Fabrication of versatile poly(xylitol sebacate)-co-poly(ethylene glycol) hydrogels through multifunctional crosslinkers and dynamic bonds for wound healing

Yeh, Ying-Yu; Lin, Yi-Yun; Wang, Ting-Teng; Yeh, Yu-Jia; Chiu, Ting-Hsiang; Wang, Reuben; Bai, Meng-Yi; Yeh, Yi-Cheun

doi:10.1016/j.actbio.2023.08.026

Cited by 7 publications

(2 citation statements)

References 82 publications

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“…The healing speeds of the gelatin-based hydrogels were all faster than the control group, as shown in Figure 6a,b, and the wound defects of the gelatin-based hydrogels scabbed within 7 days, faster than the control group. After 14 days, the wounds in the gelatin-based hydrogel groups were almost completely healed, similar to and even better than those in references [27,33,34]. As demonstrated in the H&E staining pictures in Figure 6c, there was less inflammatory cell infiltration in the gelatin-based hydrogels, agreeing with the in vitro experiments.…”

Section: Wound Closure Evaluation Of Hydrogelssupporting

confidence: 82%

“…The microstructures of the hydrogel samples, observed via scanning electron microscopy (SEM), are shown in Figure 3. Like the hydrogels from [26,27], the gelatin-based hydrogel samples all displayed an interconnected and well-proportioned macroporous network. This structure is similar to the extracellular matrix and is beneficial for wound healing [28,29].…”

Section: Synthesis and Physicochemical Characterization Of Hydrogelsmentioning

confidence: 95%

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Gelatin-Based Hydrogel Functionalized with Dopamine and Layered Double Hydroxide for Wound Healing

Zhang,

Wang

et al. 2024

Gels

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Hydrogels with adhesion properties and a wetted structure are promising alternatives to traditional wound dressing materials. The insufficiency of gelatin hydrogels in terms of their adhesive and mechanical strength limits their application in wound dressings. This work presents the design and preparation of a gelatin-based hydrogel functionalized with dopamine (DA) and layered double hydroxide (LDH). The combination of DA and LDH improves the hydrogel’s adhesion properties in terms of interfacial adhesion and inner cohesion. Hydrogels with 8% DA and 4% LDH attained the highest adhesion strength of 266.5 kPa, which increased to 295.5 and 343.3 kPa after hydrophobically modifying the gelatin with octanoyl and decanoyl aldehydes, respectively. The gelatin-based hydrogels also demonstrated a macroporous structure, excellent biocompatibility, and a good anti-inflammatory effect. The developed hydrogels accelerated wound healing in Sprague Dawley rat skin full-thickness wound models.

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Section: Wound Closure Evaluation Of Hydrogelssupporting

confidence: 82%

Section: Synthesis and Physicochemical Characterization Of Hydrogelsmentioning

confidence: 95%

Gelatin-Based Hydrogel Functionalized with Dopamine and Layered Double Hydroxide for Wound Healing

Zhang,

Wang

et al. 2024

Gels

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Electrospun Composite PLLA‐PPSB Nanofiber Nerve Conduits for Peripheral Nerve Defects Repair and Regeneration

Dai,

Lu,

et al. 2024

Adv Healthcare Materials

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Peripheral nerve injury (PNI) is a common clinical problem and regenerating peripheral nerve defects remains a significant challenge. Poly(polyol sebacate) (PPS) polymers have been developed as promising materials for biomedical applications due to their biodegradability, biocompatibility, elastomeric properties, and ease of production. However, the application of PPS‐based biomaterials in nerve tissue engineering, especially in PNI repair, is limited. In this study, we aimed to construct PPS‐based composite nanofibers poly(l‐lactic acid)‐poly(polycaprolactone triol‐co‐sebacic acid‐co‐N,N‐bis(2‐hydroxyethyl)‐2‐aminoethanesulfonic acid sodium salt) (PLLA‐PPSB) through electrospinning and assess their in vitro biocompatibility with Schwann cells (SCs) and in vivo repair capabilities for peripheral nerve defects. For the first time, the biocompatibility and bioactivity of PPS‐based nanomaterial were examined at the molecular, cellular, and animal levels for PNI repair. Electrospun PLLA‐PPSB nanofibers displayed favorable physicochemical properties and biocompatibility, providing an effective interface for the proliferation, glial expression, and adhesion of SCs in vitro. In vivo experiments using a 10‐mm rat sciatic nerve defect model showed that PLLA‐PPSB nanofiber nerve conduits enhanced myelin formation, axonal regeneration, angiogenesis, and functional recovery. Transcriptome analysis and biological validation indicated that PLLA‐PPSB nanofibers might promote SC proliferation by activating the PI3K/Akt signaling pathway. This suggests the promising potential of PLLA‐PPSB nanomaterial for PNI repair.This article is protected by copyright. All rights reserved

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Effects of blending poly (polyol sebacate) and poly (polyol adipate) bioelastomers for soft tissue engineering in biomedical applications

Norouznezhad,

Mir Mohamad Sadeghi

2024

J of Applied Polymer Sci

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In this article, the synthesis of four novel bioelastomers known as poly (xylitol sebacate) (PXS), poly (xylitol adipate) (PXA), poly (sorbitol sebacate) (PSS), and poly (sorbitol adipate) (PSA) was carried out through bulk polymerization, followed by their blending using the solution method. Six blends were prepared namely PXS25/PSS75, PXS50/PSS50, PXS75/PSS25, PXS50/PXA50, PSA50/PXA50, and PSS50/PSA50. After blending, a thermal curing process was applied to the samples. The intrinsic viscosity, density, Tg, hydrophilicity, degradation, wound healing, and mechanical properties of polymers and blends were measured to investigate the effects of blending. Analyzing hardness, modulus, stress at breakpoint, degradation, and hydrophilicity data showed that the mechanical properties of bioelastomers are adjustable by blending for tissue engineering. Furthermore, the scratch assay proved the biocompatibility of pure polymers and indicated that blending does not have a negative impact on this matter.

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Fabrication of versatile poly(xylitol sebacate)-co-poly(ethylene glycol) hydrogels through multifunctional crosslinkers and dynamic bonds for wound healing

Cited by 7 publications

References 82 publications

Gelatin-Based Hydrogel Functionalized with Dopamine and Layered Double Hydroxide for Wound Healing

Gelatin-Based Hydrogel Functionalized with Dopamine and Layered Double Hydroxide for Wound Healing

Electrospun Composite PLLA‐PPSB Nanofiber Nerve Conduits for Peripheral Nerve Defects Repair and Regeneration

Effects of blending poly (polyol sebacate) and poly (polyol adipate) bioelastomers for soft tissue engineering in biomedical applications

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