innovations. In this review, the recent advancements in polymer-AuNPs synthesis and their applications in bioimaging will be covered. Prospects and challenges associated with polymer-AuNPs-based bioimaging agents in preclinical and clinical investigations will be discussed.

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“…As a capable sono-sensitizer, Au NPs have been proven to act as nucleation sites for ultrasonic cavitation and decrease the cavitation threshold [ 31 ] Furthermore, the combination of gold with titania preserves electron-hole recombination by trapping the excited electron [ 24 ]. Also, AuNPs have been used in diverse investigations, consisting of chemotherapy [ 13 ], DNA biosensors [ 29 ], Photothermal Therapy (PTT) [ 32 ], and imaging [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

A Study of Sonodynamic Therapy of Melanoma C540 Cells in Vitro by Titania/Gold Nanoparticles

2023

J Biomed Phys Eng

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Background: Sonodynamic Therapy (SDT), a safe and non-invasive strategy in tumor therapy, is in development using novel sono-sensitizers, activated by low-intensity ultrasound radiation. SDT mainly progresses through Reactive Oxygen Species (ROS) generation followed by cell annihilation. Objective: The current study aimed to investigate the effect of ultrasound therapy with titania/gold nanoparticles (NPs) on melanoma cancer. Material and Methods: In this experimental study, Titania/gold NPs (TGNPs) were synthesized, and their activity was investigated in sonodynamic therapy of a melanoma cancer cell line (C540). SDT was performed at 1.0 W cm -2 and 1.0 MHz for one minute. Results: The synthesized NPs that comprised gold NPs of <10 nm into titania NPs of <20 nm showed great stability and cytocompatibility. While TGNPs were biocompatible, a remarkable rate of cell ablation was observed upon ultrasound irradiation due to ROS generation. Conclusion: The SDT using TGNPs can be introduced as an alternative and low-cost treatment method for melanoma malignancy.

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Fabrication of targeted gold nanoparticle as potential contrast agent in molecular CT imaging

Cited by 16 publications

References 26 publications

Chemical potential and biomedical activity of gold nanoparticles in cancer and drug delivery systems: an updat

Chemical potential and biomedical activity of gold nanoparticles in cancer and drug delivery systems: an updat

Gold Polymer Nanomaterials: A Promising Approach for Enhanced Biomolecular Imaging

A Study of Sonodynamic Therapy of Melanoma C540 Cells in Vitro by Titania/Gold Nanoparticles

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