Facile design of lidocaine-loaded polymeric hydrogel to persuade effects of local anesthesia drug delivery system: complete in vitro and in vivo toxicity analyses

Abstract

The principal goal of the present investigation was to enterprise new and effective drug delivery vesicle for the sustained delivery of local anesthetic lidocaine hydrochloride (LDC), using a novel combination of copolymeric hydrogel with tetrahydroxyborate (COP-THB) to improve bioactivity and therapeutic potential. To support this contention, the physical and mechanical properties, rheological characteristics, and component release of candidate formulations were investigated. An optimized formulation of COP-THB containing LDC to an upper maximum concentration of 1.5% w/w was assessed for drug crystallization. The biocompatibility of the prepared COP-THB hydrogel was exhibited strong cell survival (96%) and growth compatibility on L929 fibroblast cell lines, which was confirmed by using methods of MTT assay and microscopic observations. The COP-THB hydrogel release pattern is distinct from that of COP-THB/LDC hydrogels by the slow-release rate and the low percentage of cumulative release. In vivo evaluations were demonstrated the anesthetic effects and toxicity value of treated samples by using mice models. In addition, COP-THB/LDC hydrogels significantly inhibit in vivo tumor growth in mice model and effectively reduced it is in vivo toxicity. The pharmacological evaluation showed that encapsulation of LDC in COP-THB hydrogels prolonged its anesthetic action with favorable in vitro and in vivo compatibility. This novel design may theoretically be used in promising studies involving the controlled release of local anesthetics. HIGHLIGHTSDevelopment a modified sustained release system for the local anesthetic lidocaine. PVP-THB hydrogel to improve the pharmacological properties of the drug and their anesthetic activities. Profiles of PVP-THB/LDC showed that the effective release of associated lidocaine. This new formulation could potentially be used in future local anesthetics.

Synthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management

“…The CCK-8 assay was performed in human fibroblast 3T3 cells for 24 h to validate the biocompatibility and nontoxicity of CS-GP hydrogel and CS-GP/PC polymeric hydrogel, as well as the anesthetic effects of BPV in the dosage form (Li et al., 2021 ). Although several researchers have demonstrated that GP is a safer cross-linker than glutaraldehyde, the compatibility of composite hydrogel formulations must be validated (Liang et al., 2003 ).…”

Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics

“…The most commonly applied anesthetics for administration via DDS are bupivacaine and lidocaine. 48 , 49 Encapsulation of these drugs in advanced DDSs, such as nano- and microparticles, should facilitate improvement of retention time in the body and prolonged drug release rates at the target site. 50 Local anesthetic delivery systems developed using a variety of inorganic materials (including microparticles, lipid nanoparticles, polymeric nanoparticles, or chitosan) have been comprehensively summarized in a recent review.…”

Biopolymer-Based Hydrogel Incorporated with Naproxen Sodium and Lidocaine Hydrochloride for Controlled Drug Delivery

“…This is connected to the filling of the network space with the drug molecules interacting with the polymer through the formation of hydrogen bonds, which, as a consequence, results in the compression of the hydrogel space. The porous structure is very important in biomedical applications of hydrogels, especially in tissue regeneration [12]. Lid occurs very often in the ionized form as lidocaine hydrochloride salt.…”