Facile and sensitive determination of urinary mandelic acid by combination of metal organic frameworks with microextraction by packed sorbents

Biomedical Chromatography

Nematollahi

et al. 2019

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For the analysis of methylhippuric acids (MHAs) in human urine samples, in this study, a new method based on the metal–organic framework (MOF) of MIL‐53‐NH2 (Al) in microextraction by packed sorbent (MEPS) was developed. The synthesis of MIL‐53‐NH2 (Al) was characterized by Fourier transform infrared spectra, field emission‐scanning electron microscopy and X‐ray diffraction. Response surface methodology was used to investigate the influences of several parameters including type and volume of elution, type of conditional solvent, sample volume and extraction cycle on MEPS efficiency. The results showed good recoveries (>94%) and excellent extraction efficiencies (>96%) at three different concentrations of 50, 500 and 1500 μg ml−1 (as low, mid and high concentrations, respectively) of MHA isomers. Calibration curves of MHAs were linear over the concentration range of 1–1500 μg ml−1, with high correlation coefficients (r ≥ 0.998). The reproducibility of the proposed MIL‐53‐MEPS for determination of three isomers of MHA was found to be in the range of 3.5–11.1%. After optimization of the proposed technique, it was used to analyze MHAs in urine samples of workers exposed to xylenes in a petrochemical plant in Asalouyah, Iran. The results indicated that the MOF–MEPS method was selective, sensitive, rapid and efficient for the extraction of urinary MHAs. The technique is also environmentally friendly and inexpensive, and the MOF sorbent is reusable.

Section: Resultsmentioning

confidence: 99%

Determination of urinary methylhippuric acids using MIL‐53‐NH₂ (Al) metal–organic framework in microextraction by packed sorbent followed by HPLC–UV analysis

Pirmohammadi

Biomedical Chromatography

Nematollahi

et al. 2019

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“…The MOF was also modified with nanoparticle silica (MOF‐5@ SBA‐15) packed in the MEPS technique to determine the urinary mandelic acid and Mile‐53 used to analyze methylhippuric acid in urine samples. Various studies have investigated and optimized the effects of some parameters, including volume of samples, type and volume of elution, and amount of washing solvents in both methods (Pirmohammadi et al, 2020; Rahimpoor et al, 2019). The limit of detection and limit of quantitation were dramatically lower in the new techniques than in conventional methods recommended by National Institute for Occupational Safety and Health (NIOSH) method‐8,301 (NIOSH, 2003).…”

Section: Spmementioning

confidence: 99%

A review of new adsorbents for separation of BTEX biomarkers

Pirmohammadi

Biomedical Chromatography

2021

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The biomarker analysis of benzene, toluene, ethylbenzene and xylene (BTEXs) in biological samples is the primary technique for evaluating these compounds in occupational and environmental exposures. The BTEX biomarkers are widely used to study the BTEX distribution in the environment and workplaces. Liquid–liquid extraction and solid‐phase liquid extraction are among the most commonly used conventional methods to analyze biological indices of BTEXs. New methods have been proposed to analyze BTEX biomarkers using novel adsorbents such as sol–gel composite nanotubes, molecularly imprinted polymers and metal–organic frameworks, which are based on the application of needle trap devices, microextraction by packed sorbent, and solid‐phase microextraction techniques. This paper provides an overview of new methods since 2015 regarding applying microextraction methods based on new adsorbents and analyzing BTEX biomarker compounds for occupational and environmental exposures. The results were compared with the liquid‐phase microextraction methods recommended for urinary BTEX biomarkers.

“…The footprint of MOFs can be seen in chemical applications such as separation, storage, catalysis, drug delivery, pollution analysis, and electrochemical applications such as supercapacitors, electrocatalysis, and sensors. [18][19][20][21][22][23] The positive outlook comes from the diversity of structures, the exibility of synthesis procedures, high surface area (up to 6000 m 2 g À1 ), adjustable pores, selective adsorption, reusability, and suitable chemical and thermal stability as some of the advantages of MOFs. [24][25][26][27] But MOFs suffer from a weakness compared to zeolites and activated carbons.…”

Section: Introductionmentioning

confidence: 99%

Determination of halogenated hydrocarbons in urine samples using a needle trap device packed with Ni/Zn–BTC bi-MMOFviathe dynamic headspace method

et al. 2021

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