Facial Rejuvenation with Concentrated Lipograft—A 12 Month Follow-Up Study

Prantl, Lukas; Brix, Eva; Kempa, Sally; Felthaus, Oliver; Eigenberger, Andreas; Brébant, Vanessa; Anker, Alexandra; Strauss, Catharina

doi:10.3390/cells10030594

Cited by 20 publications

(15 citation statements)

References 41 publications

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“…In 17% of patients, fat tissue necrosis or oil cysts were detected post-operatively without the need for biopsies or revision surgery. The progressive improvement and optimization, among others of the preparation technique by the Cell Enriched Lipotransfer (CELT) method, will further improve the complication and healing rates with a higher engraftment (over 90%) of the lipoaspirate in the future [ 26 – 28 ].…”

Section: Discussionmentioning

confidence: 99%

Autologous fat grafting for breast reconstruction after breast cancer: a 12-year experience

Kempa

Brix

Heine

et al. 2021

Arch Gynecol Obstet

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Purpose The aim of our study was to examine the surgical outcome and complications (efficiency) as well as the incidence of locoregional recurrence and distant metastases (oncological safety) in patients who underwent autologous fat grafting (AFG) of the breast following breast cancer surgery. Methods In our monocentric cohort study, retrospective and prospective data were collected from all consecutive patients who underwent AFG after breast cancer between 2008 and 2020; a total of 93 patients met the inclusion criteria. Results Our long-term results showed no increase in tumor recurrence and distant metastases in the studied collective when compared to the available literature. We observed 1 local recurrence (1.1%), 2 distant metastases (2.2%), and 1 tumor-related death (1.1%). There was a high degree of patient satisfaction; 67.12% of patients reported adequate satisfaction with autologous fat grafting. Conclusion Currently, to our knowledge, this is the study with the longest follow-up time (mean 6.7 years after AFG and 11.5 years after tumor resection). The results of our clinical study will contribute to improve evidence in the broad field of AFG, adipose stem cell and tumor research. Consistent with our study, the literature review shows a clear tendency of clinical trial results with a low incidence rate of tumor recurrence and metastasis following the use of AFG. AFG seems to be a safe procedure also after breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Autologous fat grafting for breast reconstruction after breast cancer: a 12-year experience

Kempa

Brix

Heine

et al. 2021

Arch Gynecol Obstet

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“…Second, we can transplant the mechanically stable fat (after the second centrifugation) with properties comparable to those of the target tissue, thereby leading to satisfying long-term results. This has already been demonstrated in one of our clinical studies on facial lipofilling, offering good long-term results over one year, even in areas of mechanical stress such as the nasolabial fold or periorbital area [ 26 ].…”

Section: Discussionmentioning

confidence: 82%

The Effects of Shear Force-Based Processing of Lipoaspirates on White Adipose Tissue and the Differentiation Potential of Adipose Derived Stem Cells

Eigenberger

Felthaus

Schratzenstaller

et al. 2022

Cells

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Autologous lipotransfer is a promising method for tissue regeneration, because white adipose tissue contains a heterogeneous cell population, including mesenchymal stem cells, endothelial cells, immune cells, and adipocytes. In order to improve the outcome, adipose tissue can be processed before application. In this study, we investigated changes caused by mechanical processing. Lipoaspirates were processed using sedimentation, first-time centrifugation, shear-force homogenization, and second-time centrifugation. The average adipocyte size, stromal vascular cell count, and adipocyte depot size were examined histologically at every processing step. In addition, the adipose derived stem cells (ADSCs) were isolated and differentiated osteogenically and adipogenically. While homogenization causes a disruption of adipocyte depots, the shape of the remaining adipocytes is not changed. On average, these adipocytes are smaller than the depot adipocytes, they are surrounded by the ECM, and therefore mechanically more stable. The volume loss of adipocyte depots leads to a significant enrichment of stromal vascular cells such as ADSCs. However, the mechanical processing does not change the potential of the ADSCs to differentiate adipogenically or osteogenically. It thus appears that mechanically processed lipoaspirates are promising for the reparation of even mechanically stressed tissue as that found in nasolabial folds. The changes resulting from the processing correspond more to a filtration of mechanically less stable components than to a manipulation of the tissue.

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“…In previous work, we demonstrated that enriched autologous fat grafting offers good long-term results in patients presenting midface deficiency, with the procedure clearly improving facial volume loss and skin quality. [3] In this study, we examine the long-term outcomes for patients with congenital breast asymmetry who underwent either lipograft or silicone implant augmentation. Since both surgical methods are described differently in the literature, we present the protocols we implemented below.…”

Section: Introductionmentioning

confidence: 99%

Implants Versus Lipograft: Analysis of Long-Term Results Following Congenital Breast Asymmetry Correction

et al. 2022

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Aims Congenital breast asymmetry represents a particular challenge to the classic techniques of plastic surgery given the young age of patients at presentation. This study reviews and compares the long-term results of traditional breast augmentation using silicone implants and the more innovative technique of lipografting. Methods To achieve this, we not only captured subjective parameters such as satisfaction with outcome and symmetry, but also objective parameters including breast volume and anthropometric measurements. The objective examination was performed manually and by using the Vectra® H2 photogrammetry scanning system. Results Differences between patients undergoing either implant augmentation or lipograft were revealed not to be significant with respect to patient satisfaction with surgical outcome (p = 0.55) and symmetry (p = 0.69). Furthermore, a breast symmetry of 93 % was reported in both groups. Likewise, no statistically significant volume difference between the left and right breasts was observed in both groups (p < 0.41). However, lipograft patients needed on average 2.9 procedures to achieve the desired result, compared with 1.3 for implant augmentation. In contrast, patients treated with implant augmentation may require a number of implant changes during their lifetime. Conclusion Both methods may be considered for patients presenting with congenital breast asymmetry. Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Facial Rejuvenation with Concentrated Lipograft—A 12 Month Follow-Up Study

Cited by 20 publications

References 41 publications

Autologous fat grafting for breast reconstruction after breast cancer: a 12-year experience

Autologous fat grafting for breast reconstruction after breast cancer: a 12-year experience

The Effects of Shear Force-Based Processing of Lipoaspirates on White Adipose Tissue and the Differentiation Potential of Adipose Derived Stem Cells

Implants Versus Lipograft: Analysis of Long-Term Results Following Congenital Breast Asymmetry Correction

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