Facile formation of injectable quaternized chitosan/tannic acid hydrogels with antibacterial and ROS scavenging capabilities for diabetic wound healing

Pan, Wenhao; Qi, Xiao-Liang; Xiang, Yajing; You, Shengye; Cai, Erya; Gao, Teng; Tong, Xianqin; Hu, Rongdang; Shen, Jianliang; Deng, Hui

doi:10.1016/j.ijbiomac.2021.12.007

Cited by 187 publications

(43 citation statements)

References 49 publications

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“…Tannic acid is another natural polyphenol with antioxidant, antimicrobial, and antiinflammatory properties, but is also able to influence the structure and conformation of fibrinogen to form fibrin. In comparison with tannic acid, which could potentially be dangerous for renal fibrosis development and the poor evolution of kidney diseases [140][141][142], in elderflower extract, antifibrotic and nephroprotective effects against gentamicin-induced nephrotoxicity have been proven [10].…”

Section: Role Of Caffeic Acid and Ferulic Acidmentioning

confidence: 99%

A Flavonoid-Rich Extract of Sambucus nigra L. Reduced Lipid Peroxidation in a Rat Experimental Model of Gentamicin Nephrotoxicity

et al. 2022

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The use of gentamicin (GM) is limited due to its nephrotoxicity mediated by oxidative stress. This study aimed to evaluate the capacity of a flavonoid-rich extract of Sambucus nigra L. elderflower (SN) to inhibit lipoperoxidation in GM-induced nephrotoxicity. The HPLC analysis of the SN extract recorded high contents of rutin (463.2 ± 0.0 mg mL−1), epicatechin (9.0 ± 1.1 µg mL−1), and ferulic (1.5 ± 0.3 µg mL−1) and caffeic acid (3.6 ± 0.1 µg mL−1). Thirty-two Wistar male rats were randomized into four groups: a control group (C) (no treatment), GM group (100 mg kg−1 bw day−1 GM), GM+SN group (100 mg kg−1 bw day−1 GM and 1 mL SN extract day−1), and SN group (1 mL SN extract day−1). Lipid peroxidation, evaluated by malondialdehyde (MDA), and antioxidant enzymes activity—superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX)—were recorded in renal tissue after ten days of experimental treatment. The MDA level was significantly higher in the GM group compared to the control group (p < 0.0001), and was significantly reduced by SN in the GM+SN group compared to the GM group (p = 0.021). SN extract failed to improve SOD, CAT, and GPX activity in the GM+SN group compared to the GM group (p > 0.05), and its action was most probably due to the ability of flavonoids (rutin, epicatechin) and ferulic and caffeic acids to inhibit synthesis and neutralize reactive species, to reduce the redox-active iron pool, and to inhibit lipid peroxidation. In this study, we propose an innovative method for counteracting GM nephrotoxicity with a high efficiency and low cost, but with the disadvantage of the multifactorial environmental variability of the content of SN extracts.

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Section: Role Of Caffeic Acid and Ferulic Acidmentioning

confidence: 99%

A Flavonoid-Rich Extract of Sambucus nigra L. Reduced Lipid Peroxidation in a Rat Experimental Model of Gentamicin Nephrotoxicity

et al. 2022

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“…7D, E, and S5A ). On day 7, the wound areas of the hydrogel Ⅲ–IV group were significantly smaller than that of the gauze control group and the HeraDerm group, and the hydrogel Ⅳ-treated wounds were also smaller at day 7 than those in some previous studies [ [51] , [52] , [53] , [54] ]. On day 10, the wound contraction of the hydrogel Ⅱ group was about 4.84 ± 2.19% higher than that of the HeraDerm group, while the wound healing rate of the hydrogel IV group surpassed approximately 20.1 ± 2.48% of that of the HeraDerm group, indicating that the release system of hydrogel Ⅳ could release insulin and celecoxib effective in wounds, and hydrogel Ⅱ containing CS and gelatin can also promote wound healing.…”

Section: Resultsmentioning

confidence: 54%

Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing

Zhou

Duan

Zhao

et al. 2022

Bioactive Materials

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“…PVA:TA cryogels possess a high blood clotting index value, and the coagulant effect of cryogels containing TA is lower than that of PVA. It is known that TA promotes the coagulation effect [ 58 , 59 ]. As illuminated here, TA that has many hydroxyl groups can readily interact with PVA via hydrogen bonding, affording a lower blood clotting index capability than PVA cryogels and thus promoting the blood contacting application of the prepared materials.…”

Section: Discussionmentioning

confidence: 99%

Poly(vinyl alcohol)-tannic Acid Cryogel Matrix as Antioxidant and Antibacterial Material

et al. 2021

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The biocompatible, viscoelastic properties of poly(vinyl alcohol) (PVA) in combination with the antimicrobial and antioxidant natural polyphenolic, tannic acid (TA), and the natural flavonoid and antioxidant curcumin (Cur), were used in the preparation of PVA:TA and PVA:TA:Cur cryogel composites using cryotropic gelation to combine the individually beneficial properties. The effect of TA content on the antioxidant and antimicrobial activities of PVA:TA cryogel composites and the antioxidant activities of PVA:TA:Cur cryogel composites was determined using Trolox equivalent antioxidant capacity (TEAC) and total phenol content (TPC) assays, and were compared. The PVA:TA:Cur cryogel composite showed the highest antioxidant activity, with a TEAC value of 2.10 ± 0.24 and a TPC value of 293 ± 12.00. The antibacterial capacity of the PVA:TA and PVA:TA:Cur 1:1:0.1 cryogel composites was examined against two different species of bacteria, E. coli and S. aureus. It was found that the minimum inhibition concentration (MIC) value of the PVA:TA:Cur 1:1:0.1 cryogel composites varied between 5 and 10 mg/mL based on the type of microorganism, and the minimum bactericidal concentration (MBC) value was 20 mg/mL irrespective of the type of microorganism. Furthermore, the hemocompatibility of the PVA:TA cryogel composites was evaluated by examining their hemolytic and coagulation behaviors. PVA:TA 1:1 cryogels with a value of 95.7% revealed the highest blood clotting index value amongst all of the synthesized cryogels, signifying the potential for blood contacting applications. The release of TA and Cur from the cryogel composites was quantified at different pH conditions, i.e., 1.0, 7.4, and 9.0, and additionally in ethanol (EtOH) and an ethanol–water (EtOH:Wat) mixture. The solution released from the PVA:TA cryogels in PBS was tested for inhibition capability against α-glucosidase (E.C. 3.2.1.20). Concentration-dependent enzyme inhibition was observed, and 70 µL of 83 µg/mL PVA:TA (1:1) cryogel in PBS inhibited α-glucosidase enzyme solution of 0.03 unit/mL in 70 µL by 81.75 ± 0.96%.

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Facile formation of injectable quaternized chitosan/tannic acid hydrogels with antibacterial and ROS scavenging capabilities for diabetic wound healing

Cited by 187 publications

References 49 publications

A Flavonoid-Rich Extract of Sambucus nigra L. Reduced Lipid Peroxidation in a Rat Experimental Model of Gentamicin Nephrotoxicity

A Flavonoid-Rich Extract of Sambucus nigra L. Reduced Lipid Peroxidation in a Rat Experimental Model of Gentamicin Nephrotoxicity

Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing

Poly(vinyl alcohol)-tannic Acid Cryogel Matrix as Antioxidant and Antibacterial Material

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