Facile Fabrication of Methyl Gallate Encapsulated Folate ZIF-L Nanoframeworks as a pH Responsive Drug Delivery System for Anti-Biofilm and Anticancer Therapy

Abstract

Zeolitic imidazole frameworks are emerging materials and have been considered an efficient platform for biomedical applications. The present study highlights the simple fabrication of methyl gallate encapsulated folate-ZIF-L nanoframeworks (MG@Folate ZIF-L) by a simple synthesis. The nanoframeworks were characterized by different sophisticated instruments. In addition, the drug-releasing mechanism was evidenced by in vitro releasing kinetics at various pH conditions. The anti-biofilm potential confirmed by the biofilm architectural deformations against human infectious pathogens MRSA and N7 clinical strains. Furthermore, anticancer efficacy assessed against A549 lung cancer cells. The result reveals that the MG@Folate ZIF-L exposed a superior cytotoxic effect due to the pH-responsive and receptor-based drug-releasing mechanism. Based on the unique physicochemical and biological characteristics of nanoframeworks, it has overcome the problems of undesired side effects and uncontrolled drug release of existing drug delivery systems. Finally, the in vitro toxicity effect of MG@Folate ZIF-L was tested against the Artemia salina (A. salina) model organism, and the results show enhanced biocompatibility. Overall, the study suggested that the novel MG@Folate ZIF-L nanoframeworks is a suitable material for biomedical applications. It will be very helpful to the future design for targeted drug delivery systems.

Highly efficient degradation of reactive black KN-B dye by ultraviolet light responsive ZIF-8 photocatalysts with different morphologies

“…01-1136). 45 This could be the reason that its surface area is much lower than the others. Therefore, it is observed that the 2D ZIFs clearly contain distinct cushion-shaped space groups ( Cmce ) as opposed to the round-shaped spaces of ZIF-8-F1.…”

Smart Pellets for Controlled Delivery of 5-Fluorouracil

“…FU is a chemotherapeutic medication used, alone or in combination with other anticancer agents, in the treatment of many cancers affecting the cervix, head, neck, and gastrointestinal tract. The mechanism of action of FU is believed to be via the inhibition of thymidylate synthase [15,16]. The main goal of this work was to develop a new one-pot formulation capable of retaining FU and prolonging its release to elicit a site-specific FU delivery for the potential treatment of colorectal carcinoma.…”

“…The release studies have shown almost zero drug release in the first 4 h in simulated gastric fluid; additionally, the release of the drug was sustained for 20 h, indicating the suitability of this system for colon-specific delivery of anti-cancer agents. Several drug chemical modification techniques have been employed to specifically deliver drugs to the colon, such as using prodrugs, which are pharmacologically inactive substances; however, they are activated when they reach the colon [16,17]. For instance, azo-based compounds composed of azo groups covalently attached to anti-inflammatory drugs used for irritable bowel diseases have been utilized for colon targeting of these drugs, where the resultant prodrugs become specifically active in the colon due to the reducing effect of azoreductase produced by gut microbiota cleaving the bond and release the drug to the site of interest [18].…”

Taste Masking of Promethazine Hydrochloride Using l-Arginine Polyamide-Based Nanocapsules

“…Further, other strategies, including the use of solid dispersion, the formation of salts or prodrugs, viscosity modifiers, or complexing, have been reported [ 6 , 8 , 9 ]. Nanotechnology has also been utilized for the entrapment of various drug types, such as the use of nanocrystals [ 10 , 11 ], solid lipid nanoparticles [ 12 ], nano-frameworks [ 13 ], PLGA nanoparticles [ 14 ], silica nanoparticles [ 15 ], chitosan nanoparticles [ 16 ], and liposomes [ 17 ].…”