Facile and Robust Antibacterial Functionalization of Medical Cotton Gauze with Gallic Acids to Accelerate Wound Healing

Abstract

The clinical treatment of wounds with medical cotton gauze often encounters inflammation and excessive immune response triggered by bacterial infections, which can significantly prolong the wound healing process. It is, therefore, of great significance to develop functional gauzes with broad-spectrum antibacterial and anti-inflammatory activities. Herein, we report a convenient, robust, and practical strategy to functionalize medical cotton gauze by covalently immobilizing plant-derived gallic acids. The obtained GA@Gauze exhibits not only excellent biosafety and washing durability but also broad-spectrum bacterial antiadhesion and bactericidal activities. More importantly, in vivo experiments confirm that GA@Gauze can effectively reduce the bacterial invasion and regulate inflammatory responses, resulting in faster production of collagen fibers and accelerated wound healing. Therefore, this simple and powerful route has great potential for fabricating the next-generation functional gauzes for clinical treatment of wounds.

Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration

“…12,43 Pathogenic bacterial infection was one of the main obstacles to wound healing. 25,44 Indeed, in this study, the assessment of the antimicrobial properties of GZ, GP, and GPZ sponges by measuring their contact-killing activity against S. aureus and E. coli, as shown in Figure 2H, revealed that the GPZ sponge exhibited a remarkable kill effect of the growth of two microbes, above ≥99.9% after 2 h incubation and contact, indicating a strong and broad-spectrum antimicrobial activity. The bacterial killing rate of GP and GZ was between 40 and 60%, and their sterilization relied on the catechol structure to inhibit bacterial growth or the release of zinc ions to damage the bacterial structure.…”

“…The E. coli and S. aureus solution concentrations were diluted to 10 5 CFU•mL −1 , and the samples were added to 37 °C constant temperature culture. 25 At the reaction time of 0 and 2 h, 20 μL of culture medium was absorbed and coated on the plate. The colonies in the plate were photographed and counted after 20 h of culture.…”

“…The antioxidant ability was determined by measuring the scavenging rate of DPPH radicals. 25 Briefly, 100 mg of sponge (Gel, GP, GZ, and GPZ) cut into pieces was immersed into 30 mL of 0.15 mM DPPH solution in ethyl alcohol. After the solution was placed in the dark for 1 h, 2 mL of the solution was taken out to measure the absorbance at 517 nm.…”

Dynamic Metal–Phenolic Coordination Complexes for Versatile Surface Nanopatterning

“…In addition, oxidized quinones may also react with amino groups via Michael addition and Schiff base reaction. , Therefore, MPnPs can be employed as a general platform for the covalent immobilization of proteins; most proteins have large numbers of amino groups on their surfaces. As a proof-of-concept, we introduced fibronectin, a large glycoprotein in the extracellular matrix onto the TA–Fe nanopatterns.…”

Recent developments in preparation, properties, and applications of superhydrophobic textiles

“…In summary of the potential applications of superhydrophobic textiles, the cotton and polyester fabrics are more widely used than woven fabrics in research, either plain or twill, for better liquid-resistance. The resulting products could obtain the desired superhydrophobicity and be successfully employed in applications of oil-water separation, [114][115][116] self-cleaning, [117][118][119] sewage disposal, 120 anti-icing, 121 anti-corrosion, 122 drag-reduction of fluids, 123 medical gauze and bandaids, [124][125][126] and protective clothing. [127][128][129][130][131]…”