Facile green synthesis and potent antimicrobial efficacy of β-aminoheteronapthol via tailored Betti’s protocol and their bis-aryl hydrazone click products

Abstract

A series of novel Mannich base and their hydrazone derivatives were synthesized by highly resourceful, chic, simple and green technique with exceptionally facile reaction conditions of one-pot, three component reaction with an array of biologically and pharmaceutically active novel heterocycles. The protocol offers a valuable alternative to known methods and will find applications in the field of green synthesis and antimicrobial study against pathogenic microbes, supporting the development of bioinformatical database of novel and derelict heterocycles. These data indicate their potential to become antifungal agents. The novel products were established by elemental, IR, mass spectroscopic and NMR analysis. The environmental advantages of the method include short reaction time, excellent yield, easy work-up, absence of extraction and chromatographic purification steps.

Synthesis and application of novel 1,2,3‐triazolylferrocene‐containing ionic liquid supported on Fe3O4 nanocatalyst in the synthesis of new pyran‐substituted Betti bases

“…One of the important multicomponent reactions is the Betti reaction which was introduced by Mario Betti . After the initial report of the synthesis of Betti bases, the study of these compounds has become an important area, because of their significant biological, synthetic and catalytic applications.…”