Fabrication of Taste-Masked Donut-Shaped Tablets Via Fused Filament Fabrication 3D Printing Paired with Hot-Melt Extrusion Techniques

Wang, Honghe; Dumpa, Nagireddy; Bandari, Suresh; Dürig, Thomas; Repka, Michael A.

doi:10.1208/s12249-020-01783-0

Cited by 54 publications

(32 citation statements)

References 49 publications

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“…On the other hand, these tablets had low friability due to the high content of EE in their structure (more than 46%). Moreover, EE can be used as a taste masking agent, as already discussed in Section 3.1 , due to its ability to remain unchanged in the neutral pH of the mouth, protecting the drug from the patient’s taste buds, but releasing the active ingredient immediately it is in contact with the gastric medium [ 1 ].…”

Section: 3d Printingmentioning

confidence: 99%

“…The search for innovative technologies in the production of new medicines is constant and involves techniques that are able to improve the physicochemical and bioavailability characteristics of drugs and increase the patient’s acceptance, among others. In the last two decades, hot melt extrusion (HME) has been extensively used as a technique for manufacturing solid dosage forms [ 1 ], especially linked to three-dimensional (3D) printing [ 2 ]. More specifically, the fused deposition modelling (FDM) 3D printing technique, where the melt material is deposited layer-by-layer to form an object, has been closely related to the HME process.…”

Section: Introductionmentioning

confidence: 99%

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Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and their use has been boosted in some production processes, such as hot melt extrusion (HME) and fused deposition modelling 3D printing, among other 3D printing techniques. Therefore, this review covers the studies using Eudragit polymers in the development of drug delivery systems produced by HME and 3D printing techniques over the last 10 years. Eudragit E has been the most used among them, mostly to formulate immediate release systems or as a taste-masker agent. On the other hand, Eudragit RS and Eudragit L100-55 have mainly been used to produce controlled and delayed release systems, respectively. The use of Eudragit polymers in these processes has frequently been devoted to producing solid dispersions and/or to prepare filaments to be 3D printed in different dosage forms. In this review, we highlight the countless possibilities offered by Eudragit polymers in HME and 3D printing, whether alone or in blends, discussing their prominence in the development of innovative modified drug release systems.

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Section: 3d Printingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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“…Cellulosic polymers were used to taste-mask caffeine citrate via hot-melt extrusion with milling to pelletize using ethylcellulose and soluble polymers as pore formers [ 142 ]. Caffeine citrate was also extruded with HPC and both with and without Eudragit ® E into filaments used to 3D print toroidal tablets [ 143 ]. Sildenafil citrate was taste-masked by extrusion with ethylcellulose, with the addition of crystalline calcium carbonate to adjust the local pH to reduce API solubility in saliva [ 144 ].…”

Section: Applications Of Twin-screw Melt Granulationmentioning

confidence: 99%

Twin-Screw Melt Granulation for Oral Solid Pharmaceutical Products

2021

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This article highlights the advantages of pharmaceutical continuous melt granulation by twin-screw extrusion. The different melt granulation process options and excipients are described and compared, and a case is made for expanded use of twin-screw melt granulation since it is a flexible and continuous process. Methods for binder selection are profiled with a focus on rheology and physical stability impacts. For twin-screw melt granulation, the mechanism of granulation and process impact on granule properties are described. Pharmaceutical applications of melt granulation ranging from immediate release of soluble and insoluble APIs, taste-masking, and sustained release formulation are reviewed, demonstrating the range of possibilities afforded by twin-screw melt granulation.

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“…In the china dish, the calculated amount of Beeswax was melted. Blend of polymers, diluents followed by the active pharmaceutical ingredient are added geometrically in molten mass 6,7,8,9,10 .…”

Section: Preparation Of Venlafaxine Hcl Floatingmentioning

confidence: 99%

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2021

IJPSR

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Drugs that have a proximal absorption window can be improved by the Gastro Retentive Drug Delivery System which provides continuously releasing the drug for a prolonged period of time as controlled delivery before it reaches its absorption site, thus ensuring its optimal bioavailability. The intend of this current work is to formulate a gastro retentive floating tablet of Venlafaxine hydrochloride by hot-melt extrusion method. The buoyancy of tablet leftovers for 24 hours in the stomach and in a controlled way the drug was released. In the present work, by using the direct compression method, various formulations were made, in which HPMC K15M, Guar gum, and Xanthan gum were included as swelling polymers, sodium bicarbonate as gas generating agent, and MCC as diluent, talc, and magnesium stearate used as glidant &lubricant respectively. By the UV spectroscopic and IR spectroscopic interpretation, the characterization of the drug was recognized. The hardness, friability, uniformity of weight, drug-polymer interaction, in-vitro floating studies, Swelling Index & in-vitro drug release studies were evaluated for all the prepared floating formulations. It can be concluded from the results that floating lag time decreased as the concentration of the polymer increased and the percentage drug release was extended. The viscosity of the polymer also showed a directly proportional relationship with the swelling characteristics of the tablets.

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Fabrication of Taste-Masked Donut-Shaped Tablets Via Fused Filament Fabrication 3D Printing Paired with Hot-Melt Extrusion Techniques

Cited by 54 publications

References 49 publications

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Twin-Screw Melt Granulation for Oral Solid Pharmaceutical Products

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