Facile fabrication of siloxane @ poly (methylacrylic acid) core-shell microparticles with different functional groups

Zhao, Zheng‐Bai; Tai, Li; Jiang, Yong

doi:10.1007/s11051-017-3777-y

Cited by 9 publications

(1 citation statement)

References 25 publications

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“…In addition, the different triggers of internal and external factors, such as length and ratio of the hydrophobic fraction, pH, solvent composition, and temperature, can change their morphology [12]. In addition, the advantage of the poly (glycidyl methacrylate) (PGMA) is being hydrophilic, as epoxy groups can be easily modified to carry a variety of reactive functional groups like NH 2 , COOH, and SH, which can be conjugated with biomolecules (antibodies, peptides, and drugs) [13], and stability (no aggregation) in various biological media. erefore, the PGMA polymer microsphere embeds the MNPs showing great potential in nanomedicine, biotechnology, and molecular biology [14].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Magnetic Properties of Magnetic Poly (glycidyl methacrylate) Microspheres: Experimental and Theoretical

Nguyen

2021

Advances in Materials Science and Engineering

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Biocompatible magnetic poly (glycidyl methacrylate) microsphere is a novel nanocomposite with a myriad of promising bioapplications. Investigation of their characteristics by experimental analysis methods has also been carried out in the past. However, a survey of the magnetic anisotropy constant has not been mentioned and the influence of the poly (glycidyl methacrylate) polymer matrix on the Fe3O4 magnetite nanoparticles embedded inside has also not been discussed. Moreover, the accurate characterization of the magnetite nanoparticle size distribution remains challenging. In this paper, we present an effective approach was used to solve these problems. First of all, we combine both experiment and theory to estimate the effective magnetic anisotropy constant. Besides that, we implement an accurate method to determine magnetite nanoparticle size distribution in the magnetic poly (glycidyl methacrylate) microspheres composite nanomaterial.

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Section: Introductionmentioning

confidence: 99%

Investigation of Magnetic Properties of Magnetic Poly (glycidyl methacrylate) Microspheres: Experimental and Theoretical

Nguyen

2021

Advances in Materials Science and Engineering

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The purification and identification of human blood serum proteins with affinity to the antitumor active RL2 lactaptin using magnetic microparticles

Manko

Starykovych

Bobak

et al. 2019

Biomedical Chromatography

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The cytopoxic effect of RL2 lactaptin (the recombinant analog of proteolytic fragment of human kappa‐casein) toward tumor cells in vitro and in vivo presents it as a novel promising antitumor drug. The binding of any drug with serum proteins can affect their activity, distribution, rate of excretion and toxicity in the human body. Here, we studied the ability of RL2 to bind to various blood serum proteins. Using magnetic microparticles bearing by RL2 as an affinity matrix, in combination with mass spectrometry and western blot analysis, we found a number of blood serum proteins possessing affinity for RL2. Among them IgA, IgM and IgG subclasses of immunoglobulins, apolipoprotein A1 and various cortactin isoforms were identified. This data suggests that in the bloodstream RL2 lactaptin takes part in complicate protein–protein interactions, which can affect its activity.

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Monodisperse magnetic poly(glycidyl methacrylate) microspheres for isolation of autoantibodies with affinity for the 46 kDa form of unconventional Myo1C present in autoimmune patients

et al. 2018

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Monodisperse nonmagnetic macroporous poly(glycidyl methacrylate) (PGMA) microspheres were synthesized by multistep swelling polymerization of glycidyl methacrylate, ethylene dimethacrylate and 2-[(methoxycarbonyl)methoxy]ethyl methacrylate (MCMEMA). This was followed (a) by ammonolysis to modify the microspheres with amino groups, and (b) by incorporation of iron oxide (γ-FeO) into the pores to render the particles magnetic. The resulting porous and magnetic microspheres were characterized by scanning and transmission electron microscopy (SEM and TEM), atomic absorption and Fourier transform infrared spectroscopy (AAS and FTIR), elemental analysis, vibrating magnetometry, mercury porosimetry and Brunauer-Emmett-Teller adsorption/desorption isotherms. The microspheres are meso- and macroporous, typically 5 μm in diameter, contain 0.9 mM · g of amino groups and 14 wt.% of iron according to elemental analysis and AAS, respectively. The particles were conjugated to p46/Myo1C protein, a potential biomarker of autoimmune diseases, to isolate specific autoantibodies in the blood of patients suffering from multiple sclerosis (MS). The p46/Myo1C loaded microspheres are shown to enable the preconcentration of minute quantities of specific immunoglobulins prior to their quantification via SDS-PAGE. The immunoglobulin M (IgM) with affinity to Myo1C was detected in MS patients. Graphical abstract Monodisperse magnetic poly(glycidyl methacrylate) microspheres were synthesized, conjugated with 46 kDa form of unconventional Myo1C protein (p46/Myo1C) via carbodiimide (DIC) chemistry, and specific autoantibodies isolated from blood of multiple sclerosis (MS) patients; immunoglobulin M (IgM) level increased in MS patients.

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Facile fabrication of siloxane @ poly (methylacrylic acid) core-shell microparticles with different functional groups

Cited by 9 publications

References 25 publications

Investigation of Magnetic Properties of Magnetic Poly (glycidyl methacrylate) Microspheres: Experimental and Theoretical

Investigation of Magnetic Properties of Magnetic Poly (glycidyl methacrylate) Microspheres: Experimental and Theoretical

The purification and identification of human blood serum proteins with affinity to the antitumor active RL2 lactaptin using magnetic microparticles

Monodisperse magnetic poly(glycidyl methacrylate) microspheres for isolation of autoantibodies with affinity for the 46 kDa form of unconventional Myo1C present in autoimmune patients

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