Facile fabrication of robust polydopamine microcapsules for insulin delivery

Li, Hong; Jia, Yi; Feng, Xiyun; Li, Junbai

doi:10.1016/j.jcis.2016.10.012

Cited by 82 publications

(54 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since it has been found that PD supports cell growth [5], it might be expected that the proteins would experience more adhesion though the opposite appears to be true even when the unadjusted values are considered (Supplementary Information 2) except for mucin. The low adhesion observed with the PD-functionalised probes appears contradictory to the ease that PD can functionalise surfaces, as enabled by the displayed catechol, imine and amine groups [32]. The apparent low adhesion to protein films suggests that it may be ideal as a biomaterial or biomaterial coating by minimising interactions with proteins.…”

Section: Adhesionmentioning

confidence: 89%

See 1 more Smart Citation

Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation

2017

View full text Add to dashboard Cite

Polydopamine has been found to be a biocompatible polymer capable of supporting cell growth and attachment, and to have antibacterial and antifouling properties. Together with its ease of manufacture and application, it ought to make an ideal biomaterial and function well as a coating for implants. In this paper, atomic force microscope was used to measure the adhesive forces between polymer-, protein-or polydopamine-coated surfaces and a silicon nitride or polydopamine-functionalised probes. Surfaces were further characterised by contact angle goniometry, and solutions by circular dichroism. Polydopamine was further characterised with infrared spectroscopy and Raman spectroscopy. It was found that polydopamine functionalisation of the atomic force microscope probe significantly reduced adhesion to all tested surfaces. For example, adhesion to mica fell from 0.27 ± 0.7 to 0.05 ± 0.01 nN nm -1 . The results suggest that polydopamine coatings are suitable to be used for a variety of biomedical applications.

show abstract

Section: Adhesionmentioning

confidence: 89%

“…This agrees with Dague et al [31], who observed that Lactococcus lactis adhesion decreased after mucin adsorption. PD has been considered for use in oral formulations which benefit from the effect of pH on its release of encapsulated drugs [32], so it is of interest to investigate its interactions with mucin.…”

Section: Introductionmentioning

confidence: 99%

Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation

2017

View full text Add to dashboard Cite

show abstract

“…However, many capsules will buckle, collapse or even break when being subjected to drying, high vacuum as in the case of electronic microscope or experiencing external forces such as exerted by the cantilever of AFM. 4,6,7,9,10,[22][23][24][25] Furthermore, polymeric capsules oen need to be processed into other materials in the dried state and under high temperature and pressure. 15,26,27 Keeping the intactness of their precious capsule-like shape is demanding during such stringent processes since the loss of the shape unavoidably devalues the advantages brought by the hollow cavity, and high specic surface area.…”

Section: 17mentioning

confidence: 99%

“…5,6,[8][9][10][11][12] It is noted that most of PDA capsules prepared so far have a spherical shape, [4][5][6][7]11 while non-spherical ones may have additional advantages in cargo loading, cell uptake and enhanced packing efficiency in energetic materials. [13][14][15] However, preparation of non-spherical polymeric capsules is generally challenging.…”

Section: Introductionmentioning

confidence: 99%

“…Even so, PDA capsules are oen in the bulked or collapsed state aer airdrying, indicating a moderate mechanical strength. 4,6,7,9,10,12,22,37,38 Especially, although PDA have emerged as a very attractive precursor for nitrogen-doped carbon materials, preparation of hollow carbon particles or carbon capsules by carbonization of PDA involves multiple steps including PDA coating of hard templates, carbonization and template removing. 30,31,33,34 Carbonization of PDA coated templates might lead to the contamination of the carbon materials by the underlying templating materials, which can be avoid by direct carbonization of pure PDA capsules into carbon capsules.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Anisotropic polydopamine capsules with an ellipsoidal shape that can tolerate harsh conditions: efficient adsorbents for organic dyes and precursors for ellipsoidal hollow carbon particles

Zhang

et al. 2017

RSC Adv.

View full text Add to dashboard Cite

Polymeric capsules often buckle, collapse or even break when being processed in the dried state into other materials under high temperature and pressure due to moderate mechanical rigidity. In the case of nonspherical capsules, to keep their precious anisotropic morphology intact under harsh conditions is even more challenging since the whole surface of such kinds of capsules does not experience the same stress or strain due to the different surface curvatures. In the current work, we reported a strategy to prepare polydopamine (PDA) capsules with an ellipsoidal shape and enhanced mechanical rigidity using polystyrene ellipsoids as the sacrificial anisotropic templates. Bio-inspired oxidation induced selfpolymerization of dopamine can form conformal PDA coatings on polystyrene ellipsoids of various aspect ratios and sizes. Several strategies have been exploited to increase the thickness of the PDA shell, among which, iterating PDA coating produces ellipsoidal PDA capsules with a thick and robust shell.These ellipsoidal PDA capsules can survive carbonization at temperatures as high as 800 C and were directly turned into N-doped carbon capsules with a well-defined ellipsoidal shape, excluding the necessity of removing the sacrificial templates after carbonation. Furthermore, the rigid PDA ellipsoidal capsules are efficient adsorbents for organic dyes in contaminated water and have impressive adsorption efficiencies as high as 200 mg g À1.

show abstract

Photothermal Propelling and Pyroelectric Potential‐Promoted Cell Internalization of Janus Nanoparticles and Pyroelectrodynamic Tumor Therapy

Wei

Liu

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Cancer phototherapy experiences limitations in tissue diffusion and cell internalization of phototherapeutic agents and dose‐dependent side effects. Herein, Janus pyroelectric nanoparticles (NPs) are designed to generate self‐powered motion and built‐in electric fields to overcome the delivery barriers. Polydopamine (PDA) layers are partially coated on tetragonal BaTiO3 (tBT) NPs to prepare Janus tBT@PDA, and Au NPs are deposited on the PDA caps to obtain Janus tBT@PDA‐Au NPs. Near‐infrared (NIR) illumination of tBT@PDA‐Au builds in situ pyroelectric potentials on NPs, which selectively affect the membrane potential of tumor cells rather than normal cells to enhance tumor cell internalization and produce reactive oxygen species (ROS) for pyroelectric dynamic therapy (PEDT). The asymmetric photothermal effect of the Janus NPs creates thermophoretic force to propel NP motion, which enhances tumor diffusion and cellular uptake of NPs and boosts cytotoxicity and intracellular ROS levels. The inoculation of Au NPs increases the photothermal effect, exhibits larger motion velocities, produces higher pyroelectric potentials, and elevates cellular uptake rates, resulting in significant induction of tumor cell apoptosis, suppression of tumor growth, and extension of animal survival. Thus, the concise design of tBT@PDA‐Au/NIR treatment has achieved thermophoretic motion‐promoted tissue diffusion, built‐in electric field‐enhanced cell internalization, and photothermal/PEDT‐synergized antitumor efficacy.

show abstract

Facile fabrication of robust polydopamine microcapsules for insulin delivery

Cited by 82 publications

References 54 publications

Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation

Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation

Anisotropic polydopamine capsules with an ellipsoidal shape that can tolerate harsh conditions: efficient adsorbents for organic dyes and precursors for ellipsoidal hollow carbon particles

Photothermal Propelling and Pyroelectric Potential‐Promoted Cell Internalization of Janus Nanoparticles and Pyroelectrodynamic Tumor Therapy

Contact Info

Product

Resources

About