Face detection in UAV imagery requires high accuracy and low execution time for real-time mission-critical operations in public safety, emergency management, disaster relief and other applications. This study presents UWS-YOLO, a new convolutional neural network (CNN)-based machine learning algorithm designed to address these demanding requirements. UWS-YOLO’s key strengths lie in its exceptional speed, remarkable accuracy and ability to handle complex UAV operations. This algorithm presents a balanced and portable solution for real-time face detection in UAV applications. Evaluation and comparison with the state-of-the-art algorithms using standard and UAV-specific datasets demonstrate UWS-YOLO’s superiority. It achieves 59.29% of accuracy compared with 27.43% in a state-of-the-art solution RetinaFace and 46.59% with YOLOv7. Additionally, UWS-YOLO operates at 11 milliseconds, which is 345% faster than RetinaFace and 373% than YOLOv7.