Facial nerve palsy and anti-Ku autoantibodies

Sutter, Raoul; Mengiardi, Bernard; Benz, David; Heijnen, Ingmar; Kappos, Ludwig; Winkler, David T.

doi:10.1007/s00415-011-6166-y

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…[13,14,25,33] On the contrary, trigeminal neuralgia and autoimmune thyroid disease were not seen in anti-Ku-positive subjects, contrary to what has been observed with anti-Ku in a few case reports and series. [22,42,56–58] …”

Section: Discussionmentioning

confidence: 99%

Single-specificity anti-Ku antibodies in an international cohort of 2140 systemic sclerosis subjects

Hudson

Troyanov

et al. 2016

Medicine

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Section: Discussionmentioning

confidence: 99%

Single-specificity anti-Ku antibodies in an international cohort of 2140 systemic sclerosis subjects

Hudson

Troyanov

et al. 2016

Medicine

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“…It is noteworthy that a significant portion of studies published over the last decades were case reports [30][31][32] in which anti-Ku antibodies were associated with facial nerve palsy, 31 camptocormia 32 and hepatitis C virus-related hepatocellular carcinoma. 33 A recent study found different clinical associations of autoantibodies to the two Ku protein subunits.…”

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confidence: 99%

Clinical and serological associations of autoantibodies to the Ku70/Ku80 heterodimer determined by a novel chemiluminescent immunoassay

Mähler

Swart²,

et al. 2016

Lupus

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Background: Autoantibodies targeting Ku, an abundant nuclear protein with DNA helicase activity, have been reported in patients with systemic autoimmune rheumatic diseases. Little is known about the clinical associations of anti-Ku antibodies, especially when novel diagnostic technologies are used. The objective of the present study was to analyse the prevalence of antiKu antibodies in different medical conditions using a novel chemiluminescent immunoassay. Patients and methods: Serum samples from adult patients with systemic lupus erythematosus (SLE, n¼305), systemic sclerosis (SSc, n¼70) and autoimmune myositis patients (AIM, n¼109) were the primary focus of the study. Results were compared with disease controls (rheumatoid arthritis, RA, n¼30; infectious diseases, n¼17) and healthy individuals (n¼167). In addition, samples submitted for routine autoantibody testing from patients referred to a rheumatology clinic (n¼1078) were studied. All samples were tested for anti-Ku antibodies by QUANTA Flash Ku chemiluminescent immunoassay (research use only, Inova Diagnostics, San Diego, USA) using full length recombinant human Ku. SLE patient samples were also tested for other autoantibodies. Clinical data of anti-Ku antibody positive patients (high titres) were obtained by retrospective chart review. Results and findings: In the disease cohorts, 30/305 (9.8%) SLE, 3/70 (4.3%) systemic sclerosis and 4/109 (3.7%) autoimmune myositis (AIM) patients were positive, respectively. The four positive AIM patients had an overlap myositis syndrome that included two patients with SLE. The three systemic sclerosis (SSc) positive samples had diagnoses of SSc/SLE overlap, diffuse cutaneous SSc, and early edematous phase SSc. In the control cohorts, 2/170 (1.2%) healthy individuals (all low titre), 0/30 (0.0%) (RA) and 0/17 (0.0%) infectious disease patients were positive. The area under the curve values were: 0.75 for SLE vs. controls, 0.68 for SSc vs. controls and 0.37 for AIM vs. controls. In the rheumatology clinic referral cohort, 12/1078 (1.1%) were positive for anti-Ku antibodies, nine showing low and three high titres. The diagnoses of the three high positive anti-Ku positive patients were: probable SLE, mixed connective tissue disease (MCTD) and ANA positive RA. Conclusion: Anti-Ku antibodies detected by chemiluminescent immunoassay are most prevalent in SLE. When found in AIM and SSc, they were associated with overlap syndrome and early SSc. Lupus (2016) 25, 889-896.

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Camptocormia with trigeminal involvement revealing myositis with anti-Ku antibodies

et al. 2019

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Facial nerve palsy and anti-Ku autoantibodies

Cited by 3 publications

References 11 publications

Single-specificity anti-Ku antibodies in an international cohort of 2140 systemic sclerosis subjects

Single-specificity anti-Ku antibodies in an international cohort of 2140 systemic sclerosis subjects

Clinical and serological associations of autoantibodies to the Ku70/Ku80 heterodimer determined by a novel chemiluminescent immunoassay

Camptocormia with trigeminal involvement revealing myositis with anti-Ku antibodies

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