Facile biofabrication, characterization, evaluation of photocatalytic, antipathogenic activity and in vitro cytotoxicity of zinc oxide nanoparticles

Rajkumar, Krishnasamy Sekar; Sridhar, Arun; Babu, M.; Balaji, Perumalsamy; Srinivasan, Sivasubramanian; Vignesh, V.; Ramasamy, Thirumurugan

doi:10.1016/j.bcab.2019.101436

Cited by 20 publications

(7 citation statements)

References 82 publications

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“…Additionally, further investigations established that ZnO NPs induced cell cycle arrest at the G1 phase. 21 Our results are aligned with previous studies, confirming the cytotoxic impact of ZnO NPs. Jasim and their colleagues also examined into the cytotoxic impacts of ZnO nanoparticles (NPs) on colon cancer cell lines.…”

Section: Discussionsupporting

confidence: 92%

Synthesis of ZnO and PEG-ZnO nanoparticles (NPs) with controlled size for biological evaluation

Khan,

Ahmad,

Hayat

et al. 2024

RSC Adv.

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Section: Discussionsupporting

confidence: 92%

Synthesis of ZnO and PEG-ZnO nanoparticles (NPs) with controlled size for biological evaluation

Khan,

Ahmad,

Hayat

et al. 2024

RSC Adv.

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“…Hence, being tough and non selective, the generated reactive oxygen species can result in promising dye degradation at the surface of the photocatalyst. Similar results were noted with ZnO based nanocomposites synthesized using S. lycopersicum, coconut husk, Allium cepa L, Syzygium cumini , Ruellia tuberose, Artocarpus heterophyllus for degradation of chemical dyes such as, Congo red, methylene blue, metanil yellow, crystal violet, and malachite green ( Vidya et al, 2017 ; Rajkumar et al, 2019 ; Preethi et al, 2020 ; Sadiq et al, 2021 ; Vasantharaj et al, 2021 ; Priyadharshini et al, 2022 ). In view of the background, it is evident that Ag mixed phytogenic ZnOPs mediated dye removal can be a powerful strategy for dye contaminated wastewater treatment.…”

Section: Discussionsupporting

confidence: 79%

Catalytic dye degradation by novel phytofabricated silver/zinc oxide composites

et al. 2022

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Phytofabrication of the nanoparticles with exotic shape and size is an attractive area where nanostructures with noteworthy physicochemical and optoelectronic properties that can be significantly employed for photocatalytic dye degradation. In this study a medicinal plant, Plumbago auriculata leaf extract (PALE) was used to synthesize zinc oxide particles (ZnOPs) and silver mixed zinc oxide particles (ZnOAg1Ps, ZnOAg10Ps, ZnO10Ag1Ps) by varying the concentration of the metal precursor salts, i.e. zinc acetate and silver nitrate. The PALE showed significantly high concentrations of polyphenols, flavonoids, reducing sugar, starch, citric acid and plumbagin up to 314.3 ± 0.33, 960.0 ± 2.88, 121.3 ± 4.60, 150.3 ± 3.17, 109.4 ± 2.36, and 260.4 ± 8.90 μg/ml, respectively which might play an important role for green synthesis and capping of the phytogenic nanoparticles. The resulting particles were polydispersed which were mostly irregular, spherical, hexagonal and rod like in shape. The pristine ZnOPs exhibited a UV absorption band at 352 nm which shifted around 370 in the Ag mixed ZnOPs with concomitant appearance of peaks at 560 and 635 nm in ZnO10Ag1Ps and ZnOAg1Ps, respectively. The majority of the ZnOPs, ZnOAg1Ps, ZnOAg10Ps, and ZnO10Ag1Ps were 407, 98, 231, and 90 nm in size, respectively. Energy dispersive spectra confirmed the elemental composition of the particles while Fourier transform infrared spectra showed the involvement of the peptide and methyl functional groups in the synthesis and capping of the particles. The composites exhibited superior photocatalytic degradation of methylene blue dye, maximum being 95.7% by the ZnOAg10Ps with a rate constant of 0.0463 s−1 following a first order kinetic model. The present result clearly highlights that Ag mixed ZnOPs synthesized using Plumbago auriculata leaf extract (PALE) can play a critical role in removal of hazardous dyes from effluents of textile and dye industries. Further expanding the application of these phytofabricated composites will promote a significant complementary and alternative strategy for treating refractory pollutants from wastewater.

