Fabrication of the electrochemically reduced graphene oxide-bismuth nanoparticles composite and its analytical application for an anticancer drug gemcitabine

Tandel, Ranjita D.; Teradal, Nagappa L.; Satpati, Ashis Kumar; Seetharamappa, J.

doi:10.1016/j.cclet.2016.11.028

Cited by 18 publications

(10 citation statements)

References 57 publications

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“…Determination of glucose in the blood assumes importance in clinical diagnostics of diabetes mellitus. Various approaches have been reported to anchor metal nanoparticles on graphene based materials to enhance the electrochemical activity towards biomolecules sensing [30][31][32]. For example, Seetharamappa and coworkers fabricated a material, Bi nanoparticles embedded rGO for the sensitive determination of an anticancer drug, gemcitabine [30].…”

Section: Graphene Based Electrodesmentioning

confidence: 99%

“…Various approaches have been reported to anchor metal nanoparticles on graphene based materials to enhance the electrochemical activity towards biomolecules sensing [30][31][32]. For example, Seetharamappa and coworkers fabricated a material, Bi nanoparticles embedded rGO for the sensitive determination of an anticancer drug, gemcitabine [30]. In the system, Bi/rGO nanocomposite, prepared through an eco-friendly approach i.e electrochemical reduction of graphene oxide and Bi-salt solution simultaneously in the potential range of -1.7 to 0.6 V in phosphate buffer of pH 6 ( Figure 6b).…”

Section: Graphene Based Electrodesmentioning

confidence: 99%

“…In the system, Bi/rGO nanocomposite, prepared through an eco-friendly approach i.e electrochemical reduction of graphene oxide and Bi-salt solution simultaneously in the potential range of -1.7 to 0.6 V in phosphate buffer of pH 6 ( Figure 6b). Improved electrochemical response was noticed upon the incorporation of metallic Bi nanoparticles, as Bi nanoparticles are known for their electrocatalytic activities [30]. Similarly, Chen et al have developed Au nanoparticles embedded graphene, prepared through electrochemical approach, and was used for simultaneous and selective electrochemical determination of dihydroxybenzene isomers [31].…”

Section: Graphene Based Electrodesmentioning

confidence: 99%

“…(E)Cyclic voltammograms of 0.1 mM [Fe(CN)6] 3−/4− in 1 mM KNO3 at CrGO/GCE (a), HrGO/GCE (b), ErGO/GCE (c), GO/GCE (d), and bare GCE (e). Figures A-E reprinted with the permission from [25].Metal or metal oxide nanoparticle induced graphene based materials are being explored in order to catalyze the electrochemical responses of various biomolecules[29,30]. Specifically, Peng et al have developed an electrode material, CuO nanoparticles anchored S-doped graphene by microwave-assisted method(Figure 6a) and…”

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confidence: 99%

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Electrochemical Investigations of Biomolecules Using Carbon Nanotube and Graphene Based Modified Electrodes

Nl¹

2019

NNOA

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Carbon nanostructures, carbon nanotubes (CNTs) and reduced graphene oxide (rGO) have been used to modify the electrodes to decrease the over potential and improve the sensitivity. In this tutorial article, we focus on recent literature that describes how CNTs-and rGO-modified electrodes are being used for electrochemical investigations of several biologically important molecules or pharmaceutical drugs. Huge electroactive surface area and superior electron transfer properties make CNTs and rGO good candidates for electrode materials. Various electrochemical techniques viz., cyclic voltammetric, differential pulse voltammetric, stripping voltammetric, amperometric etc., have been used to explore detailed electrochemistry of biomolecules and to develop electroanalytical methods for their assay in pharmaceutical formulations and biological samples. Future challenges lie in the development of selective, sensitive, reproducible and simultaneous determination of biomolecules.

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Section: Graphene Based Electrodesmentioning

confidence: 99%

Section: Graphene Based Electrodesmentioning

confidence: 99%

Section: Graphene Based Electrodesmentioning

confidence: 99%

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confidence: 99%

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Electrochemical Investigations of Biomolecules Using Carbon Nanotube and Graphene Based Modified Electrodes

Nl¹

2019

NNOA

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“…Several analytical techniques have been used to evaluate gemcitabine in pharmaceutical products including HPLC [10,11], HPLC-MS [12], LC-MS/MS [13,14], UV spectrophotometric methods [15][16][17] and some electrochemical methods [18][19][20][21]. However, these techniques are generally complicated, time-consuming, expensive, and require relatively complex processes of specimen treatment.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and evaluation of potentiometric sensors of an anticancer drug (Gemcitabine)

et al. 2020

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Accurate, rapid and inexpensive determination of gemcitabine, an anticancer drug, is of high interest. This manuscript describes the use of potentiometric sensors as a basis for this work given their known attractive characteristics that meet our needs. Potentiometric sensors were comprised of carbon paste S1, coated wire S2 and PVC membrane S3, of gemcitabine (an anticancer drug) were fabricated, studied and evaluated. The calibration plots for these electrodes showed a Nernstian slope of 58.4±0.3, 59.5±0.3 and 58.3±0.3 mV per decade with the limit of detection: 6.50×10-5, 7.20×10-5 and 4.60×10-5 for sensors S1, S2 and S3, respectively. The electrodes have a short and stable response time of ~5 seconds and good reproducibility in a pH range of 2.5-9.5. The present sensors show distinct selectivity toward the drug ion in comparison to several inorganic ions, sugars, amino acids and some common drug excipients. Gemcitabine was determined successfully in ampoules and urine using these sensors by the calibration curve method.

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Electrochemically Reduced Graphene Oxide: A Smart Material for Electrochemical Sensing

Kaushik

Basu

2019

Handbook of Graphene

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Fabrication of the electrochemically reduced graphene oxide-bismuth nanoparticles composite and its analytical application for an anticancer drug gemcitabine

Cited by 18 publications

References 57 publications

Electrochemical Investigations of Biomolecules Using Carbon Nanotube and Graphene Based Modified Electrodes

Electrochemical Investigations of Biomolecules Using Carbon Nanotube and Graphene Based Modified Electrodes

Fabrication and evaluation of potentiometric sensors of an anticancer drug (Gemcitabine)

Electrochemically Reduced Graphene Oxide: A Smart Material for Electrochemical Sensing

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