Fabrication of thermoresponsive degradable hydrogel made by radical polymerization of 2-methylene-1,3-dioxepane: Unique thermal coacervation in hydrogel

Komatsu, Syuuhei; Asoh, Taka‐Aki; Ishihara, Ryo; Kikuchi, Akihiko

doi:10.1016/j.polymer.2019.121633

Cited by 26 publications

(27 citation statements)

References 32 publications

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“…The balance of hydrophilic (HEA and PEG) and hydrophobic (MDO) segments affects the expression of thermoresponsive properties. 13 , 15 , 16 An increase in the feed composition of MDO induced lower swelling ratios in all temperature ranges examined ( Figure S1 ).…”

Section: Resultsmentioning

confidence: 97%

“…2-Methylene-1,3-dioxepane (MDO) was prepared by a two-step reaction according to the previous reports. 13 − 16 FITC–fibrinogen was synthesized from fibrinogen and FITC in carbonate buffer (pH 8.5) for 20 h at 25 °C.…”

Section: Experimental Sectionmentioning

confidence: 99%

“…We recently reported the preparation and characterization of degradable and thermoresponsive hydrogels by the radical copolymerization of 2-methylene-1,3-dioxepane (MDO) and 2-hydroxyethyl acrylate (HEA). 13 The degradation of the prepared hydrogels could be controlled in terms of bulk degradation or surface degradation by the thermoresponsive swelling–deswelling property. Degraded HEA-based oligomers were soluble in water.…”

Section: Introductionmentioning

confidence: 99%

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Protein Removal from Hydrogels through Repetitive Surface Degradation

Kamiya

Komatsu

Kikuchi

2021

ACS Appl. Bio Mater.

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Suppression of protein adsorption is a necessary property for materials used in the living body. In this study, thermoresponsive and degradable hydrogels were prepared by the radical polymerization of 2-methylene-1,3-dioxepane, 2-hydroxyethyl acrylate (HEA), and poly(ethylene glycol) monomethacrylate (PEGMA). The prepared hydrogels re-exposed PEG-grafted chains to the interface through surface degradation, which was confirmed by the maintenance of the chemical composition of the hydrogel surfaces after hydrolysis. Notably, adsorbed proteins can be removed from the hydrogel surfaces through hydrogel surface degradation at least thrice.

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Section: Resultsmentioning

confidence: 97%

Section: Experimental Sectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protein Removal from Hydrogels through Repetitive Surface Degradation

Kamiya

Komatsu

Kikuchi

2021

ACS Appl. Bio Mater.

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“…[76]. This process can be conducted in several ways, both physical and chemical (Figure 4) [77]. Physical methods include imine bonding, motel-complexation, and disulfide bonds to create strong structures through chemical means.…”

Section: Physical Crosslinkingmentioning

confidence: 99%

Recent Progress in Biopolymer-Based Hydrogel Materials for Biomedical Applications

Mahmood

Patel

Hickson

et al. 2022

IJMS

126

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Hydrogels from biopolymers are readily synthesized, can possess various characteristics for different applications, and have been widely used in biomedicine to help with patient treatments and outcomes. Polysaccharides, polypeptides, and nucleic acids can be produced into hydrogels, each for unique purposes depending on their qualities. Examples of polypeptide hydrogels include collagen, gelatin, and elastin, and polysaccharide hydrogels include alginate, cellulose, and glycosaminoglycan. Many different theories have been formulated to research hydrogels, which include Flory-Rehner theory, Rubber Elasticity Theory, and the calculation of porosity and pore size. All these theories take into consideration enthalpy, entropy, and other thermodynamic variables so that the structure and pore sizes of hydrogels can be formulated. Hydrogels can be fabricated in a straightforward process using a homogeneous mixture of different chemicals, depending on the intended purpose of the gel. Different types of hydrogels exist which include pH-sensitive gels, thermogels, electro-sensitive gels, and light-sensitive gels and each has its unique biomedical applications including structural capabilities, regenerative repair, or drug delivery. Major biopolymer-based hydrogels used for cell delivery include encapsulated skeletal muscle cells, osteochondral muscle cells, and stem cells being delivered to desired locations for tissue regeneration. Some examples of hydrogels used for drug and biomolecule delivery include insulin encapsulated hydrogels and hydrogels that encompass cancer drugs for desired controlled release. This review summarizes these newly developed biopolymer-based hydrogel materials that have been mainly made since 2015 and have shown to work and present more avenues for advanced medical applications.

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“…For anti-cancer therapy, numerous types of polymeric hydrogels have been developed [ 15 , 16 , 17 , 18 ]. There are several advantages to using a hydrogel as a carrier for the delivery of anti-cancer drugs and hydrophobic PTT agents, such as a good biocompatibility, high stability, and controlled drug release [ 19 , 20 , 21 ]. Most trials on hydrogels for the treatment of cancer have investigated the injection of hydrogels into mice [ 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Attachable Hydrogel Containing Indocyanine Green for Selective Photothermal Therapy against Melanoma

Hwang

2020

Biomolecules

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Melanoma is the most lethal form of skin cancer because it spreads easily to other tissues, thereby decreasing the efficiency of its treatment via chemo-, radio-, and surgical therapies. We suggest the application of an attachable hydrogel for the treatment of melanoma whereby the size and amount of incorporated indocyanine green (ICG) for photothermal therapy (PTT) can be controlled. An attachable hydrogel (poly(acrylamide-co-diallyldimethylammonium chloride); PAD) that incorporates ICG as a near-infrared (NIR) absorber was fabricated using a biocompatible polymer. The temperature of PAD-ICG increases under 808 nm laser irradiation. The hydrogel protects the ICG against decomposition; consequently, PAD-ICG can be reused for PTT. The attachment of PAD-ICG to an area with melanoma in mice, with irradiation using a NIR laser, successfully eliminated melanoma. Thus, the data suggest that PAD-ICG is a smart material that could be used for selective target therapy against melanoma in humans.

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Fabrication of thermoresponsive degradable hydrogel made by radical polymerization of 2-methylene-1,3-dioxepane: Unique thermal coacervation in hydrogel

Cited by 26 publications

References 32 publications

Protein Removal from Hydrogels through Repetitive Surface Degradation

Protein Removal from Hydrogels through Repetitive Surface Degradation

Recent Progress in Biopolymer-Based Hydrogel Materials for Biomedical Applications

Attachable Hydrogel Containing Indocyanine Green for Selective Photothermal Therapy against Melanoma

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