Visual speech animation (VSA) has many potential applications in humancomputer interaction, assisted language learning, entertainments, and other areas. But it is one of the most challenging tasks in human motion animation because of the complex mechanisms of speech production and facial motion. This chapter surveys the basic principles, state-of-the-art technologies, and featured applications in this area. Specifically, after introducing the basic concepts and the building blocks of a typical VSA system, we showcase a state-of-the-art approach based on the deep bidirectional long short-term memory (DBLSM) recurrent neural networks (RNN) for audio-to-visual mapping, which aims to create a video-realistic talking head. Finally, the Engkoo project from Microsoft is highlighted as a practical application of visual speech animation in language learning.