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“…At the same time, most of the proposed NPs seemed to have a good efficiency against the various tumoral cells, with half maximal effective concentrations usually under 100 mg/L. For example, against breast adenocarcinoma cells (MCF-7), the best results in the MTT assay were achieved by using spherical silver nanoparticles that were obtained by using Tropaeolum majus L. leaf extracts (EC 50 = 2.49 mg/L) [24], followed by spherical gold nanoparticles that were obtained by using Anacardium occidentale L. leaves (EC 50 = 6 mg/L) [53]; the same types of NPs were also found to be efficient against human cervical epithelioid carcinoma cells (HeLa) (Ag NPs that were obtained by using Piper longum leaves-EC 50 = 5.27 mg/L [88] and Au NPs that were obtained by using Alternanthera sessilis leaves-EC 50 = 10 mg/L [99]), while the most effective nanoparticles against human lung carcinoma cells (A549) were proven to be silver NPs that were obtained by using Scorzonera calyculata aerial parts (EC 50 = 12.5 mg/L) [35], gold NPs that were obtained by using Marsdenia tenacissima leaves (EC 50 = 15 mg/L) [95], MgO NPs that were obtained by using Sargassum wightii (EC 50 = 37.5 mg/L) [70], and ZnO NPs that were obtained by using Allium cepa leaves (EC 50 = 51.25 mg/L) [66].…”

Section: Antitumoral Applicationsmentioning

confidence: 99%

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

et al. 2020

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Phytosynthesized nanoparticles represent a continuously increasing field of research, with numerous studies published each year. However, with the emerging interest in this area, the quality of the published works is also continuously increasing, switching from routine antioxidant or antimicrobial studies on trivial microbial lines to antibiotic-resistant strains or antitumoral studies. However, this increasing interest has not been not reflected in the studies regarding the toxicological effects of nanoparticles (NPs); this should be a subject of greatest interest, as the increasing administration of NPs in general (and phytosynthesized NPs in particular) could lead to their accumulation in the environment (soil, water and living organisms). The present review aims to present the most recent findings in the application of phytosynthesized NPs as antimicrobial and antitumoral agents, as well as the results regarding their toxicological potential.Materials 2020, 13, 574 2 of 32 in terms of their toxic potential towards target organisms (leading to their proposal as antimicrobial [4], antiviral [5] or cytogenotoxic agents [6]), their possible negative toxicity has not been thoroughly established. The present review aims to present the advances that have been recorded in the last year in the area of phytosynthesized nanoparticle applications and toxicity studies, as well to underline the shortcomings of the encountered approach. The literature review survey was performed on multiple databases (Scopus, Web of Science, ScienceDirect, SpringerLink, PubMed) and used the main keywords "nanoparticles" and "extract" (as the term "phytosynthesis" was not adopted by all the authors). From the returned results, only the works that were published in the last year (2019) were selected. Furthermore, a supplementary selection was performed by using keywords as "antimicrobial," "cytotoxicity," and "toxicology" (results presented in Figure 1). The results of this preliminary selection led to the return of approximately 1800 unique works (from all the databases). A preliminary validation was manually performed (by reading the keywords and abstract) in order to remove the "false-positive" results. The final validation was performed by reading the entire manuscript. The criteria for inclusion in the present review were: (i) the use of phytosynthesized nanoparticles that were obtained in the laboratory; (ii) the existence of analytical studies for the characterization of the nanoparticles; and (iii) in-depth applications reports. The review is structured in different chapters for each potential application that is related to the toxic effect of the metallic nanoparticles.

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Facile biofabrication, characterization, evaluation of photocatalytic, antipathogenic activity and in vitro cytotoxicity of zinc oxide nanoparticles

Cited by 20 publications

References 82 publications

Synthesis of ZnO and PEG-ZnO nanoparticles (NPs) with controlled size for biological evaluation

Synthesis of ZnO and PEG-ZnO nanoparticles (NPs) with controlled size for biological evaluation

Catalytic dye degradation by novel phytofabricated silver/zinc oxide composites

Phytosynthesized Metallic Nanoparticles—between Nanomedicine and Toxicology. A Brief Review of 2019′s Findings

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