Facial control of gas-phase enantioselectivity of strapped tetra-amide macrocycles

Fraschetti, Caterina; Pierini, Marco; Villani, Claudio; Gasparrini, Francesco; Mortera, Stefano Levi; Filippi, Antonello; Speranza, Maurizio

doi:10.1007/s12210-011-0131-7

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Amino Ester and Amino Acids1

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Cited by 2 publications

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“…33,56 Amino acids, amino acid esters, and amino alcohols Ion/molecule reactions: host compounds can be tetra-amide macrocycles or resorcinarene. 57,58 Pramipexole, propranolol, tamslosin, tenofovir, tropine, valacyclovir, and zolmitriptan Chiral recognition ratio method: alpha/beta/gama-CD and [Cu(piodo-Phe/ diiodo-Tyr)] were suitable ligands. 59,60 Pentose isomers, hexose isomers, and amino acid Fixed ligand kinetic method: unique fixed ligand could be created, like guanosine monophosphate.…”

Section: Amino Ester and Amino Acidsmentioning

confidence: 99%

Analysis of stereoisomers of chiral drug by mass spectrometry

2018

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Chiral molecules are of great importance in the life science since individual enantiomers may differ in biological activity, mechanism, and toxicity, making it necessary to explore efficient chiral analysis methods. Chromatography approaches are often used to differentiate enantiomers while mass spectrometry (MS) was thought to be blind in chiral analysis. With the development of MS technique, it began to play a more and more crucial part in chiral observation. In this review, we will give a detailed introduction of the analysis methods related to MS for chiral drugs, including its mechanism, applications, and future development.

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