Fabrication of Textile-Based Scaffolds Using Electrospun Nanofibers for Biomedical Applications

Ashok, Kiran; Babu, M.; Kavitha, G.; Jeyanthi, R.; Ladchumananandasivam, Rasiah; Silva, O. da; Manikandan, E.

doi:10.1007/12_2022_135

Cited by 4 publications

(2 citation statements)

References 249 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Combining them with natural biomaterials and integrating smart technologies, such as drug-eluting coatings or tissue-specific nanostructures, holds promise for developing nextgeneration biomaterials with enhanced functionality and biocompatibility [190].…”

Section: Synthetic Biomaterialsmentioning

confidence: 99%

The Long and Winding Road to Cardiac Regeneration

Sacco,

Castaldo,

Di Meglio

et al. 2023

Applied Sciences

View full text Add to dashboard Cite

Cardiac regeneration is a critical endeavor in the treatment of heart diseases, aimed at repairing and enhancing the structure and function of damaged myocardium. This review offers a comprehensive overview of current advancements and strategies in cardiac regeneration, with a specific focus on regenerative medicine and tissue engineering-based approaches. Stem cell-based therapies, which involve the utilization of adult stem cells and pluripotent stem cells hold immense potential for replenishing lost cardiomyocytes and facilitating cardiac tissue repair and regeneration. Tissue engineering also plays a prominent role employing synthetic or natural biomaterials, engineering cardiac patches and grafts with suitable properties, and fabricating upscale bioreactors to create functional constructs for cardiac recovery. These constructs can be transplanted into the heart to provide mechanical support and facilitate tissue healing. Additionally, the production of organoids and chips that accurately replicate the structure and function of the whole organ is an area of extensive research. Despite significant progress, several challenges persist in the field of cardiac regeneration. These include enhancing cell survival and engraftment, achieving proper vascularization, and ensuring the long-term functionality of engineered constructs. Overcoming these obstacles and offering effective therapies to restore cardiac function could improve the quality of life for individuals with heart diseases.

show abstract

Section: Synthetic Biomaterialsmentioning

confidence: 99%

The Long and Winding Road to Cardiac Regeneration

Sacco,

Castaldo,

Di Meglio

et al. 2023

Applied Sciences

View full text Add to dashboard Cite

show abstract

“…Topical antibiotics have usually been paired with wound dressing that helps maximize efficacy of antibacterial activities . Traditional wound dressing is made of woven or nonwoven gauze based on natural and synthetic fibers, providing contamination prevention, hemostasis control, moist maintenance, bacterial infection control, and promotion of wound healing. − With the development of nanotechnology, it demonstrated that molecules and cells have properties of high selectivity and sensitivity, and electrospun nanofibers have been used to create extracellular matrix at the structural and functional levels in which targeted growth factors can be delivered for different cell types to control bacterial infection and retain cellular structures and functions. − …”

Section: Introductionmentioning

confidence: 99%

Incorporation of Gentamicin-Encapsulated Poly(lactic-co-glycolic acid) Nanoparticles into Polyurethane/Poly(ethylene oxide) Nanofiber Scaffolds for Biomedical Applications

Sun,

Heacock,

Chen

et al. 2023

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

The development of wound-dressing materials has attracted significant research interests in recent years. With the advancement of nanofabrication, the application of nanoparticles (NPs) in drug delivery systems has become feasible. However, most existing work focuses on incorporation of metal, metal/semimetal oxide, or organic particles into nanofiber scaffolds. There has been a lack of work on the incorporation of drug-encapsulated polymeric particles into nanofiber scaffolds. In this study, gentamicin-encapsulated poly(lactic-co-glycolic acid) (PLGA) NPs were synthesized via a double emulsion solvent evaporation method. Electrospinning was used to incorporate gentamicinencapsulated PLGA NPs into nanofiber scaffolds. Atomic force microscopy (AFM), dynamic light scattering, scanning electron microscopy (SEM), ultraviolet−visible spectroscopy (UV−vis), and an agar diffusion method were utilized to characterize the morphologies, release profiles, and antibacterial activities of various gentamicin-loaded PLGA NP-incorporated nanofiber scaffolds. The results indicated that the PLGA NPs had a spherical morphology with an average diameter of 130 nm. Purification of PLGA NPs was essential to eliminate the residual poly(vinyl alcohol) (PVA) and to prevent particle agglomeration. The purified PLGA NPs were uniformly and individually incorporated into the polyurethane (PU)/ poly(ethenyl oxide) (PEO) or PEO-only nanofiber scaffolds but nearly none into the PU-only fiber scaffolds. PEO served as a continuous phase in the PU/PEO mixture, which significantly improved the compatibility of PLGA NPs and PU, resulting in a well-dispersed distribution of PLGA NPs in the monolithic nanofiber scaffolds. Excellent antibacterial properties against Escherichia coli were found in both PU/PEO and PEO nanofiber scaffolds. This study of incorporating gentamicin-encapsulated PLGA NPs into fiber scaffolds provides insights for achieving successful incorporation of drug-encapsulated polymeric NPs into fiber scaffolds. This offers a promising microfabrication technology for delivery of therapeutic molecules with controlled release for biomedical applications.

show abstract

Applications of green nano textile materials for environmental sustainability and functional performance: Past, present and future perspectives

Rahaman,

Khan

2024

Nano-Structures & Nano-Objects

View full text Add to dashboard Cite

Fabrication of Textile-Based Scaffolds Using Electrospun Nanofibers for Biomedical Applications

Cited by 4 publications

References 249 publications

The Long and Winding Road to Cardiac Regeneration

The Long and Winding Road to Cardiac Regeneration

Incorporation of Gentamicin-Encapsulated Poly(lactic-co-glycolic acid) Nanoparticles into Polyurethane/Poly(ethylene oxide) Nanofiber Scaffolds for Biomedical Applications

Applications of green nano textile materials for environmental sustainability and functional performance: Past, present and future perspectives

Contact Info

Product

Resources

About