Facile Fabrication of Hyperbranched Polyacetal Quaternary Ammonium with pH-Responsive curcumin Release for Synergistic Antibacterial Activity

Wang, Xing; Wang, Yaqiang; Wu, Decheng

doi:10.1007/s10118-022-2884-0

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…During the endoscopic resection of digestive tract lesions, complications such as bleeding and infection are prone to occur, thereby leading to poor wound healing. [ 27,28 ] It is worth noting that ISO is a commonly used hydrophilic hemostatic drug, while TET is a hydrophobic antibacterial drug. Therefore, the simultaneous loading and controlled release of these hydrophobic and hydrophilic drugs in submucosal injection materials pose a significant challenge.…”

Section: Resultsmentioning

confidence: 99%

Synergistic Drug‐Loaded Shear‐Thinning Star Polymer Hydrogel Facilitates Gastrointestinal Lesion Resection and Promotes Wound Healing

Zhang,

Miao,

et al. 2024

Advanced Science

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Easy injection, long‐lasting barrier, and drug loading are the critical properties of submucosal injection materials for endoscopic surgery. However, conventional injectable polymers face challenges in simultaneously attaining these properties due to the inherent conflict between injectability and in situ stability. Here, a multi‐arm star polymer hydrogel (denoted as βCP hydrogel) with long‐lasting submucosal barrier (exceeding 120 min), rapid hemostasis, and sustained antibacterial properties is successfully developed by grafting poly(oligo(ethylene glycol) methyl ether methacrylate) (PEGMA) side‐chains from β‐CD via atom transfer radical polymerization (ATRP). During the onset of shearing, βCP hydrogel experiences the unwinding of polymer side‐chains between neighboring star polymers, which facilitates the process of endoscopic injectability. After submucosal injection, βCP hydrogel undergoes the winding of polymer side‐chains, thereby establishing a long‐lasting barrier cushion. Meanwhile, owing to its distinctive structures with a hydrophobic inner cavity and an outer layer of hydrophilic polymer side‐chains, βCP hydrogel enables simultaneous loading and on‐demand release of diverse categories of drugs. This unique performance can adapt to the diverse demands during different stages of wound healing in a porcine endoscopic surgery model. These results indicate an appealing prospect for new application of star polymers as a good submucosal injection material in endoscopic treatments.

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Section: Resultsmentioning

confidence: 99%

Synergistic Drug‐Loaded Shear‐Thinning Star Polymer Hydrogel Facilitates Gastrointestinal Lesion Resection and Promotes Wound Healing

Zhang,

Miao,

et al. 2024

Advanced Science

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“…Branched polymers with dendritic structures and abundant terminal groups have been an ideal crosslink to design the complex networks and advanced functions for the topological polymers and hydrogels [29][30][31][32]. Much of the research to date involves the simple crosslinking between the branched polyethyleneimine (PEI) and another polymers such as polyacrylic acid (PAA), poly(vinyl alcohol), and poly(ethylene glycol) via the multiply electrostatic interactions within a few seconds [33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Flexible Fabrication and Hybridization of Bioactive Hydrogels with Robust Osteogenic Potency

Zhu,

Hou,

Yan

et al. 2023

Pharmaceutics

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Osteogenic scaffolds reproducing the natural bone composition, structures, and properties have represented the possible frontier of artificially orthopedic implants with the great potential to revolutionize surgical strategies against the bone-related diseases. However, it is difficult to achieve an all-in-one formula with the simultaneous requirement of favorable biocompatibility, flexible adhesion, high mechanical strength, and osteogenic effects. Here in this work, an osteogenic hydrogel scaffold fabricated by inorganic-in-organic integration between amine-modified bioactive glass (ABG) nanoparticles and poly(ethylene glycol) succinimidyl glutarate-polyethyleneimine (TSG-PEI) network was introduced as an all-in-one tool to flexibly adhere onto the defective tissue and subsequently accelerate the bone formation. Since the N-hydroxysuccinimide (NHS)-ester of tetra-PEG-SG polymer could quickly react with the NH2-abundant polyethyleneimine (PEI) polymer and ABG moieties, the TSG-PEI@ABG hydrogel was rapidly formed with tailorable structures and properties. Relying on the dense integration between the TSG-PEI network and ABG moieties on a nano-scale level, this hydrogel expressed powerful adhesion to tissue as well as durable stability for the engineered scaffolds. Therefore, its self-endowed biocompatibility, high adhesive strength, compressive modulus, and osteogenic potency enabled the prominent capacities on modulation of bone marrow mesenchymal stem cell (BMSCs) proliferation and differentiation, which may propose a potential strategy on the simultaneous scaffold fixation and bone regeneration promotion for the tissue engineering fields.

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Quaternary Ammonium Compounds and Their Composites in Antimicrobial Applications

Yao,

Ye,

Zhang

et al. 2024

Adv Materials Inter

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Quaternary ammonium compounds (QACs) are well‐known for their antimicrobial properties, but their widespread use is limited due to suboptimal antimicrobial efficiency and safety concerns. Recent progress in materials science has paved the way for the development of QAC‐based composites (QACCs). QACCs with diverse compositions have shown enhanced antimicrobial effectiveness and biosafety for various applications, such as food packaging, capacitive deionization, and household antimicrobials. This review provides a comprehensive summary of the synthesis approaches and different types of QACCs. Moreover, this review examines their antimicrobial applications, taking the underlying structure‐activity relationship into consideration. In addition, this perspectives are presented on the remaining challenges and future research directions for the further development of QACCs. It is expected that this review will provide a valuable reference for the design of next generation QACC‐based antimicrobial agents.

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Facile Fabrication of Hyperbranched Polyacetal Quaternary Ammonium with pH-Responsive curcumin Release for Synergistic Antibacterial Activity

Cited by 6 publications

References 34 publications

Synergistic Drug‐Loaded Shear‐Thinning Star Polymer Hydrogel Facilitates Gastrointestinal Lesion Resection and Promotes Wound Healing

Synergistic Drug‐Loaded Shear‐Thinning Star Polymer Hydrogel Facilitates Gastrointestinal Lesion Resection and Promotes Wound Healing

Flexible Fabrication and Hybridization of Bioactive Hydrogels with Robust Osteogenic Potency

Quaternary Ammonium Compounds and Their Composites in Antimicrobial Applications

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