Facial emotion recognition and alexithymia in Chinese male patients with deficit schizophrenia

Tang, Xiao Wei; Yu, Miao; Duan, Wei; Zhang, Xiang Rong; Sha, Wei; Wang, Xiang; Zhang, Xiao Bin

doi:10.1016/j.psychres.2016.09.055

Cited by 24 publications

(13 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Deficit schizophrenia (DS), proposed by Carpenter et al (1988), characterizes patients with primary and permanent negative symptoms including restricted affect, diminished emotional range, poverty of speech, curbing of interests, diminished sense of purpose and diminished social drive (Carpenter et al, 1988; Kirkpatrick et al, 1989, 2001). Increasing evidence demonstrates discrepant factors between DS and non-deficit schizophrenia (NDS) in clinical symptoms, disease course, genetic variation (Hong et al, 2005; Wonodi et al, 2006; Bakker et al, 2007; Rethelyi et al, 2010), neuroimaging changes (Lahti et al, 2001; Galderisi et al, 2008; Voineskos et al, 2013; Lei et al, 2015) and neuropsychology (Cohen et al, 2007; Yu et al, 2015; Tang et al, 2016), suggesting that DS might be a homogeneous disease entity with a unique pathogenesis. The research on DS might help to understand the etiology of negative symptoms and prediction biomarkers for the long-term prognosis of patients with schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

DNA Methylation and Gene Expression of Matrix Metalloproteinase 9 Gene in Deficit and Non-deficit Schizophrenia

Gao

Tang

et al. 2018

Front. Genet.

Self Cite

View full text Add to dashboard Cite

The biological pathology of deficit schizophrenia (DS) remains unclear. Matrix metalloproteinase 9 (MMP9) might be associated with neural plasticity and glutamate regulation, involved in schizophrenia pathogenesis. This study explores gene expression and DNA methylation of MMP9 in peripheral blood mononuclear cells (PBMCs) and their relationship with clinical symptoms in DS and non-deficit schizophrenia (NDS). Pyrosequencing was used to determine DNA methylation at CpG sites in exon 4 and exon 5 of MMP9 in 51 DS patients, 53 NDS patients and 50 healthy subjects (HC). RT-qPCR was used to detect MMP9 expression. Clinical symptoms were assessed by BPRS, SANS and SAPS scales. MMP9 expression in PBMCs was significantly higher in DS than NDS and HC subjects. Compared to NDS patients, DS patients had significantly lower DNA methylation at individual CpG sites in exon 4 and exon 5 of MMP9. Correlation analysis showed that DNA methylation in exon 4 was negatively correlated with gene expression in DS group. Positive correlation was found between MMP9 expression and negative symptoms in total schizophrenic patients. The social amotivation factor of SANS and negative syndrome of BPRS was negatively correlated with DNA methylation of CpG5-1 in DS patients but not in NDS patients. DS patients showed a specific abnormality of peripheral MMP9 expression and DNA methylation, indicating a pathological mechanism underlying DS as a specific subgroup of schizophrenia.

show abstract

Section: Introductionmentioning

confidence: 99%

DNA Methylation and Gene Expression of Matrix Metalloproteinase 9 Gene in Deficit and Non-deficit Schizophrenia

Gao

Tang

et al. 2018

Front. Genet.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Alexithymia is broadly characterized as a range of interrelated difficulties to identify feelings and distinguish between feelings and bodily sensations of emotional arousal as well as a deficit in the ability to consciously experience, identify, and express emotions (Fogley et al., 2014 ), and focuses a specific impediment on awareness and expression of one's own emotions (Tang et al., 2016 ). Several authors have reported that alexithymia may be a vulnerability factor in the development of SCZ, but knowledge concerning this underpinning of deficits in emotion self‐awareness in SCZ remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Exploring the link between cognitive deficit, self‐esteem, alexithymia, and depressive symptom of schizophrenia

