Facile fabrication of two-dimensional iodine nanosheets for antibacterial therapy

Ye, Yingmin; Wang, Yanmin; Zhang, Kai; Guo, Wei; Kong, Tianyu; Ding, Xiaokang; Zhao, Nana; Xu, Fu‐Jian

doi:10.1039/d2bm01763f

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…Ultrathin 2D nano-PSs are characteristic with large surface-to-volume ratio which can facilitate the energy transfer from excited photosensitizers to adjacent oxygen molecules as well as the diffusion of produced singlet oxygen ( 1 O 2 ), thereby boosting the photodynamic efficiency and outcomes. , Moreover, the ultrathin 2D nanosheets discussed above were facilely self-assembled from cationic porphyrins in pure water, which avoids the use of organic solvents or metal ions. Therefore, they are expected to possess good biocompatibility and potential for biological applications.…”

Section: Resultsmentioning

confidence: 99%

Exploring Linker-Group-Guided Self-Assembly of Ultrathin 2D Supramolecular Nanosheets in Water for Synergistic Cancer Phototherapy

Guo,

Li,

Huang

et al. 2023

ACS Appl. Mater. Interfaces

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Water is ubiquitous in natural systems where it builds an essential environment supporting biological supramolecular polymers to function, transport, and exchange. However, this extreme polar environment becomes a hindrance for the superhydrophobic functional π-conjugated molecules, causing significant negative impacts on regulating their aggregation pathways, structures, and properties of the subsequently assembled nanomaterials. It especially makes the self-assembly of ultrathin twodimensional (2D) functional nanomaterials by π-conjugated molecules a grand challenge in water, although ultrathin 2D functional nanomaterials have exhibited unique and superior properties. Herein, we demonstrate the organic solvent-free self-assembly of onemolecule-thick 2D nanosheets based on exploring how side chain modifications rule the aggregation behaviors of π-conjugated macrocycles in water. Through an in-depth understanding of the roles of linking groups for side chains on affecting the aggregation behaviors of porphyrins in water, the regulation of molecular arrangement in the aggregated state (H-or J-type aggregation) was attained. Moreover, by arranging ionic porphyrins into 2D single layers through J-aggregation, the ultrathin nanosheets (thickness ≈ 2 nm) with excellent solubility and stability were self-assembled in pure water, which demonstrated both outstanding 1 O 2 generation and photothermal capability. The ultrathin nanosheets were further investigated as metal-and carrier-free nanodrugs for synergetic phototherapies of cancers both in vitro and in vivo, which are highly desirable by combining the advantages and avoiding the disadvantages of the single use of PDT or PTT.

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Section: Resultsmentioning

confidence: 99%

Exploring Linker-Group-Guided Self-Assembly of Ultrathin 2D Supramolecular Nanosheets in Water for Synergistic Cancer Phototherapy

Guo,

Li,

Huang

et al. 2023

ACS Appl. Mater. Interfaces

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“…In current clinical practice, the appropriate utilization of antimicrobials remains a subject of significant debate and controversy . The use of antibiotics poses numerous risks, including toxic side effects, the emergence of drug-resistant pathogens, and secondary or cross-infections that can weaken immunity. − Additionally, metal ions’ high cytotoxicity and side effects hinder their further clinical application . Therefore, using safer and more effective drugs for wound treatment is crucial.…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Light-Responsive Nanofibrous Membranes for Treatment of Bacterial Wound Infections

Lin,

Sun,

Zhang

et al. 2023

ACS Appl. Nano Mater.

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Bacterial wound infections pose a significant challenge for both patients and healthcare providers. To effectively treat bacterial wound infections, it is critical to develop functional wound dressings that can eradicate bacteria and promote wound healing. Herein, we report a facile and eco-friendly route for preparing a near-infrared (NIR) light-responsive bifunctional botanicals nanofibrous membrane as a wound dressing for the synergistic treatment of bacterial wound infections. The as-prepared nanofibrous membrane consisted of poly(vinyl alcohol) as a support matrix, tannic acid−Fe(III) nanoparticles as NIR laser-activated photothermal nanoagents, and berberine hydrochloride as the active botanicals. The bifunctional nanofibrous membrane exhibited high porosity, hydrophilicity, breathability, and biocompatibility, rendering it an optimal wound dressing. More importantly, the bifunctional nanofibrous membrane exhibited a synergistic sterilization performance under NIR laser irradiation to produce sufficient hyperthermia and on-demand release of botanicals. In vivo experiments demonstrated that the nanofibrous membrane could effectively kill bacteria in the early stages of infected wounds, promote collagen deposition, and accelerate wound healing. In summary, our bifunctional nanofibrous membrane presents immense potential for clinical applications in preventing bacterial infections and promoting skin repair.

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“…In the current research field of nacre-inspired composites, the preparation process of the bricks determines their morphology and structure. , The micrometers/nanosheets include clay, layered double hydroxides (LDH), graphite, and other artificial layers, which are difficult to prepare as large and uniform due to chemical or mechanical delamination leading to layer fracture and incomplete delamination. ,− In addition, sheet-like alumina and calcium carbonate nanoparticles synthesized by “down-top” methods cannot achieve high aspect ratios. , Therefore, adjustable uniform nanosheets with large diameters (≥10 μm) and high aspect ratios are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Large-Diameter Silica Nanosheets for Self-Assembly into Composite Films

Yuan,

Hua,

Zhu

et al. 2023

ACS Appl. Nano Mater.

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The nacre-inspired “brick-and-mortar” structure is used to prepare materials with high strength, toughness, and barrier performance by setting geometric parameters, such as the diameter, thickness, and aspect ratio of the assembly blocks. However, there have been no reports of large-diameter “bricks”. Herein, we report the synthesis of silica nanosheets with ∼20 μm diameter and adjustable aspect ratios using anionic and cationic surfactant micelle templates, and the self-assembly of the nanosheets was assisted by a heat pressing process to form ethyl cellulose (EC) composite films. Such a large-block brick-and-mortar structure has significantly improved the various properties of the composite films, including increasing the strength and Young’s modulus of the EC films by 160 and 429%, respectively, maintaining 97% transparency (with a content of 50 wt % silica nanosheets), and increasing gas barrier performance by 120 times. We establish comprehensive relationships among the high performance of nacre-inspired films and the diameter and aspect ratio of the nanosheets, which will pave the way for the practical application of flexible optical barrier films.

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Facile fabrication of two-dimensional iodine nanosheets for antibacterial therapy

Abstract: Herein, we report a facile approach for the preparation of two-dimensional iodine nanosheets (2D iodine NSs) with good stability and high biocompatibility through an aqueous solvent-assisted ultrasonic route. Due to...

Cited by 4 publications

References 30 publications

Exploring Linker-Group-Guided Self-Assembly of Ultrathin 2D Supramolecular Nanosheets in Water for Synergistic Cancer Phototherapy

Exploring Linker-Group-Guided Self-Assembly of Ultrathin 2D Supramolecular Nanosheets in Water for Synergistic Cancer Phototherapy

Near-Infrared Light-Responsive Nanofibrous Membranes for Treatment of Bacterial Wound Infections

Large-Diameter Silica Nanosheets for Self-Assembly into Composite Films

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