Facile access to trifluoromethyl propargyl alcohol by metal-free transfer hydrogenation and cyanation of alkynyl ketones

Abstract

We report an efficient synthetic route for metal-free hydroboration and cynosilyation of a wide range of alkynyl trifluoromethyl ketones using pinacolborane (4,4,5,5-tetramethyl-1,3,2-dioxaborolane) and trimethylsilyl cyanide under mild reaction conditions at...