Fabrication, Property and Application of Calcium Alginate Fiber: A Review

Zhang, Xiaolin; Wang, Xinran; Fan, Wei; Liu, Yi; Wang, Qi; Weng, Lin

doi:10.3390/polym14153227

Cited by 64 publications

(26 citation statements)

References 114 publications

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“…High hygroscopicity. Alginate dressings are extremely hydrophilic and can be used for highly exuding wounds [ 170 ]. 2.…”

Section: Advanced Polymer Hydrogels For Dusmentioning

confidence: 99%

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

Wei

et al. 2023

Biomater Res

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Diabetic ulcers (DUs) are one of the most serious complications of diabetes mellitus. The application of a functional dressing is a crucial step in DU treatment and is associated with the patient's recovery and prognosis. However, traditional dressings with a simple structure and a single function cannot meet clinical requirements. Therefore, researchers have turned their attention to advanced polymer dressings and hydrogels to solve the therapeutic bottleneck of DU treatment. Hydrogels are a class of gels with a three-dimensional network structure that have good moisturizing properties and permeability and promote autolytic debridement and material exchange. Moreover, hydrogels mimic the natural environment of the extracellular matrix, providing suitable surroundings for cell proliferation. Thus, hydrogels with different mechanical strengths and biological properties have been extensively explored as DU dressing platforms. In this review, we define different types of hydrogels and elaborate the mechanisms by which they repair DUs. Moreover, we summarize the pathological process of DUs and review various additives used for their treatment. Finally, we examine the limitations and obstacles that exist in the development of the clinically relevant applications of these appealing technologies. Graphical Abstract This review defines different types of hydrogels and carefully elaborate the mechanisms by which they repair diabetic ulcers (DUs), summarizes the pathological process of DUs, and reviews various bioactivators used for their treatment.

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“…High hygroscopicity. Alginate dressings are extremely hydrophilic and can be used for highly exuding wounds [ 170 ]. 2.…”

Section: Advanced Polymer Hydrogels For Dusmentioning

confidence: 99%

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

Wei

et al. 2023

Biomater Res

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“…The ammability test of all the Alg-PET composite felts with different mass ratios and stacking structures were conducted according to the standard of the Pennsylvania Stuffed Toy Regulations § 47.317 24,25 . The lling material utilization in the toy or furniture burned at a rate of no more than 3 sec for 12 si on the surface.…”

Section: Flammability Testmentioning

confidence: 99%

Upcycling of polyester wastes blended bio-based alginate fiber to fire-safety composite applied in the construct field

Weng

Zhang

2023

Preprint

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A depleting fossil reserve and the troublesome recycling corresponding waste is worldwide problem. This work upcycled polyester waste fiber with intrinsic nonflammable bio-based alginate fiber via opening-combing-needle punching technique into a fire-proof building material to reduce waste disposal and carbon footprint. The composite was proved to generate minor amount of smoke and heat, and abundant nonflammable CO2 and H2O in the pyrolysis process.With very limited flammable H2, CO and C2H4, those can be completely diluted by the nonflammable gases. Furthermore, the credible flame-retardant mechanism of fuel-dilution effect was proposed, that was the final formed Ca-C residual chars cooperating with larger number of nonflammable gaseous volatile employed as a natural barrier to impede the heat, O2 and mass transfer, which can dramatically reduce the fire hazard. Taken together, this research recycled the waste chemical fiber into the outstanding fire-proofing composite applied in the construct field by a cost-effective and eco-friendly method.

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“…A recent review [ 4 ] surveys various manufacturing technologies for the production of calcium alginate fibers including freeze-drying [ 5 , 6 ], wet-spinning technology [ 7 , 8 , 9 ], an immersive centrifugal jet spinning technique [ 10 , 11 ], and microfluidic spinning technology [ 12 , 13 , 14 , 15 ]. Freeze-drying is, by itself, not a method of producing the fibers, but rather a post-fabrication technique to introduce porosity within alginate fibers during the freeze-drying stage once fibers are produced.…”

Section: Introductionmentioning

confidence: 99%

Dissolvable Calcium Alginate Microfibers Produced via Immersed Microfluidic Spinning

et al. 2023

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Fabrication of micro- and nanofibers are critical for a wide range of applications from microelectronics to biotechnology. Alginate microfibers with diameters of tens to hundreds of microns play an important role in tissue engineering and fibers of these diameters are impossible to fabricate via electrospinning and can only be produced via fluidic spinning. Typically, microfluidic spinning based on photopolymerization produces fibers that are not easily dissolvable, while fluidic spinning with chemical cross-linking employs complex setups of microfabricated chips or coaxial needles, aimed at precise control of the fiber diameter; however, fluidic spinning introduces significant cost and complexity to the microfluidic setup. We demonstrate immersed microfluidic spinning where a calcium alginate microfiber is produced via displacement of alginate solution through a single needle that is immersed in a cross-linking bath of calcium chloride solution. The resulting diameter of the fiber is characterized and the fiber diameter and topology of the deposited fiber is related to the concentration of the alginate solution (2 wt %, 4 wt %, and 6 wt %), needle gauge (30 g, 25 g, and 20 g), and the volumetric flow rate of the alginate solution (1 mL/min, 2 mL/min, and 2.7 mL/min). The resulting fiber diameter is smaller than the internal diameter of the needle and this dependence is explained by the continuity of the flow and increased rate of fall of the liquid jet upon its issuing from the needle. The fiber diameter (demonstrated diameter of fibers range from 100 microns to 1 mm) depends weakly on the volumetric flow rate and depends strongly on the needle diameter. It also seems that for a smaller needle size, a greater concentration of alginate results in smaller diameter fibers and that this trend is not evident as the needle diameter is increased. In terms of topology of the deposited fiber, the higher wt % alginate fiber produces larger loops, while smaller wt % alginate solution yields a denser topology of the overlaid fiber loops. These fibers can be dissolved in DMEM/EDTA/DSC solution in 20–30 min (depending on the fiber diameter), leaving behind the hollow channels in the hydrogel matrix. We believe that the demonstrated simple setup of the immersed microfluidic spinning of the calcium alginate microfibers will be useful for creating tissue constructs, including the vascularized tissue implants.

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Fabrication, Property and Application of Calcium Alginate Fiber: A Review

Cited by 64 publications

References 114 publications

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications

Upcycling of polyester wastes blended bio-based alginate fiber to fire-safety composite applied in the construct field

Dissolvable Calcium Alginate Microfibers Produced via Immersed Microfluidic Spinning

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