Facial Rejuvenation with a Nonablative 1320 nm Nd:YAG Laser

Trelles, Mario A.; Allones, Inés; Luna, Ricardo

doi:10.1097/00042728-200102000-00003

Cited by 51 publications

(78 citation statements)

References 10 publications

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“…11,15-17 Trelles et al 17 reported disappointing results after treating 10 patients with a 1320-nm Nd:YAG laser in a series of 8 treatments over a 4-week period, with only 2 of 10 patients expressing satisfaction with the results of their treatment. However, Trelles 18 followed up with a letter to the editor indicating that unpublished long-term data showed better results than the preliminary study, and that 4 weeks was not sufficient time to draw conclusions about the efficacy of the treatments.…”

Section: Commentmentioning

confidence: 99%

Combination 532-nm and 1064-nm Lasers for Noninvasive Skin Rejuvenation and Toning

Lee¹

2003

Arch Dermatol

129

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Background: Noninvasive techniques for skin rejuvenation are quickly becoming standard in the treatment of mild rhytids and overall skin toning. Multiple laser wavelengths and modalities have been used with varying degrees of success, including 532-nm, 585-nm, 1064nm, 1320-nm, 1450-nm, and 1540-nm wavelengths. Objectives: To evaluate a combination technique using a long-pulsed, 532-nm potassium titanyl phosphate (KTP) laser and a long-pulsed 1064-nm Nd:YAG laser, separately and combined, for noninvasive photorejuvenation and skin toning and collagen enhancement and to establish efficacy and degree of success.Design: Prospective nonrandomized study with longitudinal follow-up.Setting: Private dermatologic surgery and laser practice.Methods: A total of 150 patients, with skin types I through V, were treated with long-pulsed KTP 532-nm and long-pulsed Nd:YAG 1064-nm lasers, separately and combined. For the KTP 532-nm laser, the fluences varied between 7 to 15 J/cm 2 at 7-to 20-millisecond pulse durations with a 2-mm handpiece and 6 to 15 J/cm 2 at 30-to 50-millisecond pulses with a 4-mm handpiece. The 1064-nm Nd:YAG laser fluences were set at 24 to 30 J/cm 2 for a 10-mm handpiece. These energies were delivered at 30-to 65-millisecond pulse durations. All subjects were treated at least 3 times and at most 6 times, depending on patient satisfaction level, at monthly intervals and were observed for up to 18 months after the last treatment.Main Outcome Measures: All patients were asked to fill out a "severity scale" on which redness, pigmentation, rhytids, skin tone/tightness, texture, and patient satisfaction were noted before and after each treatment. Redness, pigmentation, rhytids, skin tone/tightness, and texture were also evaluated by the physician and another observer.Results: After 3 to 6 treatments, 50 patients treated with the 532-nm KTP laser alone showed improvement of 70% to 80% in redness and pigmentation, 30% to 50% in skin tone/tightening, 30% to 40% in skin texture, and 20% to 30% in rhytids. Another 50 patients treated with the 1064-nm Nd:YAG laser alone showed improvement of 10% to 20% in redness, 0% to 10% in pigmentation, 10% to 30% in skin tone/tightening, 20% to 30% in skin texture, and 10% to 30% in rhytids. The third group of 50 patients treated with both KTP and Nd:YAG lasers showed improvement of 70% to 80% in redness and pigmentation, 40% to 60% in skin tone/tightening, 40% to 60% in skin texture, and 30% to 40% in rhytids. Skin biopsy specimens taken at 1-, 2-, 3-, and 6-month intervals demonstrated new collagen formation. Conclusions:All 150 patients exhibited mild to moderate improvement in the appearance of rhytids, moderate improvement in skin toning and texture, and great improvement in the reduction of redness and pigmentation. The KTP laser used alone produced results superior to those of the Nd:YAG laser. Results from combination treatment with both KTP and Nd:YAG lasers were slightly superior to those achieved with either laser alone.

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Section: Commentmentioning

confidence: 99%

Combination 532-nm and 1064-nm Lasers for Noninvasive Skin Rejuvenation and Toning

Lee¹

2003

Arch Dermatol

129

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“…Although non-ablative laser treatment has delivered increased clinical safety, this has often come at a cost of predictable and consistent efficacy [9,10]. More recently, a major advance in non-ablative laser treatment, termed fractional photothermolysis, was reported [11].…”

