Facial emotion recognition in schizophrenia: An exploratory study on the role of comorbid alcohol and substance use disorders and <scp>COMT V</scp>al158<scp>M</scp>et

Carrà, Giuseppe; Nicolini, Gabriella; Lax, Annamaria; Bartoli, Francesco; Castellano, F.; Chiorazzi, A; Gamba, Giulia; Bava, Mattia; Crocamo, Cristina; Papagno, Costanza

doi:10.1002/hup.2630

Cited by 9 publications

(5 citation statements)

References 34 publications

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“…Detection of facial emotions is the area of emotional behaviour that is best studied with respect to COMT genotype, although a variety of different experimental approaches have been employed. Our findings agree with most earlier studies showing no overall effect of COMT genotype on facial emotion detection ( Carrà et al, 2017 ; Defrancesco et al, 2011 ; Kempton et al, 2009 ; Soeiro-de-Souza et al, 2012 ; Tamm et al, 2016 ). We cannot rule out more subtle effects of COMT on detection of specific types of emotional information.…”

Section: Discussionsupporting

confidence: 93%

“…Thus, while in some mouse models, lower COMT activity is associated with increased anxiety-like behaviours (Gogos et al, 1998;Papaleo et al, 2008), this is not seen for all COMT models (Barkus et al, 2016). Findings in human volunteers are also inconsistent: while some studies report exaggerated responses to negative stimuli and greater negative biases in processing emotional stimuli associated with the Met 158 , compared with the Val 158 , allele (Gohier et al, 2014;Gong et al, 2013;Montag et al, 2008), others have reported the opposite pattern (Weiss et al, 2007) or have found no genotype differences in emotional processing (Carrà et al, 2017;Defrancesco et al, 2011;Kempton et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Catechol-O-methyltransferase activity does not influence emotional processing in men

et al. 2022

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Background: Catechol-O-methyltransferase (COMT) regulates cortical dopaminergic transmission and prefrontal-dependent cognitive function. However, its role in other cognitive processes, including emotional processing, is relatively unexplored. We therefore investigated the separate and interactive influences of COMT inhibition and Val158Met (rs4680) genotype on performance on an emotional test battery. Methods: We recruited 74 healthy men homozygous for the functional COMT Val158Met polymorphism. Volunteers were administered either a single 200 mg dose of the brain-penetrant COMT inhibitor tolcapone or placebo in a double-blind, randomised manner. Emotional processing was assessed using the emotional test battery, and mood was rated using visual analogue scales and the Profile of Mood States (POMS) questionnaire across the test day. Results: There were no main or interactive effects of Val158Met genotype or tolcapone on any of the emotional processing measures or mood ratings. Conclusions: Our findings suggest that, at least in healthy adult men, COMT has little or no effect on emotional processing or mood. These findings contrast with several neuroimaging studies that suggest that COMT modulates neural activity during emotional processing. Thus, further studies are required to understand how COMT impacts on the relationship between behavioural output and neural activity during emotional processing. Nevertheless, our data suggest that novel COMT inhibitors under development for treating cognitive dysfunction are unlikely to have acute off target effects on emotional behaviours.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Catechol-O-methyltransferase activity does not influence emotional processing in men

et al. 2022

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“…201), and in psychophysiological investigations (202). Deficits can be apparent in patients with multiple sclerosis (203), frontotemporal dementia (204–206), schizophrenia (207–210), ASD [Refs. (150, 151, 211) and forensic: Ref.…”

Section: Resultsmentioning

confidence: 99%

What Do You Have in Mind? Measures to Assess Mental State Reasoning in Neuropsychiatric Populations

Eddy

2019

Front. Psychiatry

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Social interaction is closely associated with both functional capacity and well-being. Previous research has not only revealed evidence of social dysfunction in individuals with a wide range of psychiatric and neurological disorders but also generated an abundance of potential measures for assessing social cognition. This review explores the most popular measures used within neuropsychiatric populations to investigate the ability to recognize or reason about the mental states of others. Measures are also critically analyzed in terms of strengths and limitations to aid task selection in future clinical studies. The most frequently applied assessment tools use verbal, visual or audiovisual forms of presentation and assess recognition of mental states from facial features, self-rated empathy, the understanding of other’s cognitive mental states such as beliefs and intentions, or the ability to combine knowledge of other’s thoughts and emotions in order to understand subtle communications or socially inappropriate behavior. Key weaknesses of previous research include limited investigation of relationships with clinical symptoms, and underutilization of measures of everyday social functioning that offer a useful counterpart to traditional “lab” tasks. Future studies should aim to carefully select measures not only based on the range of skills to be assessed but also taking into account potential difficulties with interpretation and the need to gain insight into the application of social cognitive skills as well as ability per se . Some of the best measures include those with well-matched control trials (e.g., Yoni Task) or those that restrict the influence of verbal deficits (e.g., intentions comic strip task), elicit spontaneous mentalizing (e.g., Animations Task), and possess greater ecological validity (e.g., Movie for the Assessment of Social Cognition). Social cognitive research within psychiatric populations will be further enhanced through the development of more closely matched control tasks, and the exploration of relationships between task performance, medication, strategy use, and broader emotional and motor functions.

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“…Secondly, patients enrolled in present study were treated with different antipsychotics for a long-term period, which could affect cognitive function in chronic patients with schizophrenia. Thirdly, we just examined a single genetic polymorphism effect on cognitive impairments of patients with schizophrenia, and other polymorphisms and genes interaction should be concerned [42]. Last but not the least, the RBANS has five domains including immediate memory, attention, language, visuospatial/ constructional, and delayed memory.…”

Section: Discussionmentioning

confidence: 99%

FOXP2 contributes to the cognitive impairment in chronic patients with schizophrenia

Lang

Zhang

Song

et al. 2019

Aging

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The forkhead-box P2 (FOXP2), involving in language and memory function, has been identified as susceptibility to schizophrenia. However, no study examined the role of FOXP2 on cognitive impairment in schizophrenia. Total 1106 inpatients with schizophrenia and 404 controls were recruited and genotyped. Among them, 867 patients and 402 controls were assessed through the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). SHEsis software was used to investigate the association of FOXP2 rs10447760 with schizophrenia, followed by logistic regression. The model of covariance (ANCOVA) and multivariate analysis were conducted to investigate the effect of FOXP2 rs10447760 on cognitive impairment in schizophrenia. No differences in the genotypic and allelic frequencies of the FOXP2 rs10447760 were found between patients and controls (both p> 0.05). Except for the visuospatial/constructional score (p > 0.05), other five RBANS scores were lower in patients compared to controls (all p < 0.0001). Interestingly, we found immediate memory score was lower in patients carrying genotype CT compared to genotype CC (F=5.19, p=0.02), adjusting for confounding data. Our study suggested that FOXP2 rs10447760 has no effect on the susceptibility to schizophrenia, while it may be associated with its cognitive impairment, especially immediate memory in chronic schizophrenia.

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Facial emotion recognition in schizophrenia: An exploratory study on the role of comorbid alcohol and substance use disorders and COMT Val158Met

Cited by 9 publications

References 34 publications

Catechol-O-methyltransferase activity does not influence emotional processing in men

Catechol-O-methyltransferase activity does not influence emotional processing in men

What Do You Have in Mind? Measures to Assess Mental State Reasoning in Neuropsychiatric Populations

FOXP2 contributes to the cognitive impairment in chronic patients with schizophrenia

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