Facial nerve palsy with acute otitis media associated with EB virus infection

Yamaguchi, Makoto; Suzuki, Michio; Morita, Makoto; Hasegawa, Shinji; Ito, Yoshinori

doi:10.1111/ped.14451

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…EBV-infected patients can exhibit a wide spectrum of clinical courses, ranging from asymptomatic to IM to malignant diseases. Cases of EBV infection presenting with otitis media preceding facial nerve palsy, as in our case, have rarely been reported in pediatric patients [10,11]. Although the underlying mechanism remains uncertain, it has been theorized that EBV, followed by a secondary bacterial infection, might be involved in developing otitis media and mastoiditis, leading to inflammation and edema within the tympanic cavity, which in turn causes facial nerve compression resulting in facial palsy [11].…”

Section: Case Reportmentioning

confidence: 67%

See 1 more Smart Citation

Case of Chronic Active Epstein-Barr Virus Infection Developed Hemophagocytic Lymphohistiocytosis after COVID-19 Infection

Jo,

Jung,

Lim

et al. 2023

Clin Pediatr Hematol Oncol

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In children, prolonged primary Epstein-Barr virus (EBV) infection or reactivation may lead to the development of T or natural killer cell lymphoproliferative disorders, classified as chronic active EBV infection (CAEBV). CAEBV is a prolonged systemic illness lasting beyond three months, with elevated EBV DNA levels in the serum or affected tissue and a lack of underlying immunodeficiency. Notably, EBV is the most common virus that induces secondary hemophagocytic lymphohistiocytosis (HLH), and Coronavirus disease 2019 (COVID-19) has been reported to trigger HLH. We present the case of a 20-year-old Korean male who was diagnosed with CAEBV and developed HLH after being infected with COVID-19. The patient met 7 out of 8 criteria for HLH. Following treatment with corticosteroids and intravenous immunoglobulin, the patient recovered from HLH without additional chemotherapy. HLH treatment should be tailored to each patient based on clinical presentation and disease severity. Prolonged and regular evaluation for developing HLH or lymphoma is necessary for patients with CAEBV.

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Section: Case Reportmentioning

confidence: 67%

“…Additionally, corticosteroids for inflammation control and surgical drainage of pus can be considered based on the patient's condition. However, the efficacy of using the antiviral agent acyclovir as a treatment option is uncertain [10,11]. contributes to secondary HLH [13].…”

Section: Case Reportmentioning

confidence: 99%

Case of Chronic Active Epstein-Barr Virus Infection Developed Hemophagocytic Lymphohistiocytosis after COVID-19 Infection

Jo,

Jung,

Lim

et al. 2023

Clin Pediatr Hematol Oncol

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“…Complete recovery of the facial nerve was documented in 4 patients, whereas a slight paresis occurred in one patient two years after the hospitalization. Recently, Yamaguchi et al have reported two cases of 18 and 19-month-old female children with unilateral facial nerve palsy with ipsilateral AOM and primary EBV infection [ 6 ]. They received oral corticosteroids and vitamin B12 supplementation, and both recovered after 12 and 6 weeks, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…In this context, facial nerve palsy with AOM associated with Epstein-Barr virus (EBV) infection has been rarely observed [ 5 , 6 ]. Here, we describe a case of a previously healthy male child with acute onset of AOM-related facial nerve palsy associated with recent EBV infection.…”

Section: Introductionmentioning

confidence: 99%

Acute otitis media-related facial nerve palsy in a child: a case report and a literary review

et al. 2023

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Background Acute otitis media has become a rare cause of facial palsy in children. A high index of suspicion is essential to achieve the diagnosis and to properly treat this condition to avoid permanent neurological sequelae. Case presentation A case of acute otitis media-related facial nerve palsy in an 18 months-old child is described and a review of the recent literature about the clinical presentation, diagnosis, and management of this condition is performed. Conclusions Facial paralysis is an uncommon complication of acute otitis media that requires appropriate care. As highlighted in our report, the treatment of facial nerve palsy secondary to otitis media should be conservative, using antibiotics and corticosteroids. The role of antiviral is still a matter of debate. Myringotomy and a ventilation tube should be added when spontaneous perforation of the tympanic membrane is not present. More aggressive surgical approach should be considered only when there is no significant improvement.

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“…In adults, AOM is not common; however adults have up to 10 time's greater chance of developing peripheral facial paralysis [PFP] as a complication than pediatrics [3] .…”

Section: Introductionmentioning

confidence: 99%

Facial Nerve Paralysis as A Complication of Acute Otitis Media

Ramadan

Elsaied

Hassan

2021

International Journal of Medical Arts

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Background: Facial nerve paralysis is not a very frequent association with acute otitis media (AOM). The pathophysiology and treatment of this condition still under debate.Aim of the Work: to review the treatment strategies and extent of recovery in patients with facial nerve paralysis after AOM. Patients and Methods:The study was a retrospective study. Authors reviewed a total of 4710 cases of AOM seen during the period form 2010 to 2020. Fourty cases developed facial nerve paralysis. All were reviewed for epidemiological data and clinical assessment. Facial palsy was graded by House-Brackmann scale. All patients were treated with antibiotics combined with oral or intravenous corticosteroids. Myringotomy with or without application of a ventilation and mastoidectomy without decompression of the facial nerve were performed in selected cases.Result: Normal facial function was resumed to normal in all patients. The paralysis was mainly of acute onset (90.0%) and otorrhea reported among 12.5%. The initial paralysis grade was mainly grade IV (41.3%) followed by grade III (26.3%). The topography was mainly infrageniculate (86.3%). A collected material for bacteriology was reported for 40.0%, and 53.1% of them had negative culture. The most common detected organism was staphylococcus aureus (18.8%). Myringotomy was done for 7.5%, aspiration for 10.0% and Mastoidectomy for 10.0%. The overall outcome was good among 90.0% and bad among 10.0%. The duration for complete cure in cases with good outcome not exceeded 3 months. Only lower initial grade on House-Brackmann scale and infrageniculate topography were associated with favorable outcome. Conclusion:The management of facial nerve paralysis due to acute otitis media could be conservative by antibiotics with corticosteroids.

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Facial nerve palsy with acute otitis media associated with EB virus infection

Cited by 5 publications

References 5 publications

Case of Chronic Active Epstein-Barr Virus Infection Developed Hemophagocytic Lymphohistiocytosis after COVID-19 Infection

Case of Chronic Active Epstein-Barr Virus Infection Developed Hemophagocytic Lymphohistiocytosis after COVID-19 Infection

Acute otitis media-related facial nerve palsy in a child: a case report and a literary review

Facial Nerve Paralysis as A Complication of Acute Otitis Media

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