Facile domino reactions in the statistically controlled product- and stereoselective synthesis of densely functionalized cis-1,4-cyclohexa-1,4-dienes and trans,trans-trisubstituted-1,2,5,6-tetrahydropyridines

Recent developments in multicomponent synthesis of structurally diversified tetrahydropyridines

“…With 100 mol% of 116, 200 mol% of aldehyde and 200 mol% of ammonium acetate in ethanol, the yield of 119 raised to 82% (Scheme 24). 48 Scheme 23 Four component synthesis of THPDS.…”