Zhang

Xia

et al. 2022

Brain and Behavior

View full text Add to dashboard Cite

Objective: To the best of our knowledge, studies have been rarely conducted to assess the correlation between cognitive deficit, self-esteem, and alexithymia in the depressive symptoms of schizophrenia (SCZ). Therefore, this study aims to explore the risk factors associated with impairment of cognitive function, alexithymia, and self-esteem among a representative sample of first-episode schizophrenic patients. Method:We recruited 107 first-episode schizophrenic patients (48.6% male, 51.4% female, 36.94 ± 10.73 years) into the research group, according to the Diagnostic and Statistical Manual of Mental Disorders (5th edition). A total of 45 healthy people (51.1% male, 48.9% female, 32.47 ± 10.94 years) were enlisted in the healthy control group. Psychotic symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS). Cognitive functions were estimated using the Montreal Cognitive Assessment Scale (MoCA). The feelings of respect and self-acceptance were tested using the Rosenberg Self-Esteem Scale (RSES). Emotion of identifying and describing were measured by self-report scale of Toronto Alexithymia Scale-20 (TAS-20).Results: Overall cognitive impairment and alexithymia were found more serious in the patients of SCZ than the healthy group (p < .001, respectively). The patients of SCZ have higher self-esteem than the healthy group (p = .013). Total score of MoCA, ability of visual space and executive function, and delayed recall were explored had negatively correlation with alexithymia (r = −.319, p = .001; r = −.248, p = .010; r = −0.263, p = .006). Total score of RSES and depressive symptoms of PANSS had a positive correlation with alexithymia (r = .394, p = .001; r = .208, p = .032). Stepwise regression analyses have shown a positive relationship between difficulty describing feelings and depression subscale of PANSS (β = .188, t = −2.007, p = .047) while a negative relationship between externally oriented thinking and depression subscale of PANSS (β = −.244, t = −2.603, p = .011). A positive link correlation also was found between the total scores of TAS and RSES (β = .372, t = 4.144, p = .001). A negative relevanceThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

“…Recent studies have identified a relationship between various symptoms of schizophrenia and alexithymia (the inability to identify the meaning and experience of emotion words) (Todarello et al, 2005; Fogley et al, 2014; Ospina et al, 2019) as well as with impaired facial emotion recognition (Tang et al, 2016). Yet, to the best of our knowledge studies examining facial emotion recognition in schizophrenia have rarely assessed the semantic understanding of emotion words prior to facial affect testing (Carra et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Impaired facial emotion perception of briefly presented double masked stimuli in violent offenders with schizophrenia spectrum disorders

Högman

Kristiansson

Fischer

et al. 2020

Schizophrenia Research: Cognition

View full text Add to dashboard Cite

Social interactions require decoding of subtle rapidly changing emotional cues in others to facilitate socially appropriate behaviour. It is possible that impairments in the ability to detect and decode these signals may increase the risk for aggression. Therefore, we examined violent offenders with schizophrenia spectrum disorders (SSD) and compared these with healthy controls on a computerized paradigm of briefly presented double masked faces exhibiting 7 basic emotions. Our hypotheses were that impaired semantic understanding of emotion words and low cognitive ability would yield lowest emotion recognition. SSD exhibited lower accuracy of emotion perception than controls (46.1% compared with 64.5%, p = 0.026), even when considering the unbiased hit rate (22.4% compared with 43%, Z = 2.62, p < 0.01). Raw data showed uncommon but significant misclassifications of fear as sad, disgust as sad, sad as happy and angry as surprise. Once guessing and presentation frequencies were considered, only overall accuracy differed between SSD and healthy controls. There were significant correlations between cognitive ability, antipsychotic dose, speed and emotion accuracy in the SSD group. In conclusion, that there were no specific emotion biases in the SSD group compared to healthy controls, but particular individuals may have greater impairments in facial emotion perception, being influenced by intellectual ability, psychomotor speed and medication dosages, rather than specifically emotion word understanding. This implies that both state and trait factors influence emotion perception in the aggressive SSD group and may reveal one source of potential misunderstanding of social situations which may lead to boundary violations and aggression.

show abstract

Facial emotion recognition and alexithymia in Chinese male patients with deficit schizophrenia

Cited by 24 publications

References 57 publications

DNA Methylation and Gene Expression of Matrix Metalloproteinase 9 Gene in Deficit and Non-deficit Schizophrenia

DNA Methylation and Gene Expression of Matrix Metalloproteinase 9 Gene in Deficit and Non-deficit Schizophrenia

Exploring the link between cognitive deficit, self‐esteem, alexithymia, and depressive symptom of schizophrenia

Impaired facial emotion perception of briefly presented double masked stimuli in violent offenders with schizophrenia spectrum disorders

Contact Info

Product

Resources

About