Facile fabrication of mesoporous ZnO nanospheres for the controlled delivery of captopril

Bakrudeen, Haja Bava; Tsibouklis, John; Reddy, Boreddy S. R.

doi:10.1007/s11051-013-1505-9

Cited by 16 publications

(8 citation statements)

References 47 publications

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“…Moreover, spherical structure has also confirmed by Miller's indices intensity values with sperulite plane orientations, when compared with mesoporous ZnO calcined at 500°C for 2 h. All the detectable XRD pattern peaks were attributed to a ZnO nanostructure and mesoporous ZnO calcined at 500°C for 2 h without detection of impurity. These are in good agreement with reference data from ZnO nanospheres (JCPDS 36-1451) [8]. The more intense diffraction peaks of auto-fluorescent ZnO nanospheres material indexed to (101), (100) and (002) indices orientation values and no peaks corresponding to other crystalline materials.…”

Section: Powder X-ray Diffraction Analysissupporting

confidence: 88%

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Auto-fluorescent mesoporous ZnO nanospheres for drug delivery carrier application

Bakrudeen

Sugunalakshmi

Reddy

2015

Materials Science and Engineering: C

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Section: Powder X-ray Diffraction Analysissupporting

confidence: 88%

“…The particles having hollow/meso nanostructures have great potential for applications in various fields like biomedical applications [1][2][3], especially in wound healing composite bandages [4], DNA, and drug delivery vehicles [5][6][7][8] due to the unique surface properties of interstitial pore space and its functionality.…”

Section: Introductionmentioning

confidence: 99%

Auto-fluorescent mesoporous ZnO nanospheres for drug delivery carrier application

Bakrudeen

Sugunalakshmi

Reddy

2015

Materials Science and Engineering: C

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“…(Figure 1a) The ZnO particles were synthesised using a starch-based aqueous solution method 24 , followed by calcination at 500 °C. Scanning electron microscopy (SEM) reveals that microspheres of c.a.…”

Section: Resultsmentioning

confidence: 99%

Surfactant-assisted ZnO processing as a versatile route to ZIF composites and hollow architectures with enhanced dye adsorption

2016

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a Metal oxides can be used as hard sacrificial templates for the preparation of multifunctional core-shell MOF-based composites following reaction with the organic linker. This is a facile method, but often structures of well-defined shape are only obtained under narrow ranges of conditions, the shape can be lost completely and low levels of MOF conversion observed. Using the prototypical framework ZIF-8 we present an alternative surfactant-assisted surface passivation strategy where the ZnO precursor particles are first coated with a guanidinium-based amphiphile. The surfactant interacts strongly with the oxide surface and allows fine-tuning of the release of Zn(II) and ZIF-8 nucleation by the level of surface coverage permitting a range of well-defined ZnO@ZIF-8 core-shell architectures to be prepared including in water. Further, selective base-etching of the oxide core provides facile access to hollow ZIF-8 and yolk-shell structures. We also demonstrate enhanced dye adsorption and recovery from aqueous mixtures using ZnO@ZIF-8 composite microspheres..

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“…Mesoporous ZnO nanospheres showing biocompatible properties were also successfully synthesized by a soluble-starch-insertion method. The mesoporous structure effectively allowed for captopril drug molecules to be efficiently loaded and released during in vitro experiments [ 51 ]. Alternatively, a porous hexagonal ZnO nanodisc structure prepared by microwave synthesis was proposed as a nanocarrier for drug delivery applications.…”

Section: Introductionmentioning

confidence: 99%

Gentamicin-Releasing Mesoporous ZnO Structures

Laurenti

Cauda

2018

Materials

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Among metal oxides, zinc oxide (ZnO) is one of the most attractive materials thanks to its biocompatible and biodegradable properties along with the existence of various morphologies featuring piezoelectric, semiconducting and photocatalytic activities. All of these structures were successfully prepared and tested for numerous applications, including optoelectronics, sensors and biomedical ones. In the last case, biocompatible ZnO nanomaterials positively influenced cells growth and tissue regeneration as well, promoting wound healing and new bone formation. Despite showing high surface areas, ZnO morphologies generally lack an intrinsic mesoporous structure, strongly limiting the investigation of the corresponding drug loading and release properties. Within this scope, this study focuses on the adsorption and release properties of high surface area, mesoporous ZnO structures using gentamicin sulfate (GS), a well known antibiotic against bacterial infections especially in orthopedics. The particular ZnO morphology was achieved starting from sputtered porous zinc layers, finally converted into ZnO by thermal oxidation. By taking advantage of this mesoporous framework, GS was successfully adsorbed within the ZnO matrix and the kinetic release profile evaluated for up to seven days. The adsorption of GS was successfully demonstrated, with a maximum amount of 263 mg effectively loaded per gram of active material. Then, fast kinetic release was obtained in vitro by simple diffusion mechanism, thus opening further possibilities of smart pore and surface engineering to improve the controlled delivery.

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Facile fabrication of mesoporous ZnO nanospheres for the controlled delivery of captopril

Cited by 16 publications

References 47 publications

Auto-fluorescent mesoporous ZnO nanospheres for drug delivery carrier application

Auto-fluorescent mesoporous ZnO nanospheres for drug delivery carrier application

Surfactant-assisted ZnO processing as a versatile route to ZIF composites and hollow architectures with enhanced dye adsorption

Gentamicin-Releasing Mesoporous ZnO Structures

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