Facial Emotion Processing in Schizophrenia: A Meta-analysis of Functional Neuroimaging Data

Li, Huijie; Chan, Raymond C. K.; McAlonan, Gráinne; Gong, Qiyong

doi:10.1093/schbul/sbn190

Cited by 332 publications

(248 citation statements)

References 71 publications

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“…However, there was one main neural activation difference that distinguished the impaired TBI group from the HC group. Our TBI-I group had significantly less activation in the right fusiform gyrus compared to HCs during the facial affect recognition task, consistent with our a priori hypotheses and prior literature findings in autism and schizophrenia (Edwards et al 2002;Li et al 2010). Additionally, there was a trend suggesting that right fusiform gyrus activation for the TBI-N group was intermediate to that in the HC and TBI-I groups.…”

Section: Discussionsupporting

confidence: 88%

“…Importantly, this groundwork enables functional and meaningful interpretations to be made from neuroimaging studies that aim to understand facial affect recognition deficits in populations with impairments to these areas. For instance, numerous neuroimaging studies have already investigated the neurobiological mechanisms underlying facial affect recognition impairments in people with autism and schizophrenia (Harms et al 2010;Li et al 2010). The most consistent finding across these studies has been reduced activation in the amygdala and fusiform gyrus during facial affect recognition tasks relative to controls (Harms et al 2010;Li et al 2010).…”

Section: Conceptual Understandingmentioning

confidence: 99%

“…For instance, numerous neuroimaging studies have already investigated the neurobiological mechanisms underlying facial affect recognition impairments in people with autism and schizophrenia (Harms et al 2010;Li et al 2010). The most consistent finding across these studies has been reduced activation in the amygdala and fusiform gyrus during facial affect recognition tasks relative to controls (Harms et al 2010;Li et al 2010). This suggests that deficient affect recognition in people with autism and schizophrenia may be the result of problems with perceptual processing of facial expressions and/or emotional experience and replication.…”

Section: Conceptual Understandingmentioning

confidence: 99%

See 2 more Smart Citations

Neurobiological mechanisms associated with facial affect recognition deficits after traumatic brain injury

Neumann

McDonald

West

et al. 2015

Brain Imaging and Behavior

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Section: Discussionsupporting

confidence: 88%

Section: Conceptual Understandingmentioning

confidence: 99%

Section: Conceptual Understandingmentioning

confidence: 99%

See 1 more Smart Citation

Neurobiological mechanisms associated with facial affect recognition deficits after traumatic brain injury

Neumann

McDonald

West

et al. 2015

Brain Imaging and Behavior

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“…Nonetheless, an acceptable proxy may be to survey existing neuroimaging studies of emotion perception in psychosis [15,27,28], and interpret their findings within the context of attentional and interpretative biases. Facilitating this interpretation is a model of aberrant emotion perception in schizophrenia [29].…”

Section: Introductionmentioning

confidence: 99%

Psychobiology of threat appraisal in the context of psychotic experiences: A selective review

2015

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A key factor in the transition to psychosis is the appraisal of anomalous experiences as threatening.Cognitive models of psychosis have identified attentional and interpretative biases underlying threatbased appraisals. While much research has been conducted into these biases within the clinical and cognitive literature, little examination has occurred at the neural level. However, neurobiological research in social cognition employing threatening stimuli mirror cognitive accounts of maladaptive appraisal in psychosis. This review attempted to integrate neuroimaging data regarding social cognition in psychosis with the concepts of attentional and interpretative threat biases. Systematic review methodology was used to identify relevant articles from Medline, PsycINFO and EMBASE, and PubMed databases. The selective review showed that attentional and interpretative threat biases relate to abnormal activation of a range of subcortical and prefrontal structures, including the amygdala, insula, hippocampus, anterior cingulate, and prefrontal cortex, as well as disrupted connectivity between these regions, when processing threatening and neutral or ambiguous stimuli.Notably, neural findings regarding the misattribution of threat to neutral or ambiguous stimuli presented a more consistent picture. Overall, however, the findings for any specific emotion were mixed, both in terms of the specific brain areas involved and the direction of effects (increased/decreased activity), possibly owing to confounds including small sample sizes, varying experimental paradigms, medication, and heterogeneous, in some cases poorly characterised, patient groups. Further neuroimaging research examining these biases by employing experimentally-induced anomalous perceptual experiences and well-characterised large samples is needed for greater aetiological specificity.

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“…Reduced angular gyrus activity in schizophrenia has been observed during facial emotion discrimination (Reske et al., 2009; Streit et al., 2001) or social cognition (Thakkar, Peterman, & Park, 2014). Patients with schizophrenia have also shown neural deficits in the fusiform gyrus during emotional face processing (Gur et al., 2002; Li, Chan, McAlonan, & Gong, 2010; Wolf et al., 2015). Consistent with these studies, we observed reduced angular and fusiform activity in patients induced by pictures which included human faces in various social situations.…”

Section: Discussionmentioning

confidence: 99%

Involvement of amygdala–prefrontal dysfunction in the influence of negative emotion on the resolution of cognitive conflict in patients with schizophrenia

et al. 2018

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IntroductionPatients with schizophrenia often have impaired cognition and abnormal conflict control. Conflict control is influenced by the emotional values of stimuli. This study investigated the neural basis of negative emotion interference with conflict control in schizophrenia.MethodsSeventeen patients with schizophrenia and 20 healthy controls underwent functional magnetic resonance imaging while performing the emotional Simon task, in which positive or negative emotional pictures were located in congruent or incongruent positions. Analysis was focused on identifying brain regions with the significant interaction among group, emotion, and conflict in whole brain voxel‐wise analysis, and abnormality in their functional connectivity in the patient group.ResultsThe regions showing the targeted interaction was the right amygdala, which exhibited significantly reduced activity in the negative congruent (t = −2.168, p = 0.036) and negative incongruent (t = −3.273, p = 0.002) conditions in patients versus controls. The right amygdala also showed significantly lower connectivity with the right dorsolateral prefrontal cortex in the cognitive and emotional loading contrast (negative incongruent—positive congruent) in patients versus controls (t = −5.154, p < 0.01), but not in the cognitive‐only or emotional‐only loading contrast.ConclusionsThese results suggest that negative emotion interferes with cognitive conflict resolution in patients with schizophrenia due to amygdala–dorsolateral prefrontal cortex disconnection. Based on these findings, interventions targeting conflict control under negative emotional influence may promote cognitive rehabilitation in patients with schizophrenia.

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Facial Emotion Processing in Schizophrenia: A Meta-analysis of Functional Neuroimaging Data

Abstract: A marked underrecruitment of the amygdala, accompanied by a substantial limitation in activation throughout a ventral temporal-basal ganglia-prefrontal cortex "social brain" system may be central to the difficulties patients experience when processing facial emotion.

Cited by 332 publications

References 71 publications

Neurobiological mechanisms associated with facial affect recognition deficits after traumatic brain injury

Neurobiological mechanisms associated with facial affect recognition deficits after traumatic brain injury

Psychobiology of threat appraisal in the context of psychotic experiences: A selective review

Involvement of amygdala–prefrontal dysfunction in the influence of negative emotion on the resolution of cognitive conflict in patients with schizophrenia

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