Facile and Green Synthesis of Saturated Cyclic Amines

Abstract

Single-nitrogen containing saturated cyclic amines are an important part of both natural and synthetic bioactive compounds. A number of methodologies have been developed for the synthesis of aziridines, azetidines, pyrrolidines, piperidines, azepanes and azocanes. This review highlights some facile and green synthetic routes for the synthesis of unsubstituted, multisubstituted and highly functionalized saturated cyclic amines including one-pot, microwave assisted, metal-free, solvent-free and in aqueous media.

One-Pot Synthesis of Coumarins Unsubstituted on the Pyranic Nucleus Catalysed by a Wells–Dawson Heteropolyacid (H₆P₂W₁₈O₆₂)

“…The catalytic method was also applied successfully to synthesize various substituted coumarins, from the corresponding phenols and ethyl 3, 3-diethoxypropionate. Carrying out reactions under solvent-free conditions is an important strategy in organic synthesis as it significantly reduces production waste and precludes post-synthesis steps, such as product isolation and solvent recycling [47][48][49]. This method provides a novel greener and safer choice for the synthesis of coumarins unsubstituted on the pyranic nucleus.…”

Stereocontrolled Synthesis of Functionalized Azaheterocycles from Carbocycles through Oxidative Ring Opening/Reductive Ring Closing Protocols

“…In organic and pharmaceutical chemistry, the creation of novel saturated N ‐heterocycles is a field explored deeply. However, due to the increasing importance of these scaffolds, the development of novel, efficient, cost effective, selective, and stereocontrolled protocols for these derivatives is a continuous challenge in modern chemistry …”

A de novo synthetic method to the access of N-substituted benzazepines

“…Functionalized azepanes constitute important components of several biologically relevant natural and non-natural products with interesting pharmaceutical properties. Some representatives of this class of azaheterocycles are known as antiviral agents, glycosidase inhibitors, anticancer agents or antidiabetics [1][2][3][4][5]. Therefore, in view of their medicinal relevance, an increasing number of synthetic methods have been described in recent years for the construction of highly substituted azepane derivatives [6][7][8][9][10].…”