Facile Grafting of Silver Nanoparticles into Copper and Guanosine 5′-Monophosphate Metal Organic Frameworks (AgNPs@Cu/GMP): Characterization and Antimicrobial Activity

Soomro, Najaf Ali; Amur, Safdar Ali; Wei, Yun; Shah, Aamir Hassan; Jiao, Mengzhao; Liang, Hao; Yuan, Qeping

doi:10.1007/s10876-020-01908-2

Cited by 3 publications

(4 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…48 Similarly, results presented by Soomro and coworkers revealed that copper( ii ) and guanosine 5′-monophosphate-based MOF (Cu/GMP) showed higher antimicrobial activity after impregnation with AgNPs (AgNPs@Cu/GMP). 49 The inhibition zones for Cu/GMP and AgNPs@Cu/GMP were determined at 12 and 17 mm against S. aureus and 9 and 10 mm against E. coli , respectively. The MIC values for AgNPs@Cu/GMP were 18.75 μg mL −1 against S. aureus and 25 μg mL −1 against E. coli .…”

Section: Resultsmentioning

confidence: 99%

A new MOF@bioactive glass composite reinforced with silver nanoparticles – a new approach to designing antibacterial biomaterials

Fandzloch,

Augustyniak,

Trzcińska-Wencel

et al. 2024

Dalton Trans.

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

A new MOF@bioactive glass composite reinforced with silver nanoparticles – a new approach to designing antibacterial biomaterials

Fandzloch,

Augustyniak,

Trzcińska-Wencel

et al. 2024

Dalton Trans.

View full text Add to dashboard Cite

show abstract

“…The developed zones that restrict growth around each well were gauged in mm, the length of the hole was measured (i.e., 6 mm), and the nal results are presented as the means ± SDs of triplicate samples. The minimum inhibitory concentration (MIC) of Glab@ZIF-8 nanoparticles was done as reported somewhere [40]. For this a 10 10 µL of fresh bacteria culture were added to 4 mL LB media in test tubes, thus, a different concentartions (µg/mL) of Glab@ZIF-8 were loaded.…”

Section: Antibacterial Activity Of Synthesized Materialsmentioning

confidence: 99%

Facile encapsulation of glabridin in Zeolitic Imidazolate Framework-8 (ZIF- 8): Characterization, antibacterial activity and in-vitro drug release

Amur,

Soomro,

Khuhro

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

In this research, a natural bioactive glabridin (Glab) flavonoid compound was encapsulated in zeolitic imidazolate framework-8 (ZIF-8) via one-pot technique at room temperature. Herein, ~98.7% of drug was encapsulated into ZIF-8 coreshell, which depicted 28.44% drug encapsulation productivity of ZIF-8. Fourier transform infrared (FTIR), UV‒Vis spectroscopy and X‑ray crystallography (XRD) confirmed the drug encapsulation. Next, the newly constructed nanomaterials were greatly studied with, dynamic light scattering (DLS), scanning electron microscope (SEM), energy-dispersive X-ray (EDX) analysis, transmission electron microscope (TEM) and thermo gravimetric analysis (TGA) technologies. SEM and TEM showed hexagonal morphology of Glab@ZIF-8 and an increased particle size to that of ZIF-8 i.e., 138.62±5.4 nm and 91.69±6.2 nm, respectively. TGA depicted 32.14% Glab@ZIF-8 material’s decomposition at 644 °C. The antibacterial efficacy of Glab@ZIF-8 was found superior against S. aureus than E. coli and Bacillus subtilis, resulting 26±0.01 mm, 23±0.02 mm and 11±0.01 mm inhibition zones and MIC values 31.2 µg, 62.5 µg and 125 µg, separately. Though, the Glab@ZIF-8 kept in an acidic medium (pH 5) for 72 h showed highest drug release 89.76% as compared to the pH 5.5 (81.23%) and pH 7.4 (24.78%). In conclusion, ZIF-8 remained a potential drug delivery system and Glab@ZIF-8 nanocomposite can be accredited for broader biomedical applications to cure infection diseases and malignant cells.

show abstract

“…These limitations can be removed by grafting the AgNPs into metal–organic frameworks. Soomro et al successfully loaded AgNPs into Cu/GMP (GMP = guanosine 50-monophosphate) frameworks at room temperature (encapsulation ratio 99.83% at neutral pH) . The AgNPs@Cu/GMP composite was tested to show improved antimicrobial properties against Gram-positive bacteria S.…”

Section: Mofs Vs Microorganismsmentioning

confidence: 99%

“…Soomro et al successfully loaded AgNPs into Cu/GMP (GMP = guanosine 50-monophosphate) frameworks at room temperature (encapsulation ratio 99.83% at neutral pH). 116 The AgNPs@Cu/ GMP composite was tested to show improved antimicrobial properties against Gram-positive bacteria S. aureus and Gramnegative bacteria E. coli (Figure 10). Moreover, the composite AgNPs@Cu/GMP was remarkably stable (∼6 times greater than pristine AgNPs) even after 15 days.…”

Section: ■ Mofs Vs Microorganismsmentioning

confidence: 99%

Smart Metal–Organic Frameworks for Biotechnological Applications: A Mini-Review

Chattopadhyay

Mandal

Maiti

2021

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

In this pandemic situation it is evident that viruses and bacteria, more specifically, multiple drug resistant (MDR) bacteria, endanger human civilization severely. It is high time to design smart weapons to combat these pathogens for the prevention and cure of allied ailments. Metal–organic frameworks (MOFs) are porous materials designed from metal ions or inorganic clusters and multidentate organic ligands. Due to some unique features like high porosity, tunable pore shape and size, numerous possible metal-ligand combinations, etc., MOFs are ideal candidates to design “smart biotechnological tools”. MOFs construct promising fluorescence based biosensing platforms for detection of viruses. MOFs also exhibit excellent antibacterial activity due to their ability for sustained release of active biocidal agents. There are several reviews that summarize the antibacterial applications of MOFs, but the biosensing platforms based on MOFs for detection of viruses have scarcely been summarized. This review carefully covers both the aspects including virus detection (nucleic acid recognition and immunological detection) with underlying mechanisms as well as antibacterial application of MOFs and doped MOFs or composites. This review will deliver valuable information and references for designing new, smarter antimicrobial agents based on MOFs.

show abstract

Facile Grafting of Silver Nanoparticles into Copper and Guanosine 5′-Monophosphate Metal Organic Frameworks (AgNPs@Cu/GMP): Characterization and Antimicrobial Activity

Cited by 3 publications

References 66 publications

A new MOF@bioactive glass composite reinforced with silver nanoparticles – a new approach to designing antibacterial biomaterials

A new MOF@bioactive glass composite reinforced with silver nanoparticles – a new approach to designing antibacterial biomaterials

Facile encapsulation of glabridin in Zeolitic Imidazolate Framework-8 (ZIF- 8): Characterization, antibacterial activity and in-vitro drug release

Smart Metal–Organic Frameworks for Biotechnological Applications: A Mini-Review

Contact Info

Product

Resources

About