Facile fabrication of hollow mesoporous Eu 3+ -doped Gd 2 O 3 nanoparticles for dual-modal imaging and drug delivery

Shi, Hanzhu; Li, Lü; Zhang, Lingyu; Wang, Tingting; Wang, Chungang; Su, Zhong‐Min

doi:10.1016/j.dyepig.2015.07.015

Cited by 22 publications

(14 citation statements)

References 47 publications

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“…Furthermore, these obtained double‐shell hollow spheres achieved respectable MRI. It is worth mentioning that the excellent MRI was also displayed in the Gd 2 O 3 :Eu 3+ hollow structures …”

Section: Applications Of Lphssmentioning

confidence: 92%

Lanthanide‐Doped Photoluminescence Hollow Structures: Recent Advances and Applications

Zong

Wang

2019

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Lanthanide‐doped nanomaterials have attracted significant attention for their preeminent properties and widespread applications. Due to the unique characteristic, the lanthanide‐doped photoluminescence materials with hollow structures may provide advantages including enhanced light harvesting, intensified electric field density, improved luminescent property, and larger drug loading capacity. Herein, the synthesis, properties, and applications of lanthanide‐doped photoluminescence hollow structures (LPHSs) are comprehensively reviewed. First, different strategies for the engineered synthesis of LPHSs are described in detail, which contain hard, soft, self‐templating methods and other techniques. Thereafter, the relationship between their structure features and photoluminescence properties is discussed. Then, niche applications including biomedicines, bioimaging, therapy, and energy storage/conversion are focused on and superiorities of LPHSs for these applications are particularly highlighted. Finally, keen insights into the challenges and personal prospects for the future development of the LPHSs are provided.

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Section: Applications Of Lphssmentioning

confidence: 92%

Lanthanide‐Doped Photoluminescence Hollow Structures: Recent Advances and Applications

Zong

Wang

2019

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“…Therefore, the terbium doped Gd 2 O 3 nanoparticles [ 13 ], and the europium doped nanoparticles [ 14 , 15 ] have been investigated for dual mode MRI/fluorescence imaging in other studies. In addition to applications of doped Gd 2 O 3 nanoparticles in the imaging methods, the rare earth or lanthanide doped Gd 2 O 3 nanoparticles along with other materials have been studied for other biomedical applications such as drug delivery [ 16 , 17 ], tumor targeting [ 18 ], and photodynamic therapy [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Neodymium Doping on MRI Relaxivity of Gadolinium Oxide Nanoparticles

2020

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Background: Gadolinium oxide nanoparticles as positive contrast material of magnetic resonance imaging (MRI) have attracted a great attention due to the appropriate magnetic properties. One of the most desirable features of these nanoparticles is their ability of doping with other lanthanides which can change their properties. Objective: This study aimed to investigate the effect of neodymium doping on MRI relaxivity of the gadolinium oxide nanoparticles. Material and Methods: In this experimental study, the oleic acid coated gadolinium oxide nanoparticles and the neodymium doped nanoparticles were prepared by polymer pyrolysis method. X-ray diffraction test and scanning electron microscopy were used for characterization of the particles. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to investigate the in vitro cell toxicity of the nanoparticles. The r1 and r2 relaxivities were extracted from the T1 and T2 weighted MR images, respectively. Results: The average size of the cytocompatible spherical-like shape nanoparticles was 40 nm. The neodymium doped nanoparticles produced a significant decrease in the r1 relaxivity, and a 1.7 fold increase in the r2 relaxivity compared to the gadolinium oxide nanoparticles. Conclusion: Doping of neodymium into the gadolinium oxide nanoparticles suppresses the r1 relaxivity and enhances the r2 relaxivity of the nanoparticles.

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“…These outstanding optical and photochemical properties make them promising candidates for their future applications in widespread biomedical sciences. Amongst lanthanide nanomaterials, gadolinium oxide (Gd 2 O 3 ) is an ideal host matrix for doping of luminescent ion due to their excellent photochemical and thermal stability and low vibrational energy [1][2][3][5][6][7]. Additionally, Gd 2 O 3 is magnetically active and used as magnetic resonance imaging contrast agent [2][3][4]8].…”

Section: Introductionmentioning

confidence: 99%

Mesoporous silica modified luminescent Gd2O3:Eu nanoparticles: physicochemical and luminescence properties

Aldalbahi

Rahaman

Ansari

2018

J Sol-Gel Sci Technol

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Highly colloidal Gd 2 O 3 :Eu nanoparticles (core-NPs) were synthesized by thermal decomposition via weak base at low temperature. The sol-gel chemical process was employed for silica layer surface coating to increase solubility, colloidal stability, biocompatibility, and non-toxicity at the ambient conditions. XRD results indicate the highly purified, crystalline, single phase, and cubic phase Gd 2 O 3 nanocrystals. TEM image shows that the mesoporous thick silica layer was effectively coated on the core nanocrystals, which have irregular size with nearly spherical shape and grain size about 10-30 nm. An absorption spectra and zeta potential results in aqueous media revealed that solubility, colloidal stability, and biocompatibility character were enhanced from core to core-shell structure because of silica layer surface encapsulation. The samples, demonstrated excellent photoluminescence properties (dominant emission 5 D 0 → 7 F 2 transition in the red region at 610 nm), indicated to be used in optical bio-detection, bio-labeling, etc. The photoluminescence intensity of the silica shell modified core/shell NPs was suppressed relatively core-NPs; it indicates the multi-photon relaxation pathways arising from the surface coated high vibrational energy molecules of the silanol groups. The core/nSiO 2 /mSiO 2 nanocrystals display strong emission ( 5 D 0 → 7 F 2 ) transition along with excellent solubility and biocompatibility, which may find promising applications in the photonic based biomedical field.

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Facile fabrication of hollow mesoporous Eu 3+ -doped Gd 2 O 3 nanoparticles for dual-modal imaging and drug delivery

Cited by 22 publications

References 47 publications

Lanthanide‐Doped Photoluminescence Hollow Structures: Recent Advances and Applications

Lanthanide‐Doped Photoluminescence Hollow Structures: Recent Advances and Applications

Effect of Neodymium Doping on MRI Relaxivity of Gadolinium Oxide Nanoparticles

Mesoporous silica modified luminescent Gd2O3:Eu nanoparticles: physicochemical and luminescence properties

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