Section: Introductionmentioning

confidence: 99%

Ex vivo histological characterization of a novel ablative fractional resurfacing device

et al. 2006

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Background and Objectives: We introduce a novel CO 2 laser device that utilizes ablative fractional resurfacing for deep dermal tissue removal and characterize the resultant thermal effects in skin. Study Design/Materials and Methods: A prototype 30 W, 10.6 mm CO 2 laser was focused to a 1/e 2 spot size of 120 mm and pulse duration up to 0.7 milliseconds to achieve a microarray pattern in ex vivo human skin. Lesion depth and width were assessed histologically using either hematoxylin & eosin (H&E) or lactate dehyrdogenase (LDH) stain. Pulse energies were varied to determine their effect on lesion dimensions. Results: Microarrays of ablative and thermal injury were created in fresh ex vivo human skin irradiated with the prototype CO 2 laser device. Zones of tissue ablation were surrounded by areas of tissue coagulation spanning the epidermis and part of the dermis. A thin condensed lining on the interior wall of the lesion cavity was observed consistent with eschar formation. At 23.3 mJ, the lesion width was approximately 350 mm and depth 1 mm. In this configuration, the cavities were spaced approximately 500 mm apart and interlesional epidermis and dermis demonstrated viable tissue by LDH staining. Conclusion: A novel prototype ablative CO 2 laser device operating in a fractional mode was developed and its resultant thermal effects in human abdominal tissue were characterized. We discovered that controlled microarray patterns could be deposited in skin with variable depths of dermal tissue ablation depending on the treatment pulse energy. This is the first report to characterize the successful use of ablative fractional resurfacing as a potential approach to dermatological treatment. Lasers Surg. Med. 39:87-95, 2007. ß

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“…Later Goldberg performed a series of clinical studies with histologic examinations to prove the collagen remodeling effects of Q-switched 1,064-nm Nd:YAG laser [2,3]. The 1,320-nm Nd:YAG laser with a dynamic surface cooling device was the first laser system specifically designed for the purpose of non-ablative skin rejuvenation [4][5][6]. Trelles et al [5] investigated the histological changes in human skin 6 weeks after 8 treatments with the 1,320-nm Nd:YAG laser and observed that there is an increase in the number and density of collagen fibers, indicating some compaction in the remodeling process, less interfibrillary space, and good linear orientation of the fibers parallel to the dermoepidermal junction.…”

Section: Introductionmentioning

confidence: 99%

“…The 1,320-nm Nd:YAG laser with a dynamic surface cooling device was the first laser system specifically designed for the purpose of non-ablative skin rejuvenation [4][5][6]. Trelles et al [5] investigated the histological changes in human skin 6 weeks after 8 treatments with the 1,320-nm Nd:YAG laser and observed that there is an increase in the number and density of collagen fibers, indicating some compaction in the remodeling process, less interfibrillary space, and good linear orientation of the fibers parallel to the dermoepidermal junction. The pulsed dye laser (PDL) is commonly used to treat port wine stains, hemangiomas, telangiectasias, and other vascular anomalies [7,8].…”

Section: Introductionmentioning

confidence: 99%

Laser induced collagen remodeling: A comparative study in vivo on mouse model

et al. 2008

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Background and Objective: Many lasers have claimed the clinical efficacy on skin rejuvenation. In this study, the mechanisms of laser induced collagen remodeling were explored systematically on a Kunming (KM) mouse model in vivo by comparing the different non-ablative laser effects using four different laser treatment modalities. Materials and Methods: The dorsal skin of KM mice was exposed by depilation before the laser treatments. Four laser treatment modalities were used: the 595-nm pulsed dye laser (PDL) (10 ms), 1,320-nm neodymium-yttriumaluminum garnet (Nd:YAG) laser (0.35 ms), 1,064-nm Nd:YAG laser with Q-switched (5 ns), and long-pulsed (0.3 ms) mode. Each modality exposed one side of the mouse dorsal skin leaving the other side as the contralateral control. Then skin histology, fibroblast number, and the genesis of collagen type I and III were studied by comparing the treatment site and control site at 1 hour, 1 day, 1 week, 3 weeks, 4 weeks, and 8 weeks after laser treatment. Hydroxyproline content of the skin tissue was measured 4 weeks and 8 weeks after laser exposure. Results: All laser treatments led to marked improvements in dermal layer thickness and collagen fiber density, and the increase in fibroblast number and hydroxyproline content compared with their own controls. Collagen synthesis and remodeling induced by the Q-switched 1,064-nm laser was most effective 4 weeks after treatment, while there was no significant difference among the other three modalities. Among the new collagen genesis after the different laser treatments, collagen type III increased sharply after the Q-switched 1,064-nm laser treatment whereas more collagen type I was elicited by the other laser treatment modalities. Conclusions: The efficacy of photo-mechanical effects in promoting more effectively the synthesis of collagen type III, whereas the photo-thermal effect favored more the formation of collagen type I.

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Facial Rejuvenation with a Nonablative 1320 nm Nd:YAG Laser

Cited by 51 publications

References 10 publications

Combination 532-nm and 1064-nm Lasers for Noninvasive Skin Rejuvenation and Toning

Combination 532-nm and 1064-nm Lasers for Noninvasive Skin Rejuvenation and Toning

Ex vivo histological characterization of a novel ablative fractional resurfacing device

Laser induced collagen remodeling: A comparative study in vivo on mouse